The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Cell contraction induces long-ranged stress stiffening in the extracellular matrix
Open accessAbstract
Significance: The behavior of cells is strongly affected by the mechanics of their surroundings. In tissues, cells interact with the extracellular matrix, a 3D network of biopolymers with a highly nonlinear elastic response. We introduce a method exploiting this matrix nonlinearity to infer mechanical stresses in 3D. Using this method, we demonstrate that cell contractility induces large stresses, which generate a massive stiffness gradient over an extended region in 3D matrices of collagen, fibrin, and Matrigel. Our work highlights the importance of nonlinear matrix mechanics at the microscopic scale and suggests a concrete mechanism through which cells can control their microenvironment and mechanically communicate with each other.
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Cites
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Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
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Tissue Cells Feel and Respond to the Stiffness of Their Substrate
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Discher, D. E., Mooney, D. J., & Zandstra, P. W. (2009) · Science · doi:10.1126/science.1171643 · Cited by 2,667
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Griffith, L. G., & Swartz, M. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1858 · Cited by 2,290
Collagen reorganization at the tumor-stromal interface facilitates local invasion
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Nonlinear elasticity in biological gels
Storm, C., Pastore, J. J., MacKintosh, F. C., Lubensky, T. C., & Janmey, P. A. (2005) · Nature · doi:10.1038/nature03521 · Cited by 1,703
Matrigel: Basement membrane matrix with biological activity
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Elastic Behavior of Cross-Linked and Bundled Actin Networks
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Cited by
Effects of extracellular matrix viscoelasticity on cellular behaviour
Chaudhuri, O., Cooper-White, J., Janmey, P. A., Mooney, D. J., & Shenoy, V. B. (2020) · Nature · doi:10.1038/s41586-020-2612-2 · Cited by 2,224
Nia, H. T., Munn, L. L., & Jain, R. K. (2020) · Science · doi:10.1126/science.aaz0868 · Cited by 855
From mechanical resilience to active material properties in biopolymer networks
Burla, F., Mulla, Y., Vos, B. E., Aufderhorst-Roberts, A., & Koenderink, G. H. (2019) · Nature Reviews Physics · doi:10.1038/s42254-019-0036-4 · Cited by 224
Complex mechanics of the heterogeneous extracellular matrix in cancer
Malandrino, A., Mak, M., Kamm, R. D., & Moeendarbary, E. (2018) · Extreme Mechanics Letters · doi:10.1016/j.eml.2018.02.003 · Cited by 192
Self-citationThe extracellular matrix viscoelasticity as a regulator of cell and tissue dynamics
Elosegui-Artola, A. (2021) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2021.04.002 · Cited by 170
Metadata
- Authors
- Han, Y. L., Ronceray, P., Xu, G., Malandrino, A., Kamm, R. D., Lenz, M., Broedersz, C. P., & Guo, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-04-04
- Volume
- 115
- Issue
- 16
- Pages
- 4075-4080
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2750853956
- Cited by
- 300
- References
- 54
- FWCI
- 15.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Han, Y. L., Ronceray, P., Xu, G., Malandrino, A., Kamm, R. D., Lenz, M., Broedersz, C. P., & Guo, M. (2018). Cell contraction induces long-ranged stress stiffening in the extracellular matrix. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1722619115
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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