The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Biological sex affects vaccine efficacy and protection against influenza in mice
Open accessAbstract
Significance: Biological sex is typically not considered in the evaluation of vaccine responses and protection against infection. We show that female mice mount greater humoral and cell-mediated immune responses to influenza infection and vaccination than males. Females can rely solely on antibody for protection following vaccination, which is associated with greater expression of toll-like receptor 7 ( Tlr7 ) caused by epigenetic mechanisms in B cells from females. Deletion of Tlr7 reduces sex differences in vaccine-induced antibody responses and protection. The increased expression of Tlr7 in B cells contributes to greater antibody production in females than males, which has a functional advantage for vaccine efficacy.
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Cites
Sex differences in immune responses
Klein, S. L., & Flanagan, K. L. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.90 · Cited by 6,370
Self-citationIgG placental transfer in healthy and pathological pregnancies
Palmeira, P., Quinello, C., Silveira-Lessa, A. L., Zago, C. A., & Carneiro-Sampaio, M. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/985646 · Cited by 1,037
Rubtsov, A. V., Rubtsova, K., Fischer, A., Meehan, R. T., Gillis, J. Z., Kappler, J. W., & Marrack, P. (2011) · Blood · doi:10.1182/blood-2011-01-331462 · Cited by 808
Control of B-cell responses by Toll-like receptors
Pasare, C., & Medzhitov, R. (2005) · Nature · doi:10.1038/nature04267 · Cited by 752
Furman, D., Hejblum, B. P., Simon, N., Jojic, V., Dekker, C. L., Thiébaut, R., Tibshirani, R. J., & Davis, M. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1321060111 · Cited by 673
TLR7 escapes X chromosome inactivation in immune cells
Souyris, M., Cenac, C., Azar, P., Daviaud, D., Canivet, A., Grunenwald, S., Pienkowski, C., Chaumeil, J., Mejía, J. E., & Guéry, J.-C. (2018) · Science Immunology · doi:10.1126/sciimmunol.aap8855 · Cited by 641
Wu, T., Hu, Y., Lee, Y.-T., Bouchard, K. R., Benechet, A., Khanna, K., & Cauley, L. S. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0313180 · Cited by 530
Sex and Gender Differences in the Outcomes of Vaccination over the Life Course
Flanagan, K. L., Fink, A. L., Plebanski, M., & Klein, S. L. (2017) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100616-060718 · Cited by 508
Self-citationIgG2a restriction of murine antibodies elicited by viral infections.
Coutelier, J. P., van der Logt, J. T., Heessen, F. W., Warnier, G., & Van Snick, J. (1987) · The Journal of experimental medicine · doi:10.1084/jem.165.1.64 · Cited by 428
Grindstaff, J. L., Brodie, E. D., & Ketterson, E. D. (2003) · Proceedings of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rspb.2003.2485 · Cited by 425
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Sex and gender: modifiers of health, disease, and medicine
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Self-citationSex differences in immune responses that underlie COVID-19 disease outcomes
Takahashi, T., Ellingson, M. K., Wong, P., Israelow, B., Lucas, C., Klein, J., Silva, J., Mao, T., Oh, J. E., Tokuyama, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2700-3 · Cited by 1,459
Immunoinformatics and Vaccine Development: An Overview
Oli, A. N., Obialor, W. O., Ifeanyichukwu, M. O., Odimegwu, D. C., Okoyeh, J. N., Emechebe, G. O., Adejumo, S. A., & Ibeanu, G. C. (2020) · ImmunoTargets and Therapy · doi:10.2147/itt.s241064 · Cited by 281
The non-specific and sex-differential effects of vaccines
Aaby, P., Benn, C. S., Flanagan, K. L., Klein, S. L., Kollmann, T. R., Lynn, D. J., & Shann, F. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-020-0338-x · Cited by 142
Self-citationLau, E. S., McNeill, J. N., Paniagua, S. M., Liu, E. E., Wang, J. K., Bassett, I. V., Selvaggi, C. A., Lubitz, S. A., Foulkes, A. S., & Ho, J. E. (2021) · PLOS ONE · doi:10.1371/journal.pone.0250774 · Cited by 65
Metadata
- Authors
- Fink, A. L., Engle, K., Ursin, R. L., Tang, W.-Y., & Klein, S. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-11-19
- Volume
- 115
- Issue
- 49
- Pages
- 12477-12482
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2901467783
- Cited by
- 253
- References
- 32
- FWCI
- 14.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fink, A. L., Engle, K., Ursin, R. L., Tang, W.-Y., & Klein, S. L. (2018). Biological sex affects vaccine efficacy and protection against influenza in mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1805268115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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