Sex and gender: modifiers of health, disease, and medicine
Open accessAbstract
Clinicians can encounter sex and gender disparities in diagnostic and therapeutic responses. These disparities are noted in epidemiology, pathophysiology, clinical manifestations, disease progression, and response to treatment. This Review discusses the fundamental influences of sex and gender as modifiers of the major causes of death and morbidity. We articulate how the genetic, epigenetic, and hormonal influences of biological sex influence physiology and disease, and how the social constructs of gender affect the behaviour of the community, clinicians, and patients in the health-care system and interact with pathobiology. We aim to guide clinicians and researchers to consider sex and gender in their approach to diagnosis, prevention, and treatment of diseases as a necessary and fundamental step towards precision medicine, which will benefit men's and women's health.
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Achievement of MASH resolution requires moderate body weight reduction for men, whereas much greater weight loss is required for resolution in pre-menopausal women.
“Remarkably, achievement of MASH resolution requires moderate body weight reduction for men, whereas much greater weight loss is required for resolution in pre-menopausal women [30].”
From Obesity and MASLD: Is weight loss the (only) key to treat metabolic liver disease? (2024) · cites this paper as [30]
The Chronic liver disease section says that steatohepatitis resolution requires moderate bodyweight reduction in men and much greater weight loss in women. It does not limit that finding to premenopausal women; the table in Conclusions and perspectives discusses menopausal status for disease risk, but not for the weight-loss requirement. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSex and gender are important determinants of health outcomes.
“Sex and gender are important determinants of health outcomes.58”
From Global health 2050: the path to halving premature death by mid-century (2024) · cites this paper as [58]
Sex-related and gender-related attributes separately and jointly moderate many human health outcomes.
“Sex-related and gender-related attributes separately and jointly act as moderators of many human health outcomes7,52.”
From Sex and gender in neurodevelopmental conditions (2023) · cites this paper as [7]
It is not known whether GLP-1 RAs are equally beneficial in women.
“It is not known whether these newer diabetes medications are equally beneficial in women [12,13].”
From Real-world sex differences in type 2 diabetes patients treated with GLP-1 receptor agonists (2024) · cites this paper as [12]
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Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Clinical characteristics of coronavirus disease 2019 in China
Guan, W.-J., Ni, Z.-Y., Hu, Y., Liang, W.-H., Ou, C.-Q., He, J.-X., Liu, L., Shan, H., Lei, C.-L., Hui, D. S. C., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2002032 · Cited by 30,246 · see citing works
Siegel, R. L., Miller, K. D., & Jemal, A. (2017) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21387 · Cited by 14,712 · see citing works
Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17018-9 · Cited by 12,026 · see citing works
Younossi, Z. M., Koenig, A. B., Abdelatif, D., Fazel, Y., Henry, L., & Wymer, M. (2016) · Hepatology · doi:10.1002/hep.28431 · Cited by 10,781 · see citing works
Richardson, S., Hirsch, J. S., Narasimhan, M., Crawford, J. M., McGinn, T., Davidson, K. W., and the Northwell COVID-19 Research Consortium, Barnaby, D. P., Becker, L. B., Chelico, J. D., et al. (2020) · JAMA · doi:10.1001/jama.2020.6775 · Cited by 9,254 · see citing works
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036 · see citing works
Roth, G. A., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32203-7 · Cited by 8,600 · see citing works
Self-citationWang, H., Naghavi, M., Allen, C., Barber, R. M., Bhutta, Z. A., Carter, A., Casey, D. C., Charlson, F. J., Chen, A. Z., Coates, M. M., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31012-1 · Cited by 6,596 · see citing works
Self-citationGrasselli, G., Zangrillo, A., Zanella, A., Antonelli, M., Cabrini, L., Castelli, A., Cereda, D., Coluccello, A., Foti, G., Fumagalli, R., et al. (2020) · JAMA · doi:10.1001/jama.2020.5394 · Cited by 5,469 · see citing works
2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069 · see citing works
Fiore, A. E., Shay, D. K., Broder, K., Iskander, J. K., Uyeki, T. M., Mootrey, G., Bresee, J. S., & Cox, N. S. (2001) · PsycEXTRA Dataset · doi:10.1037/e548312006-001 · Cited by 5,006 · see citing works
2019 Alzheimer’s disease facts and figures.
Alzheimer's Association (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.01.010 · Cited by 2,461 · see citing works
O'Donnell, M. J., Chin, S. L., Rangarajan, S., Xavier, D., Liu, L., Zhang, H., Rao-Melacini, P., Zhang, X., Pais, P., Agapay, S., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)30506-2 · Cited by 2,296 · see citing works
Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus
Kautzky-Willer, A., Harreiter, J., & Pacini, G. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1137 · Cited by 2,043 · see citing works
Policy: NIH to balance sex in cell and animal studies
Clayton, J. A., & Collins, F. S. (2014) · Nature · doi:10.1038/509282a · Cited by 1,816 · see citing works
Krammer, F., Smith, G. J. D., Fouchier, R. A. M., Peiris, M. J. S., Kedzierska, K., Doherty, P. C., Palese, P., Shaw, M. L., Treanor, J. J., Webster, R. G., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0002-y · Cited by 1,591 · see citing works
Depression Is the Leading Cause of Disability Around the World
Friedrich, M. J. (2017) · JAMA · doi:10.1001/jama.2017.3826 · Cited by 1,459 · see citing works
Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes
Reeves, M. J., Bushnell, C. D., Howard, G., Gargano, J. W., Duncan, P. W., Lynch, G., Khatiwoda, A., & Lisabeth, L. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70193-5 · Cited by 1,362 · see citing works
H1N1 2009 influenza virus infection during pregnancy in the USA
Jamieson, D. J., Honein, M. A., Rasmussen, S. A., Williams, J. L., Swerdlow, D. L., Biggerstaff, M., Lindstrom, S., Louie, J. K., Christ, C. M., Bohm, S. R., et al. (2009) · The Lancet · doi:10.1016/s0140-6736(09)61304-0 · Cited by 1,340 · see citing works
Sex differences in autoimmune disease
Whitacre, C. C. (2001) · Nature Immunology · doi:10.1038/ni0901-777 · Cited by 1,271 · see citing works
Sex differences in autism spectrum disorders
Werling, D. M., & Geschwind, D. H. (2013) · Current Opinion in Neurology · doi:10.1097/wco.0b013e32835ee548 · Cited by 1,245 · see citing works
Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association
Mehta, L. S., Beckie, T. M., DeVon, H. A., Grines, C. L., Krumholz, H. M., Johnson, M. N., Lindley, K. J., Vaccarino, V., Wang, T. Y., Watson, K. E., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000351 · Cited by 1,244 · see citing works
Emotion regulation and psychopathology: the role of gender.
Nolen-Hoeksema, S. (2012) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032511-143109 · Cited by 1,225 · see citing works
Lonardo, A., Nascimbeni, F., Ballestri, S., Fairweather, D., Win, S., Than, T. A., Abdelmalek, M. F., & Suzuki, A. (2019) · Hepatology · doi:10.1002/hep.30626 · Cited by 1,057 · see citing works
Self-citationSex/Gender Differences in Cardiovascular Disease Prevention: What a Difference a Decade Makes
Mosca, L., Barrett-Connor, E., & Kass Wenger, N. (2011) · Circulation · doi:10.1161/circulationaha.110.968792 · Cited by 1,045 · see citing works
Sex differences in Alzheimer disease — the gateway to precision medicine
for the Women’s Brain Project and the Alzheimer Precision Medicine Initiative, Ferretti, M. T., Iulita, M. F., Cavedo, E., Chiesa, P. A., Schumacher Dimech, A., Santuccione Chadha, A., Baracchi, F., Girouard, H., Misoch, S., et al. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0032-9 · Cited by 1,009 · see citing works
Cancer immunotherapy efficacy and patients' sex: a systematic review and meta-analysis
Conforti, F., Pala, L., Bagnardi, V., De Pas, T., Martinetti, M., Viale, G., Gelber, R. D., & Goldhirsch, A. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30261-4 · Cited by 973 · see citing works
Bushnell, C., McCullough, L. D., Awad, I. A., Chireau, M. V., Fedder, W. N., Furie, K. L., Howard, V. J., Lichtman, J. H., Lisabeth, L. D., Piña, I. L., et al. (2014) · Stroke · doi:10.1161/01.str.0000442009.06663.48 · Cited by 941 · see citing works
Self-citationSex and gender disparities in the epidemiology and outcomes of chronic kidney disease
Carrero, J. J., Hecking, M., Chesnaye, N. C., & Jager, K. J. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.181 · Cited by 931 · see citing works
Self-citationSex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection
Channappanavar, R., Fett, C., Mack, M., Eyck, P. T., Meyerholz, D. K., & Perlman, S. M. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601896 · Cited by 896 · see citing works
Sex modifies the <i>APOE</i> ‐related risk of developing Alzheimer disease
Altmann, A., Tian, L., Henderson, V. W., Greicius, M. D., & Alzheimer's Disease Neuroimaging Initiative Investigators (2014) · Annals of Neurology · doi:10.1002/ana.24135 · Cited by 891 · see citing works
Understanding the impact of sex and gender in Alzheimer’s disease: A call to action
Nebel, R. A., Aggarwal, N. T., Barnes, L. L., Gallagher, A., Goldstein, J. M., Kantarci, K., Mallampalli, M. P., Mormino, E. C., Scott, L., Yu, W. H., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.04.008 · Cited by 839 · see citing works
Self-citationChronic Kidney Disease Awareness, Prevalence, and Trends among U.S. Adults, 1999 to 2000
Coresh, J., Byrd-Holt, D. D., Astor, B. C., Briggs, J. P., Eggers, P. W., Lacher, D. A., & Hostetter, T. H. (2004) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004070539 · Cited by 837 · see citing works
Prevention and Control of Influenza
(1985) · Annals of Internal Medicine · doi:10.7326/0003-4819-103-4-560 · Cited by 809 · see citing works
Ischemia and No Obstructive Coronary Artery Disease (INOCA)
Merz, C. N. B., Pepine, C. J., Walsh, M. N., Fleg, J. L., Camici, P. G., Chilian, W. M., Clayton, J. A., Cooper, L. S., Crea, F., Carli, M. F. D., et al. (2017) · Circulation · doi:10.1161/circulationaha.116.024534 · Cited by 752 · see citing works
Sex differences and stress across the lifespan
Bale, T. L., & Epperson, C. N. (2015) · Nature Neuroscience · doi:10.1038/nn.4112 · Cited by 751 · see citing works
Self-citationSex-specific transcriptional signatures in human depression
Labonté, B., Engmann, O., Purushothaman, I., Menard, C., Wang, J., Tan, C., Scarpa, J. R., Moy, G., Loh, Y.-H. E., Cahill, M., et al. (2017) · Nature Medicine · doi:10.1038/nm.4386 · Cited by 748 · see citing works
Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes
Regitz‐Zagrosek, V., Oertelt‐Prigione, S., Prescott, E., Franconi, F., Gerdts, E., Foryst‐Ludwig, A., Maas, A. H. E. M., Kautzky‐Willer, A., Knappe-Wegner, D., Kintscher, U., et al. (2015) · European Heart Journal · doi:10.1093/eurheartj/ehv598 · Cited by 744 · see citing works
Self-citationMechanistic Pathways of Sex Differences in Cardiovascular Disease
Regitz‐Zagrosek, V., & Kararigas, G. (2016) · Physiological Reviews · doi:10.1152/physrev.00021.2015 · Cited by 738 · see citing works
Self-citationSex differences in the epidemiology, clinical features, and pathophysiology of migraine
Vetvik, K. G., & MacGregor, E. A. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30293-9 · Cited by 732 · see citing works
Benedix, F., Kube, R., Meyer, F. P., Schmidt, U., Gastinger, I., & Lippert, H. (2010) · Diseases of the Colon & Rectum · doi:10.1007/dcr.0b013e3181c703a4 · Cited by 714 · see citing works
Peters, S. A. E., Huxley, R. R., & Woodward, M. (2014) · Diabetologia · doi:10.1007/s00125-014-3260-6 · Cited by 701 · see citing works
Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis
Neu, S. C., Pa, J., Kukull, W., Beekly, D., Kuzma, A., Gangadharan, P., Wang, L.-S., Romero, K., Arneric, S. P., Redolfi, A., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.2188 · Cited by 674 · see citing works
Patient–physician gender concordance and increased mortality among female heart attack patients
Greenwood, B. N., Carnahan, S., & Huang, L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800097115 · Cited by 631 · see citing works
Sexual differentiation of the vertebrate nervous system
Morris, J. A., Jordan, C. L., & Breedlove, S. M. (2004) · Nature Neuroscience · doi:10.1038/nn1325 · Cited by 627 · see citing works
Age, APOE and sex: triad of risk of Alzheimer’s disease.
Riedel, B. C., Thompson, P. M., & Brinton, R. D. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.012 · Cited by 627 · see citing works
Self-citationArnold, A. P. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.03.011 · Cited by 625 · see citing works
Perimenopause as a neurological transition state
Brinton, R. D., Yao, J., Yin, F., Mack, W. J., & Cadenas, E. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.82 · Cited by 612 · see citing works
Self-citationSex and gender analysis improves science and engineering
Tannenbaum, C., Ellis, R. P., Eyssel, F., Zou, J., & Schiebinger, L. L. (2019) · Nature · doi:10.1038/s41586-019-1657-6 · Cited by 587 · see citing works
Prevalence of suicide ideation and suicide attempts in nine countries
Weissman, M. M., Bland, R. C., CANINO, G. J., Greenwald, S., Hwu, H., Joyce, P. R., Karam, E. G., Lee, C.-Y., Lellouch, J., Lépine, J., et al. (1999) · Psychological Medicine · doi:10.1017/s0033291798007867 · Cited by 583 · see citing works
Gender equality in science, medicine, and global health: where are we at and why does it matter?
Shannon, G. D., Jansen, M., Williams, K., Cáceres, C. F., Motta, A., Odhiambo, A., Eleveld, A., & Mannell, J. (2019) · The Lancet · doi:10.1016/s0140-6736(18)33135-0 · Cited by 554 · see citing works
Reís, S. E., Holubkov, R., Smith, A. J. C., et al. (2001) · American Heart Journal · doi:10.1067/mhj.2001.114198 · Cited by 551 · see citing works
Johnson, J. L., Greaves, L., & Repta, R. (2009) · International Journal for Equity in Health · doi:10.1186/1475-9276-8-14 · Cited by 534 · see citing works
Kendler, K. S., Thornton, L. M., & Prescott, C. A. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.4.587 · Cited by 520 · see citing works
Deaths: Leading Causes for 2017.
Heron, M. P. (2019) · PubMed · Cited by 519 · see citing works
The Epigenetics of Sex Differences in the Brain: Figure 1.
McCarthy, M. M., Auger, A. P., Bale, T. L., Vries, G. J. D., Dunn, G. A., Forger, N. G., Murray, E. K., Nugent, B. M., Schwarz, J. M., & Wilson, M. E. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3331-09.2009 · Cited by 478 · see citing works
Bots, S. H., Peters, S. A. E., & Woodward, M. (2017) · BMJ Global Health · doi:10.1136/bmjgh-2017-000298 · Cited by 477 · see citing works
(2004) · PsycEXTRA Dataset · doi:10.1037/e548622006-001 · Cited by 472 · see citing works
Association of Premature Natural and Surgical Menopause With Incident Cardiovascular Disease
Honigberg, M. C., Zekavat, S. M., Aragam, K. G., Finneran, P., Klarin, D. M., Bhatt, D. L., Januzzi, J. L., Scott, N. S., & Natarajan, P. (2019) · JAMA · doi:10.1001/jama.2019.19191 · Cited by 470 · see citing works
Mortality Trends in Men and Women with Diabetes, 1971 to 2000
Gregg, E. W., Gu, Q., Cheng, Y. J., Narayan, K. M. V., & Cowie, C. C. (2007) · Annals of Internal Medicine · doi:10.7326/0003-4819-147-3-200708070-00167 · Cited by 463 · see citing works
Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias
Dunford, A. J., Weinstock, D. M., Savova, V., Schumacher, S. E., Cleary, J. P., Yoda, A., Sullivan, T. J., Hess, J. M., Gimelbrant, A. A., Beroukhim, R., et al. (2016) · Nature Genetics · doi:10.1038/ng.3726 · Cited by 459 · see citing works
Representation of Women in Randomized Clinical Trials of Cardiovascular Disease Prevention
Melloni, C., Berger, J. S., Wang, T. Y., Gunes, F., Stebbins, A., Pieper, K. S., Dolor, R. J., Douglas, P. S., Mark, D. B., & Newby, L. K. (2010) · Circulation: Cardiovascular Quality and Outcomes · doi:10.1161/circoutcomes.110.868307 · Cited by 455 · see citing works
Poor Outcome After First-Ever Stroke
Appelros, P., Nydevik, I., & Viitanen, M. H. (2003) · Stroke · doi:10.1161/01.str.0000047852.05842.3c · Cited by 436 · see citing works
Prevalence and severity of DSM‐5 eating disorders in a community cohort of adolescents
Smink, F. R. E., van Hoeken, D., Oldehinkel, A. J., & Hoek, H. W. (2014) · International Journal of Eating Disorders · doi:10.1002/eat.22316 · Cited by 415 · see citing works
Gender differences in glucose homeostasis and diabetes
Mauvais-Jarvis, F. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.08.016 · Cited by 377 · see citing works
Self-citationBuckley, R. F., Mormino, E. C., Rabin, J. S., Hohman, T. J., Landau, S., Hanseeuw, B. J., Jacobs, H. I. L., Papp, K. V., Amariglio, R. E., Properzi, M. J., et al. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2018.4693 · Cited by 373 · see citing works
Sex differences in cancer mechanisms
Rubin, J. B., Lagas, J. S., Broestl, L., Sponagel, J., Rockwell, N., Rhee, G., Rosen, S. F., Chen, S., Klein, R. S., Imoukhuede, P. I., et al. (2020) · Biology of Sex Differences · doi:10.1186/s13293-020-00291-x · Cited by 369 · see citing works
Self-citationClocchiatti, A., Cora, E., Zhang, Y., & Dotto, G. P. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.30 · Cited by 368 · see citing works
Sex differences in risk factors for myocardial infarction: cohort study of UK Biobank participants
Millett, E. R. C., Peters, S. A. E., & Woodward, M. (2018) · BMJ · doi:10.1136/bmj.k4247 · Cited by 365 · see citing works
Studying both sexes: a guiding principle for biomedicine
Clayton, J. A. (2016) · The FASEB Journal · doi:10.1096/fj.15-279554 · Cited by 358 · see citing works
Sex differences in the burden of type 2 diabetes and cardiovascular risk across the life course
Huebschmann, A. G., Huxley, R., Kohrt, W. M., Zeitler, P. S., Regensteiner, J. G., & Reusch, J. E. B. (2019) · Diabetologia · doi:10.1007/s00125-019-4939-5 · Cited by 354 · see citing works
Self-citationSex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data
Yang, W., Warrington, N. M., Taylor, S. J., Whitmire, P., Carrasco, E., Singleton, K., Wu, N., Lathia, J. D., Berens, M. E., Kim, A. H., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aao5253 · Cited by 346 · see citing works
Self-citationMauvais-Jarvis, F., Manson, J. E., Stevenson, J. C., & Fonseca, V. A. (2017) · Endocrine Reviews · doi:10.1210/er.2016-1146 · Cited by 341 · see citing works
Self-citationSex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau
Hohman, T. J., Dumitrescu, L., Barnes, L. L., Thambisetty, M., Beecham, G., Kunkle, B., Gifford, K. A., Bush, W. S., Chibnik, L. B., Mukherjee, S., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2018.0821 · Cited by 340 · see citing works
Mauvais-Jarvis, F. (2011) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2010.10.002 · Cited by 335 · see citing works
Self-citationRegensteiner, J. G., Golden, S., Huebschmann, A. G., Barrett-Connor, E., Chang, A. Y., Chyun, D., Fox, C. S., Kim, C., Mehta, N., Reckelhoff, J. F., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000343 · Cited by 334 · see citing works
Self-citationSex differences in the psychopharmacological treatment of depression
Sramek, J. J., Murphy, M. F., & Cutler, N. R. (2016) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2016.18.4/ncutler · Cited by 334 · see citing works
Half- vs Full-Dose Trivalent Inactivated Influenza Vaccine (2004-2005)
Engler, R. J. M. (2008) · Archives of Internal Medicine · doi:10.1001/archinternmed.2008.513 · Cited by 319 · see citing works
AISF position paper on nonalcoholic fatty liver disease (NAFLD): Updates and future directions
Lonardo, A., Nascimbeni, F., Targher, G., Bernardi, M., Bonino, F., Bugianesi, E., Casini, A., Gastaldelli, A., Marchesini, G., Marra, F., et al. (2017) · Digestive and Liver Disease · doi:10.1016/j.dld.2017.01.147 · Cited by 306 · see citing works
Self-citationGELLER, S. E., Koch, A. R., Roesch, P., Filut, A., Hallgren, E., & Carnes, M. L. (2017) · Academic Medicine · doi:10.1097/acm.0000000000002027 · Cited by 306 · see citing works
Narrative Review: Ketosis-Prone Type 2 Diabetes Mellitus
Umpierrez, G. E., Smiley, D., & Kitabchi, A. E. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-5-200603070-00011 · Cited by 299 · see citing works
A general theory of sexual differentiation
Arnold, A. P. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23884 · Cited by 292 · see citing works
Defining and measuring gender: A social determinant of health whose time has come
Phillips, S. P. (2005) · International Journal for Equity in Health · doi:10.1186/1475-9276-4-11 · Cited by 291 · see citing works
Sex Versus Gender-Related Characteristics
Pelletier, R., Khan, N. A., Cox, J., Daskalopoulou, S. S., Eisenberg, M. J., Bacon, S. L., Lavoie, K. L., Daskupta, K., Rabi, D., Humphries, K. H., et al. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2015.10.067 · Cited by 291 · see citing works
Hecking, M., Bieber, B. A., Ethier, J. H., Kautzky‐Willer, A., Sunder–Plassmann, G., Säemann, M. D., Ramirez, S. P. B., Gillespie, B. W., Pisoni, R. L., Robinson, B. M., et al. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001750 · Cited by 285 · see citing works
Therapeutic implications of the gender-specific aspects of cardiovascular disease
Regitz‐Zagrosek, V. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2032 · Cited by 282 · see citing works
Self-citationA Guide for the Design of Pre-clinical Studies on Sex Differences in Metabolism
Mauvais‐Jarvis, F., Arnold, A. P., & Reue, K. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.04.033 · Cited by 279 · see citing works
Self-citationOhkuma, T., Komorita, Y., Peters, S. A. E., & Woodward, M. (2019) · Diabetologia · doi:10.1007/s00125-019-4926-x · Cited by 279 · see citing works
Knowledge, Attitudes, and Beliefs Regarding Cardiovascular Disease in Women
Bairey Merz, C. N., Andersen, H., Sprague, E., Burns, A., Keida, M., Walsh, M. N., Greenberger, P., Campbell, S., Pollin, I., McCullough, C., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2017.05.024 · Cited by 267 · see citing works
Marcus, S. M., Kerber, K. B., Rush, A. J., Wisniewski, S. R., Nierenberg, A., Balasubramani, G. K., Ritz, L., Kornstein, S., Young, E. A., & Trivedi, M. H. (2008) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2007.06.012 · Cited by 266 · see citing works
Santema, B. T., Ouwerkerk, W., Tromp, J., Sama, I. E., Ravera, A., Regitz‐Zagrosek, V., Hillege, H. L., Samani, N. J., Zannad, F. M., Dickstein, K., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31792-1 · Cited by 259 · see citing works
Self-citationCummings, S. R., Cawthon, P. M., Ensrud, K. E., Cauley, J. A., Fink, H. A., & ORWOLL, E. S. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060708 · Cited by 249 · see citing works
Biological sex affects vaccine efficacy and protection against influenza in mice
Fink, A. L., Engle, K., Ursin, R. L., Tang, W., & Klein, S. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805268115 · Cited by 246 · see citing works
Self-citationGuy, J. E., & Peters, M. G. (2013) · Europe PMC (PubMed Central) · Cited by 244 · see citing works
Sex Differences in Reperfusion in Young Patients With ST-Segment–Elevation Myocardial Infarction
D’Onofrio, G., Safdar, B., Lichtman, J. H., Strait, K. M., Dreyer, R. P., Geda, M. E., Spertus, J. A., & Krumholz, H. M. (2015) · Circulation · doi:10.1161/circulationaha.114.012293 · Cited by 239 · see citing works
Sex inclusion in basic research drives discovery
Klein, S. L., Schiebinger, L., Stefanick, M. L., Cahill, L., Danska, J., de Vries, G. J., Kibbe, M. R., McCarthy, M. M., Mogil, J. S., Woodruff, T. K., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1502843112 · Cited by 238 · see citing works
Self-citationForeman, M. G., Zhang, L., Murphy, J. R., Hansel, N. N., Make, B. J., Hokanson, J. E., Washko, G. R., Regan, E. A., Crapo, J. D., Silverman, E. K., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201011-1928oc · Cited by 237 · see citing works
Self-citationRegression of Myocardial Hypertrophy After Aortic Valve Replacement
Petrov, G., Regitz‐Zagrosek, V., Lehmkuhl, E., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.927764 · Cited by 231 · see citing works
Self-citationSex Bias in Asthma Prevalence and Pathogenesis
Shah, R., & Newcomb, D. C. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02997 · Cited by 228 · see citing works
Sex differences in antidepressant efficacy
LeGates, T. A., Kvarta, M. D., & Thompson, S. M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0156-z · Cited by 225 · see citing works
Wannamethee, S. G., Papacosta, O., Lawlor, D. A., Whincup, P. H., Lowe, G. D. O., Ebrahim, S. B. J., & Sattar, N. A. (2011) · Diabetologia · doi:10.1007/s00125-011-2284-4 · Cited by 224 · see citing works
Pelletier, R., Ditto, B., & Pilote, L. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000186 · Cited by 223 · see citing works
The landscape of genomic imprinting across diverse adult human tissuesPreprint
Baran, Y., Subramaniam, M., Biton, A., Tukiainen, T., Tsang, E. K., Rivas, M. A., Pirinen, M., Gutiérrez‐Arcelus, M., Smith, K. S., Kukurba, K., et al. (2015) · Genome Research · doi:10.1101/gr.192278.115 · Cited by 219 · see citing works
Delayed Care and Mortality Among Women and Men With Myocardial Infarction
Bugiardini, R., Ricci, B., Cenko, E., Vasiljević, Z., Kedev, S. A., Davidović, G., Zdravkovic, M. D., Miličić, D., Dilić, M., Manfrini, O., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.005968 · Cited by 219 · see citing works
Postischemic Estrogen Reduces Hypoperfusion and Secondary Ischemia After Experimental Stroke
McCullough, L. D., Alkayed, N. J., Traystman, R. J., Williams, M. J., & Hurn, P. D. (2001) · Stroke · doi:10.1161/01.str.32.3.796 · Cited by 211 · see citing works
Self-citationShanmugan, S., & Epperson, C. N. (2012) · Human Brain Mapping · doi:10.1002/hbm.22218 · Cited by 210 · see citing works
Self-citationGender medicine and oncology: report and consensus of an ESMO workshop
Wagner, A. D., Oertelt‐Prigione, S., Adjei, A. A., Buclin, T., Cristina, V., Csajka, C., Coukos, G., Dafni, U., Dotto, G. P., Ducreux, M. P., et al. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz414 · Cited by 209 · see citing works
Sex Disparities in the Treatment and Control of Cardiovascular Risk Factors in Type 2 Diabetes
Gouni‐Berthold, I., Berthold, H. K., Mantzoros, C. S., Böhm, M., & Krone, W. (2008) · Diabetes Care · doi:10.2337/dc08-0194 · Cited by 190 · see citing works
Perimenopause and emergence of an Alzheimer’s bioenergetic phenotype in brain and periphery
Mosconi, L., Berti, V., Quinn, C. G., McHugh, P. F., Petrongolo, G., Osorio, R. S., Connaughty, C., Pupi, A., Vallabhajosula, S., Isaacson, R., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0185926 · Cited by 185 · see citing works
Self-citationNoninsulin‐Dependent diabetes mellitus in black and white Americans
Harris, M. I. (1990) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610060202 · Cited by 183 · see citing works
Late Initiation of Dialysis among Women and Ethnic Minorities in the United States
Kausz, A. T., Obrador, G. T., Arora, P., Ruthazer, R., Levey, A. S., & Pereira, B. J. G. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v11122351 · Cited by 183 · see citing works
Potluri, T., Fink, A. L., Sylvia, K. E., Dhakal, S., Vermillion, M. S., Steeg, L. G. V., Deshpande, S., Narasimhan, H., & Klein, S. L. (2019) · npj Vaccines · doi:10.1038/s41541-019-0124-6 · Cited by 182 · see citing works
Self-citationThe Role of X Inactivation and Cellular Mosaicism in Women's Health and Sex-Specific Diseases
Migeon, B. R. (2006) · JAMA · doi:10.1001/jama.295.12.1428 · Cited by 180 · see citing works
Jurado-Coronel, J. C., Cabezas, R., Ávila Rodríguez, M. F., Echeverria, V., García-Segura, L. M., & Barreto, G. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.09.002 · Cited by 180 · see citing works
Peters, S. A. E., Huxley, R., Sattar, N. A., & Woodward, M. (2015) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-015-0462-5 · Cited by 176 · see citing works
Gendered Manifestations of Depression and Help Seeking Among Men
Call, J. B., & Shafer, K. M. (2015) · American Journal of Men s Health · doi:10.1177/1557988315623993 · Cited by 176 · see citing works
McCartney, G., Mahmood, L., Leyland, A. H., Batty, G. D., & Hunt, K. (2011) · Tobacco Control · doi:10.1136/tc.2010.037929 · Cited by 166 · see citing works
Yassin, A., Haider, A., Haider, K. S., Caliber, M., Doros, G., Saad, F., & Garvey, W. T. (2019) · Diabetes Care · doi:10.2337/dc18-2388 · Cited by 164 · see citing works
A midlife stroke surge among women in the United States
Towfighi, A., Saver, J. L., Engelhardt, R., & Ovbiagele, B. I. (2007) · Neurology · doi:10.1212/01.wnl.0000268491.89956.c2 · Cited by 163 · see citing works
Women and Lung Disease. Sex Differences and Global Health Disparities
Pinkerton, K. E., Harbaugh, M., Han, M. K., Saux, C. J. L., Winkle, L. S. V., Martin, W. J., Kosgei, R. J., Carter, E. J., Zelin, N. S., Smiley‐Jewell, S. M., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201409-1740pp · Cited by 163 · see citing works
Sexually dimorphic RB inactivation underlies mesenchymal glioblastoma prevalence in males
Sun, T., Warrington, N. M., Luo, J. R., Brooks, M. D., Dahiya, S. M., Snyder, S. C., Sengupta, R., & Rubin, J. B. (2014) · Journal of Clinical Investigation · doi:10.1172/jci71048 · Cited by 162 · see citing works
Self-citationHand washing practices in a college town environment.
Borchgrevink, C. P., Cha, J., & Kim, S. (2013) · PubMed · Cited by 160 · see citing works
Sundermann, E. E., Initiative, A. D. N., Biegon, A. R., Rubin, L. H., Lipton, R. B., Landau, S. M., & Maki, P. M. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160716 · Cited by 159 · see citing works
Self-citationHeritability of Perinatal Depression and Genetic Overlap With Nonperinatal Depression
Viktorin, A., Meltzer-Brody, S. E., Kuja‐Halkola, R., Sullivan, P. F., Landén, M., Lichtenstein, P., & Magnusson, P. K. E. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.15010085 · Cited by 152 · see citing works
Effect of early-onset preeclampsia on cardiovascular risk in the fifth decade of life
Bokslag, A., Teunissen, P. W., Franssen, C., van Kesteren, F., Otto Kamp, B., Ganzevoort, W., Paulus, W. J., & de Groot, C. J. M. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.02.015 · Cited by 152 · see citing works
Sex hormones and their influence on chronic kidney disease
Valdivielso, J. M., Jacobs-Cachá, C., & Soler, M. J. (2018) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000463 · Cited by 152 · see citing works
Sex differences in the risk of vascular disease associated with diabetes
de Ritter, R., de Jong, M., Vos, R. C., Kallen, C., Sep, S. J. S., Woodward, M., Stehouwer, C. D. A., Bots, M. L., & Peters, S. A. E. (2020) · Biology of Sex Differences · doi:10.1186/s13293-019-0277-z · Cited by 151 · see citing works
Stroke in women — from evidence to inequalities
the Women Initiative for Stroke in Europe (WISE) group, Cordonnier, C., Sprigg, N., Sandset, E. C., Pavlovic, A. M., Sunnerhagen, K. S., Caso, V., & Christensen, H. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.95 · Cited by 147 · see citing works
Prevalence and recognition of chronic kidney disease in Stockholm healthcare
Gasparini, A., Evans, M., Coresh, J., Grams, M. E., Norin, O., Qureshi, A. R., Runesson, B., Barany, P. F., Ärnlöv, J., Jernberg, T., et al. (2016) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfw354 · Cited by 146 · see citing works
Self-citationGender-related differences in lifestyle may affect health status.
Varı́, R., Scazzocchio, B., d’Amore, A., Giovannini, C., Gessani, S., & Masella, R. (2016) · Annali dell Istituto Superiore di Sanità · doi:10.4415/ann_16_02_06 · Cited by 143 · see citing works
Postprandial Variations of Plasma Inflammatory Markers in Abdominally Obese Men
Blackburn, P., Després, J., Lamarche, B., Tremblay, A., Bergeron, J., Lemieux, I., & Couillard, C. (2006) · Obesity · doi:10.1038/oby.2006.201 · Cited by 140 · see citing works
Dennis, J., Henley, W., Weedon, M. N., Lonergan, M. E., Rodgers, L. R., Jones, A. G., Hamilton, W. T., Sattar, N. A., Janmohamed, S. G., Holman, R. R., et al. (2018) · Diabetes Care · doi:10.2337/dc18-0344 · Cited by 134 · see citing works
Ma, M., Dorstyn, D., Ward, L., & Prentice, S. (2018) · Aging & Mental Health · doi:10.1080/13607863.2017.1370689 · Cited by 133 · see citing works
Kt/V underestimates the hemodialysis dose in women and small men
Spalding, E. M., Chandna, S. M., Davenport, A., & Farrington, K. (2008) · Kidney International · doi:10.1038/ki.2008.185 · Cited by 122 · see citing works
Sex and Gender Differences in Pharmacology
Regitz‐Zagrosek, V. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-30726-3 · Cited by 121 · see citing works
Self-citationGene Regulatory Network Analysis Identifies Sex-Linked Differences in Colon Cancer Drug Metabolism
Lopes‐Ramos, C. M., Kuijjer, M. L., Ogino, S., Fuchs, C. S., DeMeo, D. L., Glass, K., & Quackenbush, J. F. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0454 · Cited by 120 · see citing works
Self-citationAssari, S., Lankarani, M. M., & Burgard, S. A. (2015) · Annals of Epidemiology · doi:10.1016/j.annepidem.2015.11.006 · Cited by 119 · see citing works
Editorial policies for sex and gender analysis
Schiebinger, L. L., Leopold, S. S., & Miller, V. M. (2016) · The Lancet · doi:10.1016/s0140-6736(16)32392-3 · Cited by 118 · see citing works
Lonardo, A., Mantovani, A., Lugari, S., & Targher, G. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112841 · Cited by 117 · see citing works
Self-citationSex ratio among childhood cancers by single year of age
Williams, L. A., Richardson, M. R., Marcotte, E. L., Poynter, J. N., & Spector, L. G. (2019) · Pediatric Blood & Cancer · doi:10.1002/pbc.27620 · Cited by 114 · see citing works
Covella, B., Vinturache, A., Cabiddu, G., Attini, R., Gesualdo, L., Versino, E., & Piccoli, G. B. (2019) · Kidney International · doi:10.1016/j.kint.2019.03.033 · Cited by 114 · see citing works
Sex and inflammation in respiratory diseases: a clinical viewpoint
Casimir, G. J. A., Lefèvre, N., Corazza, F., & Duchateau, J. (2013) · Biology of Sex Differences · doi:10.1186/2042-6410-4-16 · Cited by 113 · see citing works
The impact of sex, gender and pregnancy on 2009 H1N1 disease
Klein, S. L., Passaretti, C. L., Anker, M., Olukoya, P., & Pekosz, A. S. (2010) · Biology of Sex Differences · doi:10.1186/2042-6410-1-5 · Cited by 112 · see citing works
Self-citationPetrov, G., Dworatzek, E., Schulze, T. M., Dandel, M., Kararigas, G., Mahmoodzadeh, S., Knosalla, C., Hetzer, R., & Regitz‐Zagrosek, V. (2014) · JACC. Cardiovascular imaging · doi:10.1016/j.jcmg.2014.06.017 · Cited by 111 · see citing works
Self-citationWomen manifest more severe COPD symptoms across the life course
DeMeo, D. L., Ramagopalan, S. V., Kavati, A., et al. (2018) · International Journal of COPD · doi:10.2147/copd.s160270 · Cited by 109 · see citing works
Self-citationFactors influencing sex differences in poststroke functional outcome
Lisabeth, L. D., Reeves, M. J., Baek, J., Skolarus, L. E., Brown, D. L., Zahuranec, D. B., Smith, M. A., & Morgenstern, L. B. (2015) · Stroke · doi:10.1161/strokeaha.114.007985 · Cited by 108 · see citing works
Sex and Gender Differences in Clinical Medicine
Regitz‐Zagrosek, V., & Seeland, U. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-30726-3_1 · Cited by 107 · see citing works
Self-citationEvaluation of Gender Differences in Door-to-Balloon Time in ST-Elevation Myocardial Infarction
Dreyer, R. P., Beltrame, J. F., Tavella, R., et al. (2013) · Heart Lung and Circulation · doi:10.1016/j.hlc.2013.03.078 · Cited by 105 · see citing works
Sex-related physiology of the preimplantation embryo
Gardner, D. K., Larman, M. G., & Thouas, G. A. (2010) · Molecular Human Reproduction · doi:10.1093/molehr/gaq042 · Cited by 104 · see citing works
Sex Differences in Outcome After Endovascular Stroke Therapy for Acute Ischemic Stroke
Sheth, S. A., Lee, S., Warach, S. J., Gralla, J., Jahan, R., Goyal, M., Nogueira, R. G., Zaidat, O. O., Pereira, V. M., Siddiqui, A. H., et al. (2019) · Stroke · doi:10.1161/strokeaha.118.023867 · Cited by 104 · see citing works
Self-citationSex-specific norms for verbal memory tests may improve diagnostic accuracy of amnestic MCI
Sundermann, E. E., Maki, P. M., Biegon, A. R., Lipton, R. B., Mielke, M. M., Machulda, M. M., Bondi, M. W., & Initiative, A. D. N. (2019) · Neurology · doi:10.1212/wnl.0000000000008467 · Cited by 102 · see citing works
Self-citationGender influences handwashing rates in the critical care unit
van de Mortel, T., Bourke, R., McLoughlin, J., Nonu, M., & Reis, M. (2001) · American Journal of Infection Control · doi:10.1067/mic.2001.119511 · Cited by 100 · see citing works
Morton, R. L., Turner, R. M., Howard, K., Snelling, P. L., & Webster, A. C. (2011) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2011.08.024 · Cited by 97 · see citing works
Epperson, C. N., Sammel, M. D., Bale, T. L., Kim, D. R., Conlin, S. E., Scalice, S., Freeman, K., & Freeman, E. W. (2017) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.16m10662 · Cited by 96 · see citing works
Self-citationBarcena, M. L., Pozdniakova, S., Kühl, A. A., Baczkó, I., Ladilov, Y. V., & Regitz‐Zagrosek, V. (2019) · Aging · doi:10.18632/aging.101881 · Cited by 92 · see citing works
Self-citationCanevelli, M., Quarata, F., Remiddi, F., Lucchini, F., Lacorte, E., Vanacore, N., Bruno, G., & Cesari, M. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.035 · Cited by 88 · see citing works
The intersection of sex and gender in the treatment of influenza
Morgan, R., & Klein, S. L. (2019) · Current Opinion in Virology · doi:10.1016/j.coviro.2019.02.009 · Cited by 85 · see citing works
Self-citationSex Differences in Long-Term Quality of Life Among Survivors After Stroke in the INSTRUCT
Phan, H., Blizzard, C. L., Reeves, M. J., Thrift, A. G., Cadilhac, D. A.-M., Sturm, J. W., Heeley, E. L., Otáhal, P., Rothwell, P. M., Anderson, C. S., et al. (2019) · Stroke · doi:10.1161/strokeaha.118.024437 · Cited by 85 · see citing works
Venous access: Women are equal
Caplin, N. J., Sedlacek, M., Teodorescu, V. J., et al. (2003) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2003.50052 · Cited by 82 · see citing works
Wei, J., Mehta, P. K., Grey, E., Garberich, R., Hauser, R. G., Merz, C. N. B., & Henry, T. D. (2017) · American Heart Journal · doi:10.1016/j.ahj.2017.06.005 · Cited by 78 · see citing works
Sex-specific features of emphysema among current and former smokers with COPD
Hardin, M. E., Foreman, M. G., Dransfield, M. T., Hansel, N. N., Han, M. K., Cho, M. H., Bhatt, S. P., Ramsdell, J., Lynch, D. A., Curtis, J. L., et al. (2015) · European Respiratory Journal · doi:10.1183/13993003.00996-2015 · Cited by 77 · see citing works
Self-citationAge and testosterone mediate influenza pathogenesis in male mice
Steeg, L. G. V., Vermillion, M. S., Hall, O. J., Alam, O., McFarland, R., Chen, H., Zirkin, B. R., & Klein, S. L. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00352.2016 · Cited by 77 · see citing works
Self-citationGiacobini, E., & Pepeu, G. (2018) · Current Alzheimer Research · doi:10.2174/1567205015666180613111504 · Cited by 77 · see citing works
Sexual dimorphism in glioma glycolysis underlies sex differences in survival
Ippolito, J. E., Yim, A. K., Luo, J. R., Chinnaiyan, P., & Rubin, J. B. (2017) · JCI Insight · doi:10.1172/jci.insight.92142 · Cited by 73 · see citing works
Self-citationAsthma over the Adult Life Course
Zein, J., Denson, J. L., & Wechsler, M. E. (2018) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2018.10.009 · Cited by 69 · see citing works
Chua, H., Tsuei, D., Lee, P., Jeng, Y., Lu, J., Wu, J., Su, D., Chen, Y., Chien, C., Kao, P., et al. (2015) · Hepatology · doi:10.1002/hep.27996 · Cited by 66 · see citing works
Syamlal, G., Doney, B. C., & Mazurek, J. M. (2019) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6813a2 · Cited by 64 · see citing works
Roswell, R. O., Kunkes, J., Chen, A. Y., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004521 · Cited by 62 · see citing works
Delbridge, A. R. D., Kueh, A. J., Ke, F., Zamudio, N., El-Saafin, F., Jansz, N., Wang, G., Iminitoff, M., Beck, T. J., Haupt, S., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.048 · Cited by 61 · see citing works
Du, T., Fernandez, C., Barshop, R., Guo, Y., Krousel-Wood, M. A., Chen, W., Qi, L., Harville, E. W., Mauvais‐Jarvis, F., Fonseca, V. A., et al. (2019) · Diabetes Care · doi:10.2337/dc18-2029 · Cited by 59 · see citing works
Self-citationSex Differences in Clinical Outcomes After Premature Acute Coronary Syndrome
Pelletier, R., Choi, J., Winters, N., Eisenberg, M. J., Bacon, S., Cox, J. L., Daskalopoulou, S. S., Lavoie, K., Karp, I., Shimony, A., et al. (2016) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2016.05.018 · Cited by 57 · see citing works
Kanchi, R., Perlman, S. E., Chernov, C., Wu, W. Y., Tabaei, B. P., Trinh‐Shevrin, C., Islam, N. S., Seixas, A. A., Rodriguez-Lopez, J. S., & Thorpe, L. E. (2018) · Journal of Urban Health · doi:10.1007/s11524-018-0287-x · Cited by 55 · see citing works
Francis, M. D., & Valent, D. J. (2007) · PubMed · Cited by 55 · see citing works
Carrasquilla, G. D., Frumento, P., Berglund, A., Borgfeldt, C., Bottai, M., Chiavenna, C., Eliasson, M., Engström, G., Hallmans, G., Jansson, J., et al. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002445 · Cited by 55 · see citing works
Risk factors for subarachnoid haemorrhage: a nationwide cohort of 950 000 adults
Sundström, J., Söderholm, M., Söderberg, S., et al. (2019) · International Journal of Epidemiology · doi:10.1093/ije/dyz163 · Cited by 54 · see citing works
Production of amphiregulin and recovery from influenza is greater in males than females
Vermillion, M. S., Ursin, R. L., Kuok, D. I. T., Steeg, L. G. V., Wohlgemuth, N., Hall, O. J., Fink, A. L., Sasse, E., Nelson, A., Ndeh, R., et al. (2018) · Biology of Sex Differences · doi:10.1186/s13293-018-0184-8 · Cited by 53 · see citing works
Self-citationThe State of Men's Health in Europe
White, A., de Sousa, B., de Visser, R. O., Hogston, R., Madsen, S. A., MAKARA, P., Richardson, N., & Zatoński, W. A. (2011) · Figshare · doi:10.2772/61323 · Cited by 52 · see citing works
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Melberg, T., Kindervaag, B., & Rosland, J. (2013) · American Heart Journal · doi:10.1016/j.ahj.2013.07.034 · Cited by 50 · see citing works
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Li, Y., Xu, A., Jia, S., & Huang, J. (2019) · Oncology Letters · doi:10.3892/ol.2019.10127 · Cited by 47 · see citing works
Mahmoud, K. D., Gu, Y. L., Nijsten, M. W., et al. (2013) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872613481449 · Cited by 46 · see citing works
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Florio, A. A., Graubard, B. I., Yang, B., Thistle, J. E., Bradley, M. C., McGlynn, K. A., & Petrick, J. L. (2019) · European Journal of Epidemiology · doi:10.1007/s10654-019-00526-1 · Cited by 40 · see citing works
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Stolz, D., Κostikas, Κ., Loefroth, E., et al. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.04.107 · Cited by 39 · see citing works
Danska, J. S. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009859 · Cited by 36 · see citing works
Scavini, M., & Piemonti, L. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3576790 · Cited by 35 · see citing works
Li, X., Obeidat, M., Zhou, G., Leung, J. M., Tashkin, D. P., Wise, R. A., Connett, J. E., Joubert, P., Bossé, Y., van den Berge, M., et al. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.020 · Cited by 33 · see citing works
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Howe, M. D., & McCullough, L. D. (2015) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2015.1020300 · Cited by 28 · see citing works
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Fraticelli, L., Freyssenge, J., Claustre, C., et al. (2019) · Cerebrovascular Diseases · doi:10.1159/000500901 · Cited by 21 · see citing works
Sun, Y., Mironova, V., Chen, Y., Lundh, E. P. F., Zhang, Q., Cai, Y. A., Vasiliou, V., Zhang, Y., García-Milian, R., Khan, S. A., et al. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.09.004 · Cited by 18 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [41]Regitz-Zagrosek V Oertelt-Prigione S Prescott E Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes Eur Heart J 37 2016 24 34 26530104
- [126]Benjamin EJ Muntner P Alonso A Heart disease and stroke statistics—2019 update: a report from the American Heart Association Circulation 139 2019 e56 e528 30700139
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- Authors
- Mauvais-Jarvis, F., Bairey Merz, N., Barnes, P. J., Brinton, R. D., Carrero, J.-J., DeMeo, D. L., De Vries, G. J., Epperson, C. N., Govindan, R., Klein, S. L., Lonardo, A., Maki, P. M., McCullough, L. D., Regitz-Zagrosek, V., Regensteiner, J. G., Rubin, J. B., Sandberg, K., & Suzuki, A.
- Affiliations
- Imperial College London (GB)
- University of Arizona (US)
- Brigham and Women's Hospital (US)
- University of Colorado Anschutz (US)
- Washington University in St. Louis (US)
- Johns Hopkins University (US)
- University of Modena and Reggio Emilia (IT)
- University of Illinois Chicago (US)
- The University of Texas Health Science Center at Houston (US)
- Georgetown University (US)
- Duke Medical Center (US)
- ORCID
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 396
- Issue
- 10250
- Pages
- 565-582
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- PMC
- PMC7440877
- OpenAlex
- W3057302762
- Cited by
- 2,001
- References
- 203
- Citations by year
- 2026: 262 · 2025: 346 · 2024: 436 · 2023: 324 · 2022: 311 · 2021: 282 · 2020: 38 · 2012: 1
- FWCI
- 39.98
- Type
- journal article
- Language
- en
- Update notices
- erratum (2020-09-05)
- Open access
- bronze
- doi.org
- Locations
- The Lancet (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Universität Zürich
- National Institutes of Health (HL105339, HD057022, DK074970, DK107444, AG059093, HL132825, AG060730, AG057931, AG062333, AG026572, CA174737, NS08779, AG053589, HL114501, HL119380, NS096493)
- U.S. Department of Veterans Affairs (BX003725, CX001532)
- VetenskapsrÃ¥det (2019–01059)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Social Sciences › Gender Studies › Diversity and Career in Medicine
- Social Sciences › Sociology and Political Science › Gender, Health, and Social Inequality
- Keywords
- sex differences, gender differences, sex as a biological variable, sex hormones, epigenetics, biological sex, gender construction, precision medicine, women's health, men's health, disease susceptibility, treatment response
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Acute Disease, Cause of Death, Chronic Disease, Female, Health Status, Humans, Male, Pneumonia, Viral, Sex Characteristics, Sex Factors, Sex Distribution, Coronavirus Infections, Precision Medicine, Pandemics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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