Rhomboidal Pt (II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy

Near-infrared fluorophores for biomedical imaging

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The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs

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Recent Developments in the Preparation and Chemistry of Metallacycles and Metallacages via Coordination

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A small-molecule dye for NIR-II imaging

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The development of anticancer ruthenium( ii ) complexes: from single molecule compounds to nanomaterials

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Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics

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Stimuli-Responsive Metal–Ligand Assemblies

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Molecular imaging in drug discovery and development

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Lifetime-engineered NIR-II nanoparticles unlock multiplexed in vivo imaging

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Next-generation in vivo optical imaging with short-wave infrared quantum dots

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Photoacoustic imaging-guided chemo-photothermal combinational therapy based on emissive Pt(II) metallacycle-loaded biomimic melanin dots

Li, C., Jia, P., Xu, Y., Ding, F., Yang, W., Sun, Y., Li, X., Yin, G., Xu, L. S., & Yang, G. (2020) · Science China Chemistry · doi:10.1007/s11426-020-9856-7 · Cited by 26

Recent advances in luminescent metallacycles/metallacages for biomedical imaging and cancer therapy

Pang, Y., Li, C., Deng, H., & Sun, Y. (2022) · Dalton Transactions · doi:10.1039/d2dt02766f · Cited by 26

Recent advances in activatable NIR-II organic fluorophores for biomedical applications

Xu, Y., Zhang, P., Gao, A., Xu, R., Wang, Z., Shen, Q., Zhao, Z., Meng, L., & Dang, D. (2022) · Materials Chemistry Frontiers · doi:10.1039/d2qm01120d · Cited by 28

Unlocking the power of optical imaging in the second biological window: Structuring near‐infrared II materials from organic molecules to nanoparticles

Dahal, D., Ray, P., & Pan, D. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1734 · Cited by 28

Ultrasound mediated efficient synthesis of new 4-oxoquinazolin-3(4H)-yl)furan-2-carboxamides as potent tyrosinase inhibitors: Mechanistic approach through chemoinformatics and molecular docking studies

Dige, N. C., Mahajan, P. G., Raza, H., Hassan, M., Vanjare, B. D., Hong, H., Lee, K. H., Latip, J., & Seo, S.-Y. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.103201 · Cited by 26

Design of a Metallacycle‐Based Supramolecular Photosensitizer for In Vivo Image‐Guided Photodynamic Inactivation of Bacteria

Xu, Y., Tuo, W., Yang, L., Sun, Y., Li, C., Chen, X., Yang, W., Yang, G., Stang, P. J., & Sun, Y. (2021) · Angewandte Chemie · doi:10.1002/ange.202110048 · Cited by 24

Thiophene-containing tetraphenylethene derivatives with different aggregation-induced emission (AIE) and mechanofluorochromic characteristics

Yin, Y., Chen, Z., Yang, Y., Liu, G., Fan, C., & Pu, S. (2019) · RSC Advances · doi:10.1039/c9ra04611a · Cited by 24

Molecular imaging of extracellular matrix proteins with targeted probes using magnetic resonance imaging

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Fluorescent Metallacycle‐Cored Amphiphilic Nanoparticles Formed by β‐Cyclodextrin‐Based Host–Guest Interactions towards Cancer Theranostics

Ma, L., Yang, T., Li, S., Zhang, Z., Lu, S., Jeyakkumar, P., Song, Z., Li, X., Yu, G., Chu, D., et al. (2020) · Chemistry - A European Journal · doi:10.1002/chem.202001483 · Cited by 23

2,1,3-Benzothiadiazoles Are Versatile Fluorophore Building Blocks for the Design of Analyte-Sensing Optical Devices

Dias, G. G., Souto, F. T., & Machado, V. G. (2024) · Chemosensors · doi:10.3390/chemosensors12080156 · Cited by 22

Acid-induced tunable white light emission based on triphenylamine derivatives

Liu, X., Qin, Y., Zhu, J., Zhao, X., Cheng, T., Jiang, Y., Sun, H., & Xu, L. S. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.10.012 · Cited by 22

Efficient and Stable NIR‐II Phosphorescence of Metallophilic Molecular Oligomers for In Vivo Single‐Cell Tracking and Time‐Resolved Imaging

Shi, B., Zhang, L., Yan, K., Ming, J., Chen, Z., Chen, Y., He, H., Zhang, H., Wang, L., Wang, S., et al. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202410118 · Cited by 21

Double-channel based fluorescent probe for differentiating GSH and H2Sn (n>1) via a single-wavelength excitation with long-wavelength emission

Rong, Y., Niu, P., Liu, X., Chen, W., Wei, L., & Song, X. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.130224 · Cited by 21

The Applications of Metallacycles and Metallacages

Yin, C., Du, J., Olenyuk, B. Z., Stang, P. J., & Sun, Y. (2023) · Inorganics · doi:10.3390/inorganics11020054 · Cited by 21

Polyvalent Aptamer-Functionalized NIR-II Quantum Dots for Targeted Theranostics in High PD-L1-Expressing Tumors

Huang, X., Zhu, J., Dong, C., Li, Y., Yu, Q. L., Wang, X., Chen, Z., Li, J., Yang, Y. P., & Wang, H. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c01486 · Cited by 21

NIR-II Dye-Labeled Cylindrical Polymer Brushes for in Vivo Imaging

Zhang, L., Zhang, Z., Liu, C., Zhang, X., Fan, Q., Wu, W., & Jiang, X. (2019) · ACS Macro Letters · doi:10.1021/acsmacrolett.9b00815 · Cited by 21

Anthracene-induced formation of highly twisted metallacycle and its crystal structure and tunable assembly behaviors

Chen, C., Sun, Y., Zhao, Y. C., VanderLinden, R. T., Tuo, W., Zhang, F., Zhang, S., Sepehrpour, H., Yan, C., Wang, J., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102602118 · Cited by 21

H2O2-activated NIR fluorescent probe with tumor targeting for cell imaging and fluorescent-guided surgery

Zhong, D., Xiong, S., Zhang, Y., Cui, M., Liu, L., Xu, Y., Wang, P., & Zhang, W. (2024) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2024.136249 · Cited by 20

Molecular fluorophore dimerization: a new paradigm for precision phototheranostics

Bian, H., Ma, D., Chen, Y., Hong, J., Nan, Y., Xu, H., Kim, M. H., Chen, X., Peng, X., & Yoon, J. (2026) · Chemical Society Reviews · doi:10.1039/d5cs01306b · Cited by 21

A new generation of multifunctional therapeutic platforms: Coordination-driven self-assembled metallacycles

Wu, G., Dou, W., Zheng, F., & Yang, H. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.216107 · Cited by 21

Polymeric Systems Containing Supramolecular Coordination Complexes for Drug Delivery

Chen, F., Li, Y., Lin, X., Qiu, H., & Yin, S. (2021) · Polymers · doi:10.3390/polym13030370 · Cited by 19

Active targeted photodynamic therapeutic effect of silver-based nanohybrids on melanoma cancer cells

Montaseri, H., Nkune, N. W., & Abrahamse, H. (2022) · Journal of Photochemistry and Photobiology · doi:10.1016/j.jpap.2022.100136 · Cited by 19

A New Class of NIR‐II Gold Nanocluster‐Based Protein Biolabels for In Vivo Tumor‐Targeted Imaging

Song, X., Zhu, W., Ge, X., Li, R., Li, S., Chen, X., Song, J., Xie, J., Chen, X., & Yang, H. (2020) · Angewandte Chemie · doi:10.1002/ange.202010870 · Cited by 18

Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects

Jangili, P., Won, M., Kim, S. J., Chun, J., Shim, I., Kang, C., Ren, W. X., & Kim, J. S. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00418 · Cited by 18

Recent advances on the construction of long-wavelength emissive supramolecular coordination complexes for photo-diagnosis and therapy

Zhang, Z., Ye, H., Cai, F., & Sun, Y. (2023) · Dalton Transactions · doi:10.1039/d3dt01893h · Cited by 17

Enhanced two-photon absorption of sandwich-like coordination complexes based on squaraine and metallomacrocycle derivatives

Zang, J., Feng, W. Y., Chang, X., Liu, K., Peng, H., Ding, L., Liu, T., & Fang, Y. (2021) · Dyes and Pigments · doi:10.1016/j.dyepig.2021.109487 · Cited by 17

Water-soluble single molecular probe for simultaneous detection of viscosity and hydrazine

Jin, Y., Sun, R.-T., Li, G., Yuan, M., Shao, W., Cao, M., Yuan, C., & Wang, S. (2023) · Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy · doi:10.1016/j.saa.2023.122558 · Cited by 17

Near-infrared probes for luminescence lifetime imaging

Li, B., Lin, J., Huang, P., & Chen, X. S. (2021) · Nanotheranostics · doi:10.7150/ntno.63124 · Cited by 16

Amphiphilic Rhomboidal Organoplatinum(II) Metallacycles with Encapsulated Doxorubicin for Synergistic Cancer Therapy

Li, Y., Yuan, X., Yu, J., Fan, Y., He, T., Lu, S., Li, X., Qiu, H., & Yin, S. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c01163 · Cited by 15

Synthesis of strong electron donating-accepting type organic fluorophore and its polypeptide nanoparticles for NIR-II phototheranostics

Teng, C., Zhang, S., Tian, Y., Cheng, Q., Dang, H., Yin, D., & Yan, L. (2022) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2022.102574 · Cited by 14

Characterization Of Blood–Brain Barrier Crossing And Tumor Homing Peptides By Molecular Dynamics Simulations

Arcangeli, C., Lico, C., Baschieri, S., & Mancuso, M. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s225793 · Cited by 14

A Simple Strategy to Fabricate Phthalocyanine-Encapsulated Nanodots for Magnetic Resonance Imaging and Antitumor Phototherapy

Wu, F., Chen, J., Yue, L., Li, H., Wang, H., & Zhu, X. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00325 · Cited by 14

Pillararene-based AIE-active metallacycle for efficient eradication of antibiotic-resistant bacteria

Jeyakkumar, P., Du, K., Zhang, R., Tian, X., Liu, Q., Jiao, J., Jiang, H., Yu, X., & Hu, X. (2025) · Science China Chemistry · doi:10.1007/s11426-025-2890-2 · Cited by 13

Recent Advances on Pt-Based Compounds for Theranostic Applications

Ferrari, G., Lopez-Martinez, I., Wanek, T., Kuntner, C., & Montagner, D. (2024) · Molecules · doi:10.3390/molecules29153453 · Cited by 13

Acid-Triggered Degradation of Three-In-One Ag 2 S Quantum Dots for In Situ Ratiometric NIR-II Fluorescence Imaging-Guided Ion/Gas Combination Therapy

Tang, X., Zhou, Z., Zhou, L.-Y., Huang, Y., Zhang, L., Zhao, S., & Hu, S. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c00619 · Cited by 12

3-Aryl-2-(thiazol-2-yl)acrylonitriles assembled with aryl/hetaryl rings: Design of the optical properties and application prospects

Eltyshev, A. K., Dzhumaniyazov, T. H., Suntsova, P. O., Минин, А. С., Pozdina, V. A., Dehaen, W., Benassi, E., & Belskaya, N. P. (2020) · Dyes and Pigments · doi:10.1016/j.dyepig.2020.108836 · Cited by 12

Self-assembled metal-based photosensitizers for photodynamic therapy: Mechanisms, applications, and future perspectives

Zhang, J., CHEN, Z. ‐., Shi, P., Xu, G., & Zhao, J. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.217320 · Cited by 12

A selenium-based NIR-II photosensitizer for a highly effective and safe phototherapy plan

Zhang, X., Li, C., Guan, X., Chen, Y., Zhou, Q., Feng, H., Deng, Y. L., Fu, C., Deng, G., Li, J., et al. (2023) · The Analyst · doi:10.1039/d3an01599h · Cited by 12

Dihydroxanthene-based monoamine oxidase A-activated photosensitizers for photodynamic/photothermal therapy of tumors

Mo, Q., Zhong, T., Cao, B., Han, Z., Hu, X., Zhao, S., Wei, X., Yang, Z., & Qin, J. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116474 · Cited by 11

Full-Color-Tunable Nanohydrogels as High-Stability Intracellular Nanothermometers

Wang, Z., Miao, Y., Ou, Q., Niu, R.-X., Jiang, Y., & Zhang, C. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c18201 · Cited by 11

Molecular Theranostic Agent with Programmed Activation for Hypoxic Tumors

Koo, S., Bobba, K. N., Cho, M. Y., Park, H. S., Won, M., Velusamy, N., Hong, K. S., Bhuniya, S., & Kim, J. S. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00722 · Cited by 11

Structural modification of NIR-II fluorophores for angiography beyond 1300 nm: Expanding the xanthene universe

Zhang, C., An, J., Wu, J., Liu, W., Rha, H., Kim, J. S., & Wang, P. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114701 · Cited by 11

Recent advances in combatting bacterial infections via well-designed metallacycles/metallacages

Li, Q., Ye, H., Zhao, F., Li, Y., Zhang, Z., Yan, Q., & Sun, Y. (2023) · Dalton Transactions · doi:10.1039/d3dt03966h · Cited by 10

Construction of eco-biosensor and its potential application for highly selective, sensitive and fast detection of viscumin

Nasirahmadi, S., Akbari‐adergani, B., & Shoeibi, S. (2020) · Analytica Chimica Acta · doi:10.1016/j.aca.2020.02.035 · Cited by 9

Pt( ii ) metallacycles encapsulated by ferritin enable precise cancer combination chemo-photodynamic therapy

Min, X., Li, M., Zhang, W., Li, R., Zhang, Z., Wang, P., Su, W., Li, F., Sun, Y. M., & Liu, Y. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb02349k · Cited by 9

Supramolecular coordination complexes (SCCs) with aggregation-induced emission for in vitro photodynamic therapy

Jia, H., Shi, T., He, T., Li, Y., & Yin, S. (2023) · Dalton Transactions · doi:10.1039/d2dt03855b · Cited by 9

Aggregation-induced emission (AIE)-active metallacycles with near-infrared emission for photodynamic therapy

Shen, Q., Gao, K. S., Zhao, Z., Gao, A., Xu, Y., Wang, H., Meng, L., Zhang, M., & Dang, D. (2023) · Chemical Communications · doi:10.1039/d3cc04166b · Cited by 7

Efficient and Stable NIR‐II Phosphorescence of Metallophilic Molecular Oligomers for In Vivo Single‐Cell Tracking and Time‐Resolved Imaging

Shi, B., Zhang, L., Yan, K., Ming, J., Chen, Z., Chen, Y., He, H., Zhang, H., Wang, L., Wang, S., et al. (2024) · Angewandte Chemie · doi:10.1002/ange.202410118 · Cited by 7

A quinolone derivative-based organoplatinum(II) metallacycle supramolecular self-delivery nanocarrier for combined cancer therapy

Chen, W., He, J. W., Li, H., Li, X., & Tian, W. J. (2020) · Supramolecular chemistry · doi:10.1080/10610278.2020.1846739 · Cited by 7

Ratiometric MRI probes for tumor microenvironment profiling: Design principles, multimodal validation, and future perspectives in precision oncology

Hu, J., Wang, C., Yao, D., & Wang, D. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216709 · Cited by 5

Topical progress in medicinal applications of self‐assembled organoplatinum complexes using diverse Pt(II)‐ and N‐based tectons

Kumar, S., Jana, A., Bhowmick, S., & Das, N. (2022) · Applied Organometallic Chemistry · doi:10.1002/aoc.6722 · Cited by 5

An unexpected Griess reaction on the important anti-malarial drug primaquine and its application for drug determination

Deng, T., Wu, S., Wu, Y., Hu, S., Bao, H., Huang, X., Xu, Q., Yang, Z., Song, J., & Liu, F. (2019) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2019.03.063 · Cited by 5

Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles

Huang, C., Guan, X., Lin, H. P., Liang, L., Miao, Y., Wu, Y., Bao, H., Wu, X., Shen, A., Wei, M., et al. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.762956 · Cited by 5

Colour/luminescence changes of transition metal complexes induced by gaseous small molecules for monitoring reaction progress and environmental changes

Shinozaki, K. (2024) · Dalton Transactions · doi:10.1039/d4dt01822b · Cited by 4

Self-assembled discrete coordination architectures toward biological applications

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Giant excitonic upconverted emission of two-dimensional semiconductor in doubly resonant plasmonic nanocavityPreprint

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Architecting NIR-II metal supramolecular dyes—illuminating the path to precision medicine

Zhao, F., Song, Q., Qiu, P., Xiong, X., Tang, Y., & Sun, Y. (2026) · Chemical Science · doi:10.1039/d6sc00523c · Cited by 2

Configuration and Molecular Flexibility Regulated Reactive Oxygen Species Type and Efficiency for Potent Anticancer Performance: A BODIPY-Pt(II) Complex Case

Chong, H., Zhong, G., Sun, X., Yang, X., Chang, C., Zhang, H., Zhu, S.-E., Yang, Z., Zhou, G., Wang, T., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c01455 · Cited by 1

Near-Infrared II Optical Imaging

He, S., & Cheng, Z. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-816386-3.00025-9 · Cited by 1

Organic Dyes for NIR Imaging

Kamimura, M. (2020) · Springer eBooks · doi:10.1007/978-981-15-9627-8_3

Recent progress in supramolecular coordination complexes for bacterial diagnosis and treatment

Song, Q., Zhang, J., Yan, L., Zhang, Z., Li, J., Liu, W., & Sun, Y. (2026) · Dalton Transactions · doi:10.1039/d5dt02682b

Innovative self-assembling dendrimer nanosystems for bioimaging

Ding, L. (2020) · doi:10.70675/0543b196z267fz494fz8631z419dc2f01122

Polymeric Nanomedicines for Comprehensive Regulation of Tumor Microenvironment

Li, H., Wu, R.-Y., Mao, X.-T., Zhou, X.-R., Hao, K., & Tian, H.-Y. (2026) · Chinese Journal of Polymer Science · doi:10.1007/s10118-026-3678-6

Triphenylamine-Based Supramolecular Coordination Metallacycles

Ai, K., Bu, Z., Hu, Y., & Li, S. (2026) · Molecules · doi:10.3390/molecules31152652

Self-assembled Near-Infrared Metallacycles and Metallacages for Cancer Theranostics

Dong, Y., Wang, W., Liu, W., Zhu, X., Chen, J., & Zhou, J. (2026) · 化学学报 · doi:10.6023/a26030068

A nano-cocktail of an NIR-II emissive fluorophore and organoplatinum( ii ) metallacycle for efficient cancer imaging and therapy

Ding, F., Chen, Z., Kim, W. Y., Sharma, A. K., Li, C., Ouyang, Q., Zhu, H., Yang, G., Sun, Y., & Kim, J. S. (2019) · Chemical Science · doi:10.1039/c9sc02466b · Cited by 113

Building multipurpose nano-toolkit by rationally decorating NIR-II fluorophore to meet the needs of tumor diagnosis and treatment

Cui, C., Li, J., Fang, J. Y., Zhao, Y., Zhang, Y., Ye, S., Wang, A., Feng, Y., Mao, Q., Qin, H., et al. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.03.023 · Cited by 28

Novel Pt(IV) Prodrug with Long-Wavelength Absorption in the NIR Range

Spector, D. V., Zharova, A., Bykusov, V., Akasov, R., Stepanov, M., Kuzmin, V. A., Egorov, A. E., Burtsev, I. D., Beloglazkina, E. K., & Krasnovskaya, O. O. (2025) · Russian Journal of General Chemistry · doi:10.1134/s1070363225607744 · Cited by 1

NIR‐II Emissive Ru(II) Metallacycle Assisting Fluorescence Imaging and Cancer Therapy

Fan, Y., Li, C., Bai, S., Ma, X., Yang, J., Guan, X., & Sun, Y. (2022) · Small · doi:10.1002/smll.202201625 · Cited by 51

Theranostic Colloidal Nanoparticles of Pyrrolopyrrole Cyanine Derivatives for Simultaneous Near-Infrared Fluorescence Cancer Imaging and Photothermal Therapy

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