Cited by 165Nanoplatforms for cancer theranosticsMolecular Sensors and Ion DetectionMetal complexes synthesis and properties

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Rhomboidal Pt (II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy

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Sun, Yue, Ding, Feng, Zhou, Zhixuan, Li, Chonglu, Pu, Maoping, Xu, Yuling, Zhan, Yibei, Lu, Xiaoju, Li, Haibing, Yang, Guangfu, Sun, Yao, Stang, Peter J.·2019·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1817021116PMC PMC6369813

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Abstract

Significance The biomedical applications of fluorescent anticancer agents in the first near-IR region (NIR-I) have been hampered by problems of photostability, autofluorescence, and limited penetration depth in biological tissues. To shift the fluorescence theranostic region from the NIR-I to the longer-wavelength region for accurate cancer diagnosis and treatment, Pt(II) metallacycle-based fluorescent nanoprobe 1 with fluorescence emission in the NIR-II region is designed. In vitro and in vivo studies demonstrate that 1 has good photostability and the ability to efficiently inhibit the growth of tumor with minimal side effects. It also improves the fluorescent imaging quality and signal-to-noise ratio for cancer theranostics. This study provides an opportunity for further design of NIR-II theranostic anticancer agents for future biomedical applications.

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Authors: Sun, Y., Ding, F., Zhou, Z., Li, C., Pu, M., Xu, Y., Zhan, Y., Lu, X., Li, H., Yang, G., Sun, Y., & Stang, P. J.
Affiliations: University of Utah (US)
Central China Normal University (CN)
RWTH Aachen University (DE)
Hubei Polytechnic University (CN)
Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 430079 Wuhan, China;
ORCID: Sun, Yue
Zhou, Zhixuan
Li, Chonglu
Pu, Maoping
Xu, Yuling
Zhan, Yibei
Lu, Xiaoju
Li, Haibing
Sun, Yao
Stang, Peter J.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2019-01-22
Volume: 116
Issue: 6
Pages: 1968-1973
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1817021116
PMC: PMC6369813
OpenAlex: W2911761965
Cited by: 165
References: 38
Citations by year: 2026: 7 · 2025: 4 · 2024: 16 · 2023: 16 · 2022: 20 · 2021: 33 · 2020: 39 · 2019: 30
FWCI: 10.75
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.pnas.org/site/aboutpnas/licenses.xhtml (vor, 181 d)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01CA215157)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
Keywords: NIR-II fluorescence, theranostic nanoprobes, cancer diagnosis, image-guided therapy, photostability, anticancer agents, tumor growth inhibition, fluorescence imaging
MeSH terms: Theranostic Nanomedicine, Animals, Magnetic Resonance Imaging, Mice, Inbred C57BL, Neoplasms, Neoplasms, Experimental, Photons, Mice, Signal-To-Noise Ratio

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Rhomboidal Pt (II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy

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