Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics

Near-infrared fluorophores for biomedical imaging

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A small-molecule dye for NIR-II imaging

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A Two-Dimensional Biodegradable Niobium Carbide (MXene) for Photothermal Tumor Eradication in NIR-I and NIR-II Biowindows

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A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice

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Through-skull fluorescence imaging of the brain in a new near-infrared window

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Multifunctional in vivo vascular imaging using near-infrared II fluorescence

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Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window

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Correction: Corrigendum: Endogenous fructose production and metabolism in the liver contributes to the development of metabolic syndrome

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Rare-earth-doped biological composites as in vivo shortwave infrared reporters

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Exploiting the biological windows: current perspectives on fluorescent bioprobes emitting above 1000 nm

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Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green

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Surface Plasmon Resonance Enhanced Light Absorption and Photothermal Therapy in the Second Near-Infrared Window

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A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging

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Ultrafast fluorescence imaging in vivo with conjugated polymer fluorophores in the second near-infrared window

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In vivo real-time visualization of tissue blood flow and angiogenesis using Ag2S quantum dots in the NIR-II window

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Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm

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Size-Dependent Ag 2 S Nanodots for Second Near-Infrared Fluorescence/Photoacoustics Imaging and Simultaneous Photothermal Therapy

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In Vivo Fluorescence Imaging in the Second Near-Infrared Window with Long Circulating Carbon Nanotubes Capable of Ultrahigh Tumor Uptake

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Traumatic Brain Injury Imaging in the Second Near‐Infrared Window with a Molecular Fluorophore

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Tunable Narrow Band Emissions from Dye-Sensitized Core/Shell/Shell Nanocrystals in the Second Near-Infrared Biological Window

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In vivo biosensing via tissue-localizable near-infrared-fluorescent single-walled carbon nanotubes

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Designing Multi‐Branched Gold Nanoechinus for NIR Light Activated Dual Modal Photodynamic and Photothermal Therapy in the Second Biological Window

Vijayaraghavan, P., Liu, C., Vankayala, R., Chiang, C., & Hwang, K. C. (2014) · Advanced Materials · doi:10.1002/adma.201400703 · Cited by 372 · see citing works

Biological Imaging Using Nanoparticles of Small Organic Molecules with Fluorescence Emission at Wavelengths Longer than 1000 nm

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Novel benzo-bis(1,2,5-thiadiazole) fluorophores for in vivo NIR-II imaging of cancer

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Molecular imaging of biological systems with a clickable dye in the broad 800- to 1,700-nm near-infrared window

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Multimodal Biomedical Imaging with Asymmetric Single-Walled Carbon Nanotube/Iron Oxide Nanoparticle Complexes

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Highly Efficient NIR-II Photothermal Conversion Based on an Organic Conjugated Polymer

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Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery

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Deep, noninvasive imaging and surgical guidance of submillimeter tumors using targeted M13-stabilized single-walled carbon nanotubes

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In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers

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Biological Imaging Using Nanoparticles of Small Organic Molecules with Fluorescence Emission at Wavelengths Longer than 1000 nm

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Industrial-scale separation of high-purity single-chirality single-wall carbon nanotubes for biological imaging

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Indocyanine green fluorescence in second near-infrared (NIR-II) window

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Tunable Ultrasmall Visible-to-Extended Near-Infrared Emitting Silver Sulfide Quantum Dots for Integrin-Targeted Cancer Imaging

Tang, R., Xue, J., Xu, B. J., Shen, D., Sudlow, G. P., & Achilefu, S. A. (2015) · ACS Nano · doi:10.1021/nn5071183 · Cited by 217 · see citing works

Tracking of Transplanted Human Mesenchymal Stem Cells in Living Mice using Near‐Infrared Ag2S Quantum Dots

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Multifunctional Biomedical Imaging in Physiological and Pathological Conditions Using a NIR‐II Probe

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Hybrid Nanostructures for High‐Sensitivity Luminescence Nanothermometry in the Second Biological Window

Navarro‐Cerón, E., Ortgies, D. H., del Rosal, B., Ren, F., Benayas, A., Vetrone, F., Ma, D., Sanz-Rodrı́guez, F., García‐Solé, J., Jaque, D., et al. (2015) · Advanced Materials · doi:10.1002/adma.201501014 · Cited by 200 · see citing works

Biodegradable MoO x nanoparticles with efficient near-infrared photothermal and photodynamic synergetic cancer therapy at the second biological window

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Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery

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Synthesis, Characterization, and Biomedical Applications of a Targeted Dual-Modal Near-Infrared-II Fluorescence and Photoacoustic Imaging Nanoprobe

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Preoperative Detection and Intraoperative Visualization of Brain Tumors for More Precise Surgery: A New Dual-Modality MRI and NIR Nanoprobe

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X-ray-Induced Shortwave Infrared Biomedical Imaging Using Rare-Earth Nanoprobes

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In Vivo Fluorescence Imaging with Ag2S Quantum Dots in the Second Near‐Infrared Region

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Real-time in vivo visualization of tumor therapy by a near-infrared-II Ag2S quantum dot-based theranostic nanoplatform

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Live imaging of follicle stimulating hormone receptors in gonads and bones using near infrared II fluorophore

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Near-infrared (1550 nm) in vivo bioimaging based on rare-earth doped ceramic nanophosphors modified with PEG-b-poly(4-vinylbenzylphosphonate)

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Copper Manganese Sulfide Nanoplates: A New Two-Dimensional Theranostic Nanoplatform for MRI/MSOT Dual-Modal Imaging-Guided Photothermal Therapy in the Second Near-Infrared Window

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Dynamically tuning near-infrared-induced photothermal performances of TiO 2 nanocrystals by Nb doping for imaging-guided photothermal therapy of tumors

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A novel photoacoustic nanoprobe of ICG@PEG-Ag 2 S for atherosclerosis targeting and imaging in vivo

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CXCR‐4 Targeted, Short Wave Infrared (SWIR) Emitting Nanoprobes for Enhanced Deep Tissue Imaging and Micrometastatic Cancer Lesion Detection

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Size and Shell Effects on the Photoacoustic and Luminescence Properties of Dual Modal Rare-Earth-Doped Nanoparticles for Infrared Photoacoustic Imaging

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First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows

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Stable, Wavelength‐Tunable Fluorescent Dyes in the NIR‐II Region for In Vivo High‐Contrast Bioimaging and Multiplexed Biosensing

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Gathering brings strength: How organic aggregates boost disease phototheranostics

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Planar and Twisted Molecular Structure Leads to the High Brightness of Semiconducting Polymer Nanoparticles for NIR-IIa Fluorescence Imaging

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Multiplexed NIR‐II Probes for Lymph Node‐Invaded Cancer Detection and Imaging‐Guided Surgery

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NIR-II bioimaging of small organic molecule

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Bright and Stable NIR‐II J‐Aggregated AIE Dibodipy‐Based Fluorescent Probe for Dynamic In Vivo Bioimaging

Zhang, Q., Yu, P., Fan, Y., Sun, C., He, H., Liu, X., Lu, L., Zhao, M., Zhang, H., & Zhang, F. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202012427 · Cited by 216 · see citing works

Polymethine Thiopyrylium Fluorophores with Absorption beyond 1000 nm for Biological Imaging in the Second Near-Infrared Subwindow

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ROS/RNS and Base Dual Activatable Merocyanine‐Based NIR‐II Fluorescent Molecular Probe for in vivo Biosensing

Zhang, X., Chen, Y., He, H., Wang, S., Lei, Z., & Zhang, F. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202109728 · Cited by 176 · see citing works

Rhomboidal Pt (II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy

Sun, Y., Ding, F., Zhou, Z., Li, C., Pu, M., Xu, Y., Zhan, Y., Lu, X., Li, H., Yang, G., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817021116 · Cited by 165 · see citing works

The in vivo fate of polymeric micelles

Cai, Y., Qi, J., Lu, Y., He, H., & Wu, W. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114463 · Cited by 154 · see citing works

Long wavelength–emissive Ru(II) metallacycle–based photosensitizer assisting in vivo bacterial diagnosis and antibacterial treatment

Xu, Y., Li, C., Ma, X., Tuo, W., Tu, L., Li, X., Sun, Y., Stang, P. J., & Sun, Y. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2209904119 · Cited by 156 · see citing works

Polymethine‐Based Semiconducting Polymer Dots with Narrow‐Band Emission and Absorption/Emission Maxima at NIR‐II for Bioimaging

Liu, M., Zhang, Z., Yang, Y., & Chan, Y. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202011914 · Cited by 134 · see citing works

Molecular engineering of AIE luminogens for NIR-II/IIb bioimaging and surgical navigation of lymph nodes

Song, S., Wang, Y., Zhao, Y., Huang, W., Zhang, F., Zhu, S., Wu, Q., Fu, S., Tang, B. Z., & Wang, D. (2022) · Matter · doi:10.1016/j.matt.2022.06.030 · Cited by 133 · see citing works

Benzobisthiadiazole-Based Small Molecular Near-Infrared-II Fluorophores: From Molecular Engineering to Nanophototheranostics

Wang, L., Li, N., Wang, W., Mei, A., Shao, J., Wang, W., & Dong, X. (2024) · ACS Nano · doi:10.1021/acsnano.3c12316 · Cited by 127 · see citing works

Recent advances in the design and applications of near-infrared II responsive small molecule phototherapeutic agents

Ma, D., Bian, H., Gu, M., Wang, L., Chen, X., & Peng, X. (2024) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2024.215677 · Cited by 124 · see citing works

Molecular Engineering of an Organic NIR‐II Fluorophore with Aggregation‐Induced Emission Characteristics for In Vivo Imaging

Wu, W., Yang, Y., Yang, Y., Yang, Y., Zhang, K., Guo, L., Ge, H., Chen, X., Liu, J., & Feng, H. (2019) · Small · doi:10.1002/smll.201805549 · Cited by 122 · see citing works

Increasing Molecular Planarity through Donor/Side‐Chain Engineering for Improved NIR‐IIa Fluorescence Imaging and NIR‐II Photothermal Therapy under 1064 nm

Chen, S., Pan, Y., Chen, K., Chen, P., Shen, Q., Sun, P., Hu, W., & Fan, Q. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202215372 · Cited by 122 · see citing works

NIR‐II Organic Nanotheranostics for Precision Oncotherapy

Dai, H., Wang, X., Shao, J., Wang, W., Mou, X., & Dong, X. (2021) · Small · doi:10.1002/smll.202102646 · Cited by 110 · see citing works

Bright, Magnetic NIR-II Quantum Dot Probe for Sensitive Dual-Modality Imaging and Intensive Combination Therapy of Cancer

Li, Y., Zhang, P., Tang, W., McHugh, K. J., Kershaw, S. V., Jiao, M., Huang, X., Kalytchuk, S., Perkinson, C. F., Yue, S., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c01153 · Cited by 98 · see citing works

Bio-Erasable Intermolecular Donor–Acceptor Interaction of Organic Semiconducting Nanoprobes for Activatable NIR-II Fluorescence Imaging

Tang, Y., Li, Y., Lu, X., Hu, X., Zhao, H., Hu, W., Lu, F., Fan, Q., & Huang, W. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201807376 · Cited by 96 · see citing works

Enlarging the Reservoir: High Absorption Coefficient Dyes Enable Synergetic Near Infrared‐II Fluorescence Imaging and Near Infrared‐I Photothermal Therapy

Li, Y., Zhang, J., Liu, S., Zhang, C., Chuah, C., Tang, Y., Kwok, R. T. K., Lam, J. W. Y., Ou, H., Ding, D., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202102213 · Cited by 88 · see citing works

Long-term monitoring of intravital biological processes using fluorescent protein-assisted NIR-II imaging

Chen, M., Feng, Z., Fan, X., Sun, J., Geng, W., Wu, T., Sheng, J., Qian, J., & Xu, Z. (2022) · Nature Communications · doi:10.1038/s41467-022-34274-w · Cited by 57 · see citing works

“Dual‐Key‐and‐Lock” NIR‐II NSCyanines Enable High‐Contrast Activatable Phototheranostics in Extrahepatic Diseases

Tian, Y., Chen, Z., Liu, S., Wu, F., Cao, W., Pang, D., & Xiong, H. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202309768 · Cited by 57 · see citing works

NIR-II bioimaging of small molecule fluorophores: From basic research to clinical applications

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Rigidity Bridging Flexibility to Harmonize Three Excited‐State Deactivation Pathways for NIR‐II‐Fluorescent‐Imaging‐Guided Phototherapy

Huang, W., Yang, H., Hu, Z., Fan, Y., Guan, X., Feng, W., Liu, Z., & Sun, Y. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101003 · Cited by 40 · see citing works

Improved Fluorescence and Brightness of Near-Infrared and Shortwave Infrared Emitting Polymer Dots for Bioimaging Applications

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New conjugated polymer nanoparticles with high photoluminescence quantum yields for far-red and near infrared fluorescence bioimaging

Koralli, P., D. Nega, A., Vagiaki, L. E., Pavlou, A., Siskos, M. G., Dimitrakopoulou-Strauss, A., Gregoriou, V. G., & Chochos, C. L. (2020) · Materials Chemistry Frontiers · doi:10.1039/d0qm00195c · Cited by 37 · see citing works

Donor–Acceptor–Donor Near-Infrared-II Aggregation-Induced Emission Luminogens (AIEgens) Encapsulated within Nanometer-Sized Exosomes for Tumor Imaging

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