Next-generation in vivo optical imaging with short-wave infrared quantum dots
Open accessAbstract
For in vivo imaging, the short-wavelength infrared region (SWIR; 1000-2000 nm) provides several advantages over the visible and near-infrared regions: general lack of autofluorescence, low light absorption by blood and tissue, and reduced scattering. However, the lack of versatile and functional SWIR emitters has prevented the general adoption of SWIR imaging by the biomedical research community. Here, we introduce a class of high-quality SWIR-emissive indium-arsenide-based quantum dots (QDs) that are readily modifiable for various functional imaging applications, and that exhibit narrow and size-tunable emission and a dramatically higher emission quantum yield than previously described SWIR probes. To demonstrate the unprecedented combination of deep penetration, high spatial resolution, multicolor imaging and fast-acquisition-speed afforded by the SWIR QDs, we quantified, in mice, the metabolic turnover rates of lipoproteins in several organs simultaneously and in real time as well as heartbeat and breathing rates in awake and unrestrained animals, and generated detailed three-dimensional quantitative flow maps of the mouse brain vasculature.
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In vivo mouse brain vasculature imaging with SWIR emitting indium-arsenide-based quantum dots allowed single-particle image velocimetry with high spatiotemporal resolution.
“In vivo mouse brain vasculature imaging with SWIR emitting indium-arsenide-based quantum dots (QDs) allowed single-particle image velocimetry with high spatiotemporal resolution.206”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [206]
Detailed three-dimensional quantitative flow maps in the mouse brain were demonstrated and allow the study of ischemia-reperfusion in stroke.
“Detailed three-dimensional quantitative flow maps in the mouse brain were demonstrated and allow the study of ischemia–reperfusion in stroke.”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [206]
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Fiji: an open-source platform for biological-image analysis
Schindelin, J., Arganda-Carreras, I., Frise, E., Kaynig, V., Longair, M., Pietzsch, T., Preibisch, S., Rueden, C., Saalfeld, S., Schmid, B., et al. (2012) · Nature Methods · doi:10.1038/nmeth.2019 · Cited by 66,890 · see citing works
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189 · see citing works
Particle-Imaging Techniques for Experimental Fluid Mechanics
Adrian, R. J. (1991) · Annual Review of Fluid Mechanics · doi:10.1146/annurev.fl.23.010191.001401 · Cited by 3,405 · see citing works
In Vivo Imaging of Quantum Dots Encapsulated in Phospholipid Micelles
Dubertret, B., Skourides, P., Norris, D. J., Noireaux, V., Brivanlou, A. H., & Libchaber, A. (2002) · Science · doi:10.1126/science.1077194 · Cited by 3,019 · see citing works
Hines, M. A., & Scholes, G. D. (2003) · Advanced Materials · doi:10.1002/adma.200305395 · Cited by 1,838 · see citing works
Brown adipose tissue activity controls triglyceride clearance
Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Weller, H., Waurisch, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2297 · Cited by 1,608 · see citing works
Self-citationLi, J. J., Wang, Y. A., Guo, W., Keay, J. C., Mıshıma, T. D., Johnson, M. B., & Peng, X. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0363563 · Cited by 1,565 · see citing works
Chen, O., Zhao, J., Chauhan, V. P., Cui, J., Wong, C., Harris, D. K., Wei, H., Han, H., Fukumura, D., Jain, R. K., et al. (2013) · Nature Materials · doi:10.1038/nmat3539 · Cited by 1,432 · see citing works
Self-citationA route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice
Welsher, K., Liu, Z., Sherlock, S. P., Robinson, J. T., Chen, Z., Daranciang, D., & Dai, H. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2009.294 · Cited by 1,287 · see citing works
Twenty years of particle image velocimetry
Adrian, R. J. (2005) · Experiments in Fluids · doi:10.1007/s00348-005-0991-7 · Cited by 1,271 · see citing works
Through-skull fluorescence imaging of the brain in a new near-infrared window
Hong, G., Diao, S., Chang, J., Antaris, A. L., Chen, C., Zhang, B., Zhao, S., Atochin, D. N., Huang, P. L., Andreasson, K. I., et al. (2014) · Nature Photonics · doi:10.1038/nphoton.2014.166 · Cited by 1,052 · see citing works
Multifunctional in vivo vascular imaging using near-infrared II fluorescence
Hong, G., Lee, J. C., Robinson, J. T., Raaz, U., Xie, L., Huang, N. F., Cooke, J. P., & Dai, H. (2012) · Nature Medicine · doi:10.1038/nm.2995 · Cited by 995 · see citing works
Welsher, K., Sherlock, S. P., & Dai, H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014501108 · Cited by 958 · see citing works
Zhang, Y., Hong, G., Zhang, Y., Chen, G., Li, F., Dai, H., & Wang, Q. (2012) · ACS Nano · doi:10.1021/nn301218z · Cited by 765 · see citing works
Rare-earth-doped biological composites as in vivo shortwave infrared reporters
Naczynski, D. J., Tan, M. C., Zevon, M., Wall, B., Kohl, J., Kulesa, A. B., Chen, S., Roth, C. M., Riman, R. E., & Moghe, P. V. (2013) · Nature Communications · doi:10.1038/ncomms3199 · Cited by 757 · see citing works
Hong, G., Zou, Y., Antaris, A. L., Diao, S., Wu, D., Cheng, K., Zhang, X., Chen, C., Liu, B., He, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms5206 · Cited by 563 · see citing works
Selection of Quantum Dot Wavelengths for Biomedical Assays and Imaging
Lim, Y. T., Kim, S., Nakayama, A., Stott, N. E., Bawendi, M. G., & Frangioni, J. V. (2003) · Molecular Imaging · doi:10.1162/153535003765276282 · Cited by 559 · see citing works
Self-citationA PIV Algorithm for Estimating Time-Averaged Velocity Fields
Meinhart, C. D., Wereley, S. T., & Santiago, J. G. (2000) · Journal of Fluids Engineering · doi:10.1115/1.483256 · Cited by 499 · see citing works
Pietryga, J. M., Werder, D. J., Williams, D. J., et al. (2008) · Journal of the American Chemical Society · doi:10.1021/ja710437r · Cited by 478 · see citing works
Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo
Stroh, M., Zimmer, J. P., Duda, D. G., Levchenko, T. S., Cohen, K. S., Brown, E. B., Scadden, D. T., Torchilin, V. P., Bawendi, M. G., Fukumura, D., et al. (2005) · Nature Medicine · doi:10.1038/nm1247 · Cited by 433 · see citing works
Self-citationRetinal receptors in rodents maximally sensitive to ultraviolet light
Jacobs, G. H., Neitz, J., & Deegan, J. F. (1991) · Nature · doi:10.1038/353655a0 · Cited by 415 · see citing works
Kloepper, J., Riedemann, L., Amoozgar, Z., Seano, G., Susek, K., Yu, V., Dalvie, N., Amelung, R. L., Datta, M., Song, J. W., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525360113 · Cited by 357 · see citing works
Self-citationTao, Z., Hong, G., Shinji, C., Chen, C., Diao, S., Antaris, A. L., Zhang, B., Zou, Y., & Dai, H. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201307346 · Cited by 330 · see citing works
Dong, B., Li, C., Chen, G., Zhang, Y., Zhang, Y., Deng, M., & Wang, Q. (2013) · Chemistry of Materials · doi:10.1021/cm400812v · Cited by 300 · see citing works
Franke, D., Harris, D. K., Chen, O., Bruns†, O. T., Carr, J. A., Wilson, M. W. B., & Bawendi, M. G. (2016) · Nature Communications · doi:10.1038/ncomms12749 · Cited by 295 · see citing works
Self-citationA secreted luciferase for ex vivo monitoring of in vivo processes
Wurdinger, T. D., Badr, C. E., Pike, L. S., de Kleine, R. H. J., Weissleder, R., Breakefield, X. O., & Tannous, B. A. (2008) · Nature Methods · doi:10.1038/nmeth.1177 · Cited by 284 · see citing works
Yi, H., Ghosh, D., Ham, M., Qi, J., Barone, P. W., Strano, M. S., & Belcher, A. M. (2012) · Nano Letters · doi:10.1021/nl2031663 · Cited by 276 · see citing works
Biodistribution, pharmacokinetics and toxicology of Ag2S near-infrared quantum dots in mice
Zhang, Y., Zhang, Y., Hong, G., Wei, H., Zhou, K., Yang, K., Li, F., Chen, G., Liu, Z., Dai, H., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.089 · Cited by 254 · see citing works
Self-citationGhosh, D., Bagley, A. F., Na, Y. J., Birrer, M. J., Bhatia, S. N., & Belcher, A. M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400821111 · Cited by 253 · see citing works
Tao, Z., Hong, G., Shinji, C., Chen, C., Diao, S., Antaris, A. L., Zhang, B., Zou, Y., & Dai, H. (2013) · Angewandte Chemie · doi:10.1002/ange.201307346 · Cited by 239 · see citing works
Ag 2 Se Quantum Dots with Tunable Emission in the Second Near-Infrared Window
Zhu, C., Jiang, P., Zhang, Z., Zhu, D., Tian, Z., & Pang, D. (2013) · ACS Applied Materials & Interfaces · doi:10.1021/am303110x · Cited by 231 · see citing works
Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks
Kamoun, W. S., Chae, S., Lacorre, D. A., Tyrrell, J. A., Mitre, M., Gillissen, M. A., Fukumura, D., Jain, R. K., & Munn, L. L. (2010) · Nature Methods · doi:10.1038/nmeth.1475 · Cited by 214 · see citing works
Self-citationAharoni, A., Mokari, T., Popov, I., & Banin, U. (2005) · Journal of the American Chemical Society · doi:10.1021/ja056326v · Cited by 202 · see citing works
Supran, G. J., Song, K. W., Hwang, G. W., et al. (2015) · Advanced Materials · doi:10.1002/adma.201404636 · Cited by 200 · see citing works
Self-citationAll-optical anatomical co-registration for molecular imaging of small animals using dynamic contrast
Hillman, E. M. C., & Moore, A. V. (2007) · Nature Photonics · doi:10.1038/nphoton.2007.146 · Cited by 188 · see citing works
Imaging preclinical tumour models: improving translational power
de Jong, M., Essers, J., & van Weerden, W. M. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3751 · Cited by 176 · see citing works
Bruns†, O. T., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Lauterwasser, J., Nikolić, M. S., Mollwitz†, B., Merkel, M., Bigall, N. C., et al. (2009) · Nature Nanotechnology · doi:10.1038/nnano.2008.405 · Cited by 165 · see citing works
Self-citationKodack, D. P., Chung, E., Yamashita, H., Incio, J., Duyverman, A. M. M. J., Song, Y., Farrar, C. T., Huang, Y., Ager, E., Kamoun, W., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216078109 · Cited by 153 · see citing works
Self-citationBlind Source Separation Techniques for the Decomposition of Multiply Labeled Fluorescence Images
Neher, R. A., Mitkovski, M., Kirchhoff, F., Neher, E., Theis, F. J., & Zeug, A. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2008.10.068 · Cited by 136 · see citing works
Carbon nanotubes as in vivo bacterial probes
Bardhan, N. M., Ghosh, D., & Belcher, A. M. (2014) · Nature Communications · doi:10.1038/ncomms5918 · Cited by 131 · see citing works
Tsukasaki, Y., Morimatsu, M., Nishimura, G., Sakata, T., Yasuda, H., Komatsuzaki, A., Watanabe, T. M., & Jin, T. (2014) · RSC Advances · doi:10.1039/c4ra06098a · Cited by 84 · see citing works
Jung, C., Kaul, M. G., Bruns, O. T., et al. (2013) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.113.000607 · Cited by 49 · see citing works
Self-citationMarxen, M., Sullivan, P. E., Loewen, M., et al. (2000) · Experiments in Fluids · doi:10.1007/s003489900085 · Cited by 44 · see citing works
Tsukasaki, Y., Komatsuzaki, A., Mori, Y., Ma, Q., Yoshioka, Y., & Jin, T. (2014) · Chemical Communications · doi:10.1039/c4cc06542e · Cited by 39 · see citing works
The mouse in biomedical research. Volume III. Normative biology, immunology, and husbandry.
Foster, H. L., Small, J. D., & Fox, J. G. (1983) · Cited by 34 · see citing works
Measurements of turbulence in a microscale multi-inlet vortex nanoprecipitation reactor
Shi, Y., Cheng, J. C., Fox, R. O., et al. (2013) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/23/7/075005 · Cited by 24 · see citing works
Self-citationNanocrystals, a New Tool to Study Lipoprotein Metabolism and Atherosclerosis
Heeren, J., & Bruns, O. T. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112799095293 · Cited by 10 · see citing works
Self-citationNanocrystal Core Lipoprotein Biomimetics for Imaging of Lipoproteins and Associated Diseases
Fay, F., Sánchez-Gaytán, B. L., Cormode, D. P., Skajaa, T., Fisher, E. A. A., Fayad, Z. A., & Mulder, W. J. M. (2012) · Current Cardiovascular Imaging Reports · doi:10.1007/s12410-012-9181-1 · Cited by 7 · see citing works
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Li, C., Chen, G., Zhang, Y., Wu, F., & Wang, Q. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c07022 · Cited by 1,037 · see citing works
Carr, J. A., Franke, D., Caram, J. R., Perkinson, C. F., Saif, M., Askoxylakis, V., Datta, M., Fukumura, D., Jain, R. K., Bawendi, M. G., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718917115 · Cited by 721 · see citing works
Self-citationLi, B., Lu, L., Zhao, M., Lei, Z., & Zhang, F. (2018) · Angewandte Chemie International Edition · doi:10.1002/anie.201801226 · Cited by 658 · see citing works
Sun, C., Li, B., Zhao, M., Wang, S., Lei, Z., Lu, L., Zhang, H., Feng, L., Dou, C., Yin, D., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b10043 · Cited by 582 · see citing works
Zhong, Y., Ma, Z., Wang, F., Wang, X., Yang, Y., Liu, Y., Zhao, X., Li, J., Du, H., Zhang, M., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0262-4 · Cited by 575 · see citing works
In vivo NIR-II fluorescence imaging for biology and medicine
Wang, F., Zhong, Y., Bruns, O., Liang, Y., & Dai, H. (2024) · Nature Photonics · doi:10.1038/s41566-024-01391-5 · Cited by 564 · see citing works
Self-citationAnti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing
Wang, S., Fan, Y., Li, D., Sun, C., Lei, Z., Lu, L., Wang, T., & Zhang, F. (2019) · Nature Communications · doi:10.1038/s41467-019-09043-x · Cited by 510 · see citing works
Bright quantum dots emitting at ∼1,600 nm in the NIR-IIb window for deep tissue fluorescence imaging
Zhang, M., Yue, J., Cui, R., Ma, Z., Wan, H., Wang, F., Zhu, S., Zhou, Y., Kuang, Y., Zhong, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1806153115 · Cited by 432 · see citing works
Flavylium Polymethine Fluorophores for Near‐ and Shortwave Infrared Imaging
Cosco, E. D., Caram, J. R., Bruns, O. T., Franke, D., Day, R. A., Farr, E. P., Bawendi, M. G., & Sletten, E. M. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201706974 · Cited by 415 · see citing works
Self-citationQi, J., Sun, C., Zebibula, A., Zhang, H., Kwok, R. T. K., Zhao, X., Xi, W., Lam, J. W. Y., Qian, J., & Tang, B. Z. (2018) · Advanced Materials · doi:10.1002/adma.201706856 · Cited by 418 · see citing works
Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging
Li, B., Zhao, M., Feng, L., Dou, C., Ding, S., Zhou, G., Lu, L., Zhang, H., Chen, F., Li, X., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16924-z · Cited by 374 · see citing works
Lei, Z., Sun, C., Pei, P., Wang, S., Li, D., Zhang, X., & Zhang, F. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201904182 · Cited by 362 · see citing works
Cellular and Molecular Probing of Intact Human Organs
Zhao, S., Todorov, M. I., Cai, R., -Maskari, R. A., Steinke, H., Kemter, E., Mai, H., Rong, Z., Warmer, M., Stanic, K., et al. (2020) · Cell · doi:10.1016/j.cell.2020.01.030 · Cited by 292 · see citing works
Self-citationA hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging
Wang, T., Wang, S., Liu, Z., He, Z., Yu, P., Zhao, M., Zhang, H., Lu, L., Wang, Z., Wang, Z., et al. (2021) · Nature Materials · doi:10.1038/s41563-021-01063-7 · Cited by 308 · see citing works
Engineering and physical sciences in oncology: challenges and opportunities
Mitchell, M. J., Jain, R. K., & Langer, R. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.83 · Cited by 273 · see citing works
Self-citationNIR-II bioluminescence for in vivo high contrast imaging and in situ ATP-mediated metastases tracing
Lu, L., Li, B., Ding, S., Fan, Y., Wang, S., Sun, C., Zhao, M., Zhao, C.-X., & Zhang, F. (2020) · Nature Communications · doi:10.1038/s41467-020-18051-1 · Cited by 274 · see citing works
Multiplexed NIR‐II Probes for Lymph Node‐Invaded Cancer Detection and Imaging‐Guided Surgery
Tian, R., Ma, H., Zhu, S., Lau, J., Ma, R., Liu, Y., Lin, L., Chandra, S., Wang, S., Zhu, X., et al. (2020) · Advanced Materials · doi:10.1002/adma.201907365 · Cited by 269 · see citing works
NIR-II bioimaging of small organic molecule
Su, Y., Yu, B., Wang, S., Cong, H., & Shen, Y. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120717 · Cited by 251 · see citing works
Light-sheet microscopy in the near-infrared II window
Wang, F., Wan, H., Ma, Z., Zhong, Y., Sun, Q., Tian, Y., Qu, L., Du, H., Zhang, M., Li, L., et al. (2019) · Nature Methods · doi:10.1038/s41592-019-0398-7 · Cited by 237 · see citing works
Qi, J., Sun, C., Li, D., Zhang, H., Yu, W., Zebibula, A., Lam, J. W. Y., Xi, W., Zhu, L., Cai, F., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b02452 · Cited by 226 · see citing works
Fang, Y., Shang, J., Liu, D., Shi, W., Li, X., & Ma, H. (2020) · Journal of the American Chemical Society · doi:10.1021/jacs.0c08187 · Cited by 223 · see citing works
Xanthene-Based NIR-II Dyes for <i>In Vivo</i> Dynamic Imaging of Blood Circulation
Liu, D., He, Z., Zhao, Y., Yang, Y., Shi, W., Li, X., & Ma, H. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c07711 · Cited by 217 · see citing works
Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles
Chen, W., Cheng, C.-A., Cosco, E. D., Ramakrishnan, S., Lingg, J. G. P., Bruns, O. T., Zink, J. I., & Sletten, E. M. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b05195 · Cited by 202 · see citing works
Self-citationNovel aza-BODIPY based small molecular NIR-II fluorophores for <i>in vivo</i> imaging
Bai, L., Sun, P., Liu, Y., Zhang, H., Hu, W., Zhang, W., Liu, Z., Fan, Q., Li, L., & Huang, W. (2019) · Chemical Communications · doi:10.1039/c9cc03378e · Cited by 187 · see citing works
Sun, Y., Ding, F., Zhou, Z., Li, C., Pu, M., Xu, Y., Zhan, Y., Lu, X., Li, H., Yang, G., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817021116 · Cited by 165 · see citing works
Establishing design principles for emissive organic SWIR chromophores from energy gap laws
Friedman, H. C., Cosco, E. D., Atallah, T. L., Jia, S., Sletten, E. M., & Caram, J. R. (2021) · Chem · doi:10.1016/j.chempr.2021.09.001 · Cited by 145 · see citing works
Yang, Y., Sun, C., Wang, S., Yan, K., Zhao, M., Wu, B., & Zhang, F. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202117436 · Cited by 139 · see citing works
Deep learning for in vivo near-infrared imaging
Ma, Z., Wang, F., Wang, W., Zhong, Y., & Dai, H. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021446118 · Cited by 135 · see citing works
Li, Y., Zhang, P., Tang, W., McHugh, K. J., Kershaw, S. V., Jiao, M., Huang, X., Kalytchuk, S., Perkinson, C. F., Yue, S., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c01153 · Cited by 98 · see citing works
Tang, Y., Li, Y., Lu, X., Hu, X., Zhao, H., Hu, W., Lu, F., Fan, Q., & Huang, W. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201807376 · Cited by 96 · see citing works
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Wu, X., Kim, M., Qu, H., & Wang, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-10788-8 · Cited by 58 · see citing works
Chen, M., Feng, Z., Fan, X., Sun, J., Geng, W., Wu, T., Sheng, J., Qian, J., & Xu, Z. (2022) · Nature Communications · doi:10.1038/s41467-022-34274-w · Cited by 57 · see citing works
Tan, J., Yin, K., Ouyang, Z., Wang, R., Pan, H., Wang, Z., Zhao, C., Guo, W., & Gu, X. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c03926 · Cited by 52 · see citing works
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Piwoński, H., Nozue, S., & Habuchi, S. (2022) · ACS Nanoscience Au · doi:10.1021/acsnanoscienceau.1c00038 · Cited by 39 · see citing works
Piwoński, H., Li, W., Wang, Y., Michinobu, T., & Habuchi, S. (2020) · ACS Applied Polymer Materials · doi:10.1021/acsapm.9b00967 · Cited by 36 · see citing works
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Wong, K. C. Y., & Sletten, E. M. (2022) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2022.102131 · Cited by 31 · see citing works
Characterizing short-wave infrared fluorescence of conventional near-infrared fluorophores
Byrd, B. K., Folaron, M. R., Leonor, J. P., Strawbridge, R. R., Cao, X., Brůža, P., & Davis, S. C. (2019) · Journal of Biomedical Optics · doi:10.1117/1.jbo.24.3.035004 · Cited by 22 · see citing works
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Xiang, D., Wang, Z., Zheng, H., Tang, Y., & Li, Q. (2026) · Light: Science & Applications · doi:10.1038/s41377-026-02212-w · Cited by 22 · see citing works
- Authors
- Bruns, O. T., Bischof, T. S., Harris, D. K., Franke, D., Shi, Y., Riedemann, L., Bartelt, A., Jaworski, F. B., Carr, J. A., Rowlands, C. J., Wilson, M. W. B., Chen, O., Wei, H., Hwang, G. W., Montana, D. M., Coropceanu, I., Achorn, O. B., Kloepper, J., Heeren, J., So, P. T. C., Fukumura, D., Jensen, K. F., Jain, R. K., & Bawendi, M. G.
- Affiliations
- Massachusetts Institute of Technology (US)
- Harvard University (US)
- Corresponding author
- Bischof, Thomas S.
- Bawendi, Moungi G.
- ORCID
- Bruns, Oliver T.
- Bischof, Thomas S.
- Franke, Daniel
- Riedemann, Lars
- Bartelt, Alexander
- Carr, Jessica A.
- Rowlands, Christopher J.
- Wilson, Mark W. B.
- Chen, Ou
- Wei, He
- Hwang, Gyu Weon
- Montana, Daniel M.
- Coropceanu, Igor
- Achorn, Odin B.
- Kloepper, Jonas
- Heeren, Joerg
- So, Peter T. C.
- Fukumura, Dai
- Jensen, Klavs F.
- Bawendi, Moungi G.
- Venue
- Nature Biomedical Engineering
- Published
- 2017-04-10
- Volume
- 1
- Issue
- 4
- ISSN
- 2157-846X (ISSN-L)
- PMC
- PMC5673283
- OpenAlex
- W2606668319
- Cited by
- 686
- References
- 48
- Citations by year
- 2026: 43 · 2025: 71 · 2024: 82 · 2023: 52 · 2022: 94 · 2021: 76 · 2020: 100 · 2019: 81 · 2018: 72 · 2017: 15
- FWCI
- 30.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- National Science Foundation (1449291, W911NF-13)
- U.S. Department of Defense (W911NF13D0001, W81XWH1010016, W81XWH)
- U.S. Department of Energy (DESC0001088)
- Evonik Stiftung
- Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Boehringer Ingelheim Fonds
- Deutsche Forschungsgemeinschaft
- Fondation Leducq
- Deutsche Krebshilfe
- National Institutes of Health (-0001, W81XWH, CA151884, U54-CA151884, CA126642, CA080124, 4-P41-EB015871)
- Samsung
- Office of Science (DESC0001088)
- National Defense Science and Engineering Graduate (CFR 168a)
- National Heart, Lung, and Blood Institute (R01HL121386)
- National Eye Institute (R01EY017656)
- National Cancer Institute (CA096915, W81XWH-10-1-0016, R01CA096915, U54CA151884, CA151884, P01CA080124, R01CA126642, R35CA197743, R01CA208205, P50CA165962)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP3DK101024)
- National Institute of Neurological Disorders and Stroke (U01NS090438)
- National Institute of Biomedical Imaging and Bioengineering (P41EB015871)
- Division of Electrical, Communications and Cyber Systems (ECCS-1449291, 1449291)
- Basic Energy Sciences (DE-SC0001088)
- Army Research Office (W911NF–13–D–0001, W911NF-13, W911NF)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Quantum Dots Synthesis And Properties
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- InAs quantum dots, in vivo optical imaging, lipoprotein turnover, multicolor imaging, emission quantum yield, size-tunable emission, deep tissue penetration, functionalized nanoparticles
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