The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Gliogenesis in the outer subventricular zone promotes enlargement and gyrification of the primate cerebrum
Open accessAbstract
Significance: The formation of cortical convolutions of primates, including humans, is one of the most important subjects in developmental neuroscience, but the underlying mechanisms—considered mostly solved toward the end of the 20th century—have become controversial in the last decade. Recent studies suggest that a stem cell zone called the outer subventricular zone (oSVZ) induces gyri to form directly through neurogenesis. Here, we provide evidence in macaque monkey demonstrating that oSVZ neurogenesis is actually complete before gyrification begins and that a major function of the oSVZ is to produce the glial cells associated with the rapid expansion and folding of the cortical surface.
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“In nonhuman primates and human, glial cells seem to somewhat outnumber neurons in the PFC, albeit with regional variation which is likely to contribute to the formation of secondary and tertiary gyri [77–81].”
From Development of prefrontal cortex (2022) · cites this paper as [77]
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Citations
Cites
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“Surgical manipulations including enucleation of the eyes creates changes in white matter ingrowth to the visual cortex, leading to massive changes in the magnitude and pattern of gyrification (2).”
BackgroundMethodSelf-citationCellular Scaling Rules for the Brains of Marsupials: Not as “Primitive” as Expected
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Self-citationNeurons derived from radial glial cells establish radial units in neocortex
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A tension-based theory of morphogenesis and compact wiring in the central nervous system
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Evolution of the neocortex: a perspective from developmental biology
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Self-citationNeurogenic radial glia in the outer subventricular zone of human neocortex
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Cited by
Sorted by citations
Development and arealization of the cerebral cortex
Cadwell, C. R., Bhaduri, A., Mostajo-Radji, M. A., Keefe, M. G., & Nowakowski, T. J. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.009 · Cited by 408
New insights into the development of the human cerebral cortex
Molnár, Z., Clowry, G. J., Šestan, N., Alzu’bi, A., Bakken, T. E., Hevner, R. F., Hüppi, P. S., Kostović, I., RAKIC, P. T., Anton, E. S., et al. (2019) · Journal of Anatomy · doi:10.1111/joa.13055 · Cited by 426
Self-citationDevelopment of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378
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Origins and Proliferative States of Human Oligodendrocyte Precursor Cells
Huang, W., Bhaduri, A., Velmeshev, D., Wang, S., Wang, L., Rottkamp, C. A., Álvarez-Buylla, A., Rowitch, D. H., & Kriegstein, A. R. (2020) · Cell · doi:10.1016/j.cell.2020.06.027 · Cited by 243
Metadata
- Authors
- Rash, B. G., Duque, A., Morozov, Y. M., Arellano, J. I., Micali, N., & Rakic, P.
- Affiliations
- Yale University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2019-03-20
- Volume
- 116
- Issue
- 14
- Pages
- 7089-7094
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6452694
- OpenAlex
- W2923197044
- Semantic Scholar
- 8b7df27ef95b6ee2b283c9946cffa023751cdcb2
- Cited by
- 156
- References
- 46
- Citations by year
- 2026: 11 · 2025: 10 · 2024: 11 · 2023: 26 · 2022: 27 · 2021: 33 · 2020: 26 · 2019: 10
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NIH (DA02399, EY002593)
- Dorys McConnell Duberg (Endowed Chair)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- outer subventricular zone, gliogenesis, cortical folding, cortical expansion, neurogenesis, glial cells, macaque, primate brain development
- MeSH terms
- PAX6 Transcription Factor, Animals, Astrocytes, Embryo, Mammalian, Macaca, Neurons, Oligodendroglia, Primates, Homeodomain Proteins, Lateral Ventricles, Tumor Suppressor Proteins, Cerebrum, Neurogenesis
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