Mycobacterial HflX is a ribosome splitting factor that mediates antibiotic resistance
Open accessAbstract
Significance: The erm41 gene is considered the primary mechanism of intrinsic resistance to macrolides in Mycobacterium abscessus . Here we demonstrate that the hflX gene plays a significant and equally important role as erm41 . We further describe an unusual mechanism of resistance to macrolide-lincosamide antibiotics mediated by the mycobacterial HflX that likely involves the dissociation of antibiotic-stalled ribosomes. An understanding of the various mechanisms employed by bacteria for resistance to an antibiotic is critical in predicting an effective therapeutic regimen against a pathogenic isolate, and can also inform the development of novel drugs.
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Tn-seq, recombineering and CRISPR tools applied to M. abscessus have begun to define genes that make M. abscessus intrinsically resistant to many antibiotics.
“For example, Tn-seq, recombineering and CRISPR tools applied to M. abscessus have begun to define those genes that make M. abscessus intrinsically resistant to many antibiotics (167–170).”
From Mycobacterium smegmatis: The Vanguard of Mycobacterial Research (2023) · cites this paper as [170]
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- Authors
- Rudra, P., Hurst-Hess, K. R., Cotten, K. L., Partida-Miranda, A., & Ghosh, P.
- Affiliations
- New York State Department of Health (US)
- Corresponding author
- Ghosh, Pallavi
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2019-12-23
- Volume
- 117
- Issue
- 1
- Pages
- 629-634
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC6955381
- OpenAlex
- W2997798310
- Cited by
- 53
- References
- 43
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 10 · 2023: 6 · 2022: 6 · 2021: 12 · 2020: 7
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Office of Extramural Research, National Institutes of Health (1 R21 AI146774)
- Cystic Fibrosis Foundation (GHOSH18G0)
- Topics
- Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Keywords
- Mycobacterium abscessus, macrolide resistance, lincosamide resistance, antibiotic resistance mechanisms, ribosome dissociation, ribosome stalling, ribosome-associated chaperones
- MeSH terms
- Protein Domains, Mycobacterium abscessus, Anti-Bacterial Agents, Bacterial Proteins, Humans, Mutation, Mycobacterium Infections, Nontuberculous, Ribosomal Proteins, RNA, Bacterial, RNA, Messenger, Protein Biosynthesis, Gene Expression Regulation, Bacterial, Macrolides, GTP-Binding Proteins, Mycobacterium smegmatis, Drug Resistance, Bacterial, Ribosome Subunits, Large, Bacterial, Lincosamides
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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