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Moderation of mitochondrial respiration mitigates metabolic syndrome of aging

Tavallaie, Mojdeh, Voshtani, Ramouna, Deng, Xinxian, Qiao, Yixue, Jiang, Faqin, Collman, James P., Fu, Lei·2020·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1917948117
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Abstract

Significance: The efforts toward minimizing oxidative stress and maintaining mitochondrial energy metabolism for promoted healthy aging are at the forefront of current research on aging. We have characterized a treatment that, by reversible inhibition of mitochondrial respiration in mice through cytochrome c oxidase (CcO), markedly improves mitochondrial bioenergetics and delays the lead health concerns associated with aging in mice. We demonstrated that chronic moderate inhibition of CcO reduces ATP synthesis, promotes mitochondrial biogenesis and mitophagy, subsequently decreases ROS production and mitochondrial decay, and rectifies vital cellular energy metabolism regulators, thus, effectively refining energy homeostasis and curbing obesity and glucose irregularities linked to aging.

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Metadata

Authors
Tavallaie, M., Voshtani, R., Deng, X., Qiao, Y., Jiang, F., Collman, J. P., & Fu, L.
Affiliations
  • Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, School of Pharmacy, Shanghai Jiao Tong University, 200240 Shanghai, China;
  • Department of Genetics and Immunology, School of Life Sciences, Shanghai Jiao Tong University, 200240 Shanghai, China;
  • Department of Chemistry, Stanford University, Stanford, CA 94305
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2020-04-17
Volume
117
Issue
18
Pages
9840-9850
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1917948117
Cited by
71
References
9
Language
en
Licence
www.pnas.org/site/aboutpnas/licenses.xhtml (vor, 183 d)

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