The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Electrical and chemical synapses among parvalbumin fast-spiking GABAergic interneurons in adult mouse neocortex
Open accessAbstract
Networks of γ-aminobutyric acid (GABA)ergic interneurons connected via electrical and chemical synapses are thought to play an important role in detecting and promoting synchronous activity in the cerebral cortex. Although the properties of electrical and chemical synaptic interactions among inhibitory interneurons are critical for their function as a network, they have only been studied systematically in juvenile animals. Here, we have used transgenic mice expressing the enhanced green fluorescent protein in cells containing parvalbumin (PV) to study the synaptic connectivity among fast-spiking (FS) cells in slices from adult animals (2–7 months old). We have recorded from pairs of PV-FS cells and found that the majority of them were electrically coupled (61%, 14 of 23 pairs). In addition, 78% of the pairs were connected via GABAergic chemical synapses, often reciprocally. The average coupling coefficient for step injections was 1.5% ( n = 14), a smaller value than that reported in juvenile animals. GABA-mediated inhibitory postsynaptic currents and potentials decayed with exponential time constants of 2.6 and 5.9 ms, respectively, and exhibited paired-pulse depression (50-ms interval). The inhibitory synaptic responses in the adult were faster than those observed in young animals. Our results indicate that PV-FS cells are highly interconnected in the adult cerebral cortex by both electrical and chemical synapses, establishing networks that can have important implications for coordinating activity in cortical circuits.
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“PV-INs in the cortex are highly interconnected via electrical and chemical synapses [69].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [69]
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Self-citationWhen inhibition not excitation synchronizes neural firing
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Bartos, M., Vida, I., & Jonas, P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2044 · Cited by 2,070
Neurophysiological and Computational Principles of Cortical Rhythms in Cognition
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How Inhibition Shapes Cortical Activity
Isaacson, J. S., & Scanziani, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.027 · Cited by 1,678
Fast-spiking, parvalbumin + GABAergic interneurons: From cellular design to microcircuit function
Hu, H., Gan, J., & Jonas, P. (2014) · Science · doi:10.1126/science.1255263 · Cited by 1,197
Principles of connectivity among morphologically defined cell types in adult neocortex
Jiang, X., Shen, S., Cadwell, C. R., Berens, P., Sinz, F., Ecker, A. S., Patel, S., & Tolias, A. S. (2015) · Science · doi:10.1126/science.aac9462 · Cited by 908
Metadata
- Authors
- Galarreta, M., & Hestrin, S.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Galarreta, Mario
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-09-04
- Volume
- 99
- Issue
- 19
- Pages
- 12438-12443
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC129463
- OpenAlex
- W1992424371
- Cited by
- 387
- References
- 56
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 26 · 2023: 9 · 2022: 15 · 2021: 11 · 2020: 11 · 2019: 9 · 2018: 13 · 2017: 17 · 2016: 22 · 2015: 14 · 2014: 20 · 2013: 26 · 2012: 22
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Eye Institute (R01EY012114, EY12114)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Keywords
- parvalbumin interneurons, fast-spiking interneurons, electrical synapses, chemical synapses, GABAergic inhibition, neocortex, synaptic connectivity, coupling coefficient, inhibitory postsynaptic potentials, paired-pulse depression, adult mice, cortical circuits
- MeSH terms
- Action Potentials, Animals, Electrochemistry, gamma-Aminobutyric Acid, Interneurons, Luminescent Proteins, Mice, Inbred C57BL, Mice, Inbred ICR, Mice, Transgenic, Parvalbumins, Promoter Regions, Genetic, Recombinant Proteins, Synapses, Neocortex, Green Fluorescent Proteins, Mice, In Vitro Techniques
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