Electrical synapses define networks of neocortical GABAergic neurons
Abstract
Recent work using paired recording has provided a direct demonstration of functional electrical synapses between neocortical neurons of both juvenile and adult animals. Electrical synapses have been found among GABAergic interneurons but not pyramidal cells. Interestingly, necortical electrical synapses almost exclusively connect GABAergic neurons belonging to the same class. So far, at least five different neocortical networks defined by extensive and selective electrical coupling have been studied in the neocortex. These results could provide important clues to the understanding of functional cortical circuitry.
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The low pass coupling coefficient of connections is highly variable but is typically between 1 and 40% (with a mean coupling conductance of 1.6 nS).
“The low pass coupling coefficient of connections is highly variable but is typically between 1 and 40% (with a mean coupling conductance of 1.6 nS) (220, 488).”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [488]
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- Authors
- Hestrin, S., & Galarreta, M.
- Affiliations
- Stanford Medicine (US)
- Corresponding author
- Hestrin, Shaul
- Galarreta, Mario
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 28
- Issue
- 6
- Pages
- 304-309
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W1976280690
- Cited by
- 258
- References
- 52
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 12 · 2016: 13 · 2015: 6 · 2014: 18 · 2013: 18 · 2012: 17
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Eye Institute (R01EY012114, EY12114, EY09120, R01EY009120)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- electrical synapses, gap junctions, GABAergic interneurons, neocortex, cortical circuits, neuronal networks, electrical coupling, pyramidal neurons, paired recordings
- MeSH terms
- Animals, gamma-Aminobutyric Acid, Nerve Net, Neural Inhibition, Neurons, Synapses, Neural Networks, Computer, Gap Junctions, Neocortex
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