Cited by 258Connexins and lens biologyNeural dynamics and brain functionNeuroscience and Neuropharmacology Research

Electrical synapses define networks of neocortical GABAergic neurons

Hestrin, Shaul, Galarreta, Mario·2005·Trends in Neurosciences

Abstract

Recent work using paired recording has provided a direct demonstration of functional electrical synapses between neocortical neurons of both juvenile and adult animals. Electrical synapses have been found among GABAergic interneurons but not pyramidal cells. Interestingly, necortical electrical synapses almost exclusively connect GABAergic neurons belonging to the same class. So far, at least five different neocortical networks defined by extensive and selective electrical coupling have been studied in the neocortex. These results could provide important clues to the understanding of functional cortical circuitry.

Integrity signals

Registry

Crossref · 10.1016/j.tins.2005.04.001

Cites

52 of 52 references verified0 citation errors · 0 not checkable

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  • The low pass coupling coefficient of connections is highly variable but is typically between 1 and 40% (with a mean coupling conductance of 1.6 nS).

    “The low pass coupling coefficient of connections is highly variable but is typically between 1 and 40% (with a mean coupling conductance of 1.6 nS) (220, 488).”

    From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [488]

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Authors
Hestrin, S., & Galarreta, M.
Affiliations
Stanford Medicine (US)
Corresponding author
  • Hestrin, Shaul
  • Galarreta, Mario
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2005-06
Volume
28
Issue
6
Pages
304-309
ISSN
0166-2236 (ISSN-L)
OpenAlex
W1976280690
Cited by
258
References
52
Citations by year
2026: 3 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 8 · 2019: 6 · 2018: 8 · 2017: 12 · 2016: 13 · 2015: 6 · 2014: 18 · 2013: 18 · 2012: 17
FWCI
1.70
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Eye Institute (R01EY012114, EY12114, EY09120, R01EY009120)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connexins and lens biology
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
electrical synapses, gap junctions, GABAergic interneurons, neocortex, cortical circuits, neuronal networks, electrical coupling, pyramidal neurons, paired recordings
MeSH terms
Animals, gamma-Aminobutyric Acid, Nerve Net, Neural Inhibition, Neurons, Synapses, Neural Networks, Computer, Gap Junctions, Neocortex

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