The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells
Open accessAbstract
The effect of various chemical modifications of nitrogen atoms on the efficiency of polyethylenimines (PEIs) as synthetic vectors for the delivery of plasmid DNA into monkey kidney cells in vitro has been systematically investigated. The resultant structure–activity relationship has both provided mechanistic insights and led to PEI derivatives with markedly enhanced performance. For example, N-acylation of PEI with the molecular mass of 25 kDa (PEI25, one of the most potent polycationic gene delivery vectors) with alanine nearly doubles its transfection efficiency in the presence of serum and also lowers its toxicity. Furthermore, dodecylation of primary amino groups of 2-kDa PEI yields a nontoxic polycation whose transfection efficiency in the presence of serum is 400 times higher than the parent's and which exceeds 5-fold even that of PEI25.
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Cites
Measurement of protein using bicinchoninic acid
Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., & Klenk, D. C. (1985) · Analytical Biochemistry · doi:10.1016/0003-2697(85)90442-7 · Cited by 18,482
Ogris, M., Brunner, S., Schüller, S., Kircheis, R., & Wagner, E. (1999) · Gene Therapy · doi:10.1038/sj.gt.3300900 · Cited by 1,178
Non-viral gene delivery systems
Davis, M. E. (2002) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(02)00294-x · Cited by 419
Cited by
Non-viral vectors for gene-based therapy
Yin, H., Kanasty, R. L., Eltoukhy, A. A., Vegas, A. J., Dorkin, J. R., & Anderson, D. G. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3763 · Cited by 3,123
Design and development of polymers for gene delivery
Pack, D. W., Hoffman, A. S., Pun, S., & Stayton, P. S. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1775 · Cited by 2,568
Nonviral vectors for gene delivery
Mintzer, M. A., & Simanek, E. E. (2009) · Chemical Reviews · doi:10.1021/cr800409e · Cited by 2,366
Thomas, M., & Klibanov, A. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1233634100 · Cited by 549
Self-citationBiodegradable poly(amine-co-ester) terpolymers for targeted gene delivery
Zhou, J., Liu, J., Cheng, C. J., Patel, T. R., Weller, C. E., Piepmeier, J. M., Jiang, Z., & Saltzman, W. M. (2012) · Nature Materials · doi:10.1038/nmat3187 · Cited by 389
Metadata
- Authors
- Thomas, M., & Klibanov, A. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-10-25
- Volume
- 99
- Issue
- 23
- Pages
- 14640-14645
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1967078049
- Cited by
- 483
- References
- 3
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- green
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