The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Mitochondria-lysosome contacts regulate mitochondrial Ca2+dynamics via lysosomal TRPML1
Open accessAbstract
Significance: Mitochondria and lysosomes are critical for cellular homeostasis and defects in both organelles are observed in several diseases. Recently, contact sites between mitochondria and lysosomes were identified and found to modulate mitochondrial dynamics. However, whether mitochondria–lysosome contacts have additional functions is unknown. Here, we identify a function of mitochondria–lysosome contacts in facilitating the direct transfer of calcium from lysosomes to mitochondria. Transfer of calcium at mitochondria–lysosome contacts is mediated by the lysosomal channel TRPML1 and is disrupted in mucolipidosis type IV, a lysosomal storage disorder caused by loss-of-function mutations in TRPML1. Calcium transfer from lysosomes to mitochondria at mitochondria–lysosome contacts thus presents an additional mechanism of intracellular calcium regulation that may further contribute to various disorders.
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The lysosome as a cellular centre for signalling, metabolism and quality control
Lawrence, R. E., & Zoncu, R. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0244-7 · Cited by 920
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
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Self-citationMCOLN1 is a ROS sensor in lysosomes that regulates autophagy
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Cited by
Quality control of the mitochondrion
Ng, M. Y. W., Wai, T., & Simonsen, A. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.009 · Cited by 445
The roles of mitochondria in global and local intracellular calcium signalling
Cartes-Saavedra, B., Ghosh, A., & Hajnóczky, G. (2025) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00820-1 · Cited by 126
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Metadata
- Authors
- Peng, W., Wong, Y. C., & Krainc, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2020-07-23
- Volume
- 117
- Issue
- 32
- Pages
- 19266-19275
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W3045202678
- Cited by
- 336
- References
- 11
- FWCI
- 19.56
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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