Diffusion MRI–guided theta burst stimulation enhances memory and functional connectivity along the inferior longitudinal fasciculus in mild cognitive impairment
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Significance: Noninvasive theta burst stimulation (TBS) guided by brain white matter tractography is a promising approach to strengthen resting-state functional connectivity of the hippocampus and increase associative memory performance in individuals with mild cognitive impairment. With this approach, our findings add insight into how TBS propagates from the superficial stimulation site to the hippocampus along the inferior longitudinal fasciculus. Results of this study provide an innovative platform for developing a noninvasive hippocampal stimulation protocol that has great potential in enhancing memory function in mild cognitive impairment.
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Studies have demonstrated enhancement of neurocognitive performance among healthy individuals and clinical populations including MCI, Parkinson disease, stroke, polysubstance use disorder, and schizophrenia.
“Studies have demonstrated enhancement of neurocognitive performance among healthy individuals (Lowe et al., 2018) and clinical populations including MCI (Chen et al., 2022), Parkinson disease (He et al., 2021), stroke (Tsai et al., 2020), polysubstance use disorder (Dong et al., 2023), and schizophrenia (Zhang et al., 2023).”
From Neurocognitive effects of theta burst stimulation for treatment-resistant depression in adults: A systematic review and recommendations for future research (2025) · cites this paper as Chen et al., 2022
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- Authors
- Chen, Y.-C., Ton That, V., Ugonna, C., Liu, Y., Nadel, L., & Chou, Y.-H.
- Affiliations
- University of Arizona (US)
- Department of Psychology, University of Arizona, Tucson, AZ 85721
- Corresponding author
- Nadel, Lynn
- Chou, Ying-hui
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2022-05-20
- Volume
- 119
- Issue
- 21
- Pages
- e2113778119-e2113778119
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC9173759
- OpenAlex
- W4280546963
- Cited by
- 29
- References
- 92
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 2
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute on Aging (R01 AG062543)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- mild cognitive impairment, theta burst stimulation, inferior longitudinal fasciculus, hippocampal functional connectivity, associative memory, resting-state functional connectivity, white matter tractography, Alzheimer's disease prevention, transcranial magnetic stimulation
- MeSH terms
- Humans, Magnetic Resonance Imaging, Memory, Diffusion Magnetic Resonance Imaging, Transcranial Magnetic Stimulation, Cognitive Dysfunction, White Matter
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