Cited by 29Transcranial Magnetic Stimulation StudiesMemory and Neural MechanismsDementia and Cognitive Impairment Research

Diffusion MRI–guided theta burst stimulation enhances memory and functional connectivity along the inferior longitudinal fasciculus in mild cognitive impairment

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Chen, Yu-Chin, Ton That, Viet, Ugonna, Chidi, Liu, Yilin, Nadel, Lynn, Chou, Ying-hui·2022·Proceedings of the National Academy of Sciences

Abstract

Significance: Noninvasive theta burst stimulation (TBS) guided by brain white matter tractography is a promising approach to strengthen resting-state functional connectivity of the hippocampus and increase associative memory performance in individuals with mild cognitive impairment. With this approach, our findings add insight into how TBS propagates from the superficial stimulation site to the hippocampus along the inferior longitudinal fasciculus. Results of this study provide an innovative platform for developing a noninvasive hippocampal stimulation protocol that has great potential in enhancing memory function in mild cognitive impairment.

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Authors
Chen, Y.-C., Ton That, V., Ugonna, C., Liu, Y., Nadel, L., & Chou, Y.-H.
Affiliations
  • University of Arizona (US)
  • Department of Psychology, University of Arizona, Tucson, AZ 85721
Corresponding author
  • Nadel, Lynn
  • Chou, Ying-hui
Venue
Proceedings of the National Academy of Sciences
Published
2022-05-20
Volume
119
Issue
21
Pages
e2113778119-e2113778119
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W4280546963
Cited by
29
References
92
Citations by year
2026: 5 · 2025: 6 · 2024: 8 · 2023: 8 · 2022: 2
FWCI
2.11
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
HHS | NIH | National Institute on Aging (R01 AG062543)
Topics
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
mild cognitive impairment, theta burst stimulation, inferior longitudinal fasciculus, hippocampal functional connectivity, associative memory, resting-state functional connectivity, white matter tractography, Alzheimer's disease prevention, transcranial magnetic stimulation
MeSH terms
Humans, Magnetic Resonance Imaging, Memory, Diffusion Magnetic Resonance Imaging, Transcranial Magnetic Stimulation, Cognitive Dysfunction, White Matter

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