Cited by 470Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsHemispheric Asymmetry in Neuroscience

Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: meta-analyses of MRI studies

Shi, Feng, Liu, Bing, Zhou, Yuan, Yu, Chunshui, Jiang, Tianzi·2009·Hippocampus

Abstract

Numerous studies have reported a smaller hippocampal volume in Alzheimer's disease (AD) patients than in aging controls. However, in mild cognitive impairment (MCI), the results are inconsistent. Moreover, the left-right asymmetry of the hippocampus receives less research attention. In this article, meta-analyses are designed to determine the extent of hippocampal atrophy in MCI and AD, and to evaluate the asymmetry pattern of the hippocampal volume in control, MCI, and AD groups. From 14 studies including 365 MCI patients and 382 controls, significant atrophy is found in both the left [Effect size (ES), 0.92; 95% confidence interval (CI), 0.72-1.11] and right (ES, 0.78; 95% CI, 0.57-0.98) hippocampus, which is lower than that in AD (ES, 1.60, 95% CI, 1.37-1.84, in left; ES, 1.52, 95% CI, 1.31-1.72, in right). Comparing with aging controls, the average volume reduction weighted by sample size is 12.9% and 11.1% in left and right hippocampus in MCI, and 24.2% and 23.1% in left and right hippocampus in AD, respectively. The findings show a bilateral hippocampal volume loss in MCI and the extent of atrophy is less than that in AD. By comparing the left and right hippocampal volume, a consistent left-less-than-right asymmetry pattern is found, but with different extents in control (ES, 0.39), MCI (ES, 0.56), and AD (ES, 0.30) group.

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Crossref · 10.1002/hipo.20573

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  • Extensive hippocampus atrophy is already present in the mild cognitive impairment stage of Alzheimer's disease.

    “Regarding the findings on GM MD changes in MCI subjects, one needs to acknowledge that extensive hippocampus atrophy is already present in the MCI stage of AD (Shi et al., 2009), probably confounding the measurement of GM MD values due to partial volume effects (PVE).”
  • Hippocampal atrophy is detectable prior to the diagnosis of Alzheimer's disease, at the stage of amnestic Mild Cognitive Impairment or earlier in asymptomatic elderly.

    “Using MRI, this atrophy is detectable prior to the diagnosis of AD, at the stage of amnestic Mild Cognitive Impairment (aMCI) (Convit et al., 1997; Shi et al., 2009) or even earlier, in asymptomatic elderly up to 10 years before the diagnosis of dementia (Smith et al., 2007; Tondelli et al., 2012).”

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Authors
Shi, F., Liu, B., Zhou, Y., Yu, C., & Jiang, T.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Capital Medical University (CN)
Corresponding author
Jiang, Tianzi
Venue
Hippocampus
Publisher
Wiley
Published
2009-03-23
Volume
19
Issue
11
Pages
1055-1064
ISSN
  • 1050-9631 (ISSN-L)
  • 1098-1063
OpenAlex
W2130622075
Cited by
470
References
78
Citations by year
2026: 23 · 2025: 34 · 2024: 18 · 2023: 31 · 2022: 33 · 2021: 34 · 2020: 38 · 2019: 29 · 2018: 29 · 2017: 37 · 2016: 30 · 2015: 28 · 2014: 22 · 2013: 21 · 2012: 28
FWCI
2.61
Type
journal article
Language
en
Open access
closed
Locations
  • Hippocampus (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
Keywords
hippocampal volume, hippocampal asymmetry, mild cognitive impairment, Alzheimer's disease, hippocampal atrophy, brain aging, left-right asymmetry
MeSH terms
Adult, Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Cognition Disorders, Cross-Sectional Studies, Female, Hippocampus, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Confidence Intervals, MEDLINE

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