Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer's disease: meta-analyses of MRI studies
Abstract
Numerous studies have reported a smaller hippocampal volume in Alzheimer's disease (AD) patients than in aging controls. However, in mild cognitive impairment (MCI), the results are inconsistent. Moreover, the left-right asymmetry of the hippocampus receives less research attention. In this article, meta-analyses are designed to determine the extent of hippocampal atrophy in MCI and AD, and to evaluate the asymmetry pattern of the hippocampal volume in control, MCI, and AD groups. From 14 studies including 365 MCI patients and 382 controls, significant atrophy is found in both the left [Effect size (ES), 0.92; 95% confidence interval (CI), 0.72-1.11] and right (ES, 0.78; 95% CI, 0.57-0.98) hippocampus, which is lower than that in AD (ES, 1.60, 95% CI, 1.37-1.84, in left; ES, 1.52, 95% CI, 1.31-1.72, in right). Comparing with aging controls, the average volume reduction weighted by sample size is 12.9% and 11.1% in left and right hippocampus in MCI, and 24.2% and 23.1% in left and right hippocampus in AD, respectively. The findings show a bilateral hippocampal volume loss in MCI and the extent of atrophy is less than that in AD. By comparing the left and right hippocampal volume, a consistent left-less-than-right asymmetry pattern is found, but with different extents in control (ES, 0.39), MCI (ES, 0.56), and AD (ES, 0.30) group.
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Extensive hippocampus atrophy is already present in the mild cognitive impairment stage of Alzheimer's disease.
“Regarding the findings on GM MD changes in MCI subjects, one needs to acknowledge that extensive hippocampus atrophy is already present in the MCI stage of AD (Shi et al., 2009), probably confounding the measurement of GM MD values due to partial volume effects (PVE).”
From Mean diffusivity in cortical gray matter in Alzheimer's disease: The importance of partial volume correction (2018) · cites this paper as Shi et al., 2009
Hippocampal atrophy is detectable prior to the diagnosis of Alzheimer's disease, at the stage of amnestic Mild Cognitive Impairment or earlier in asymptomatic elderly.
“Using MRI, this atrophy is detectable prior to the diagnosis of AD, at the stage of amnestic Mild Cognitive Impairment (aMCI) (Convit et al., 1997; Shi et al., 2009) or even earlier, in asymptomatic elderly up to 10 years before the diagnosis of dementia (Smith et al., 2007; Tondelli et al., 2012).”
From Hippocampal subfield volumetry in mild cognitive impairment, Alzheimer's disease and semantic dementia (2013) · cites this paper as Shi et al., 2009
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- Authors
- Shi, F., Liu, B., Zhou, Y., Yu, C., & Jiang, T.
- Affiliations
- Chinese Academy of Sciences (CN)
- Capital Medical University (CN)
- Corresponding author
- Jiang, Tianzi
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2009-03-23
- Volume
- 19
- Issue
- 11
- Pages
- 1055-1064
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- OpenAlex
- W2130622075
- Cited by
- 470
- References
- 78
- Citations by year
- 2026: 23 · 2025: 34 · 2024: 18 · 2023: 31 · 2022: 33 · 2021: 34 · 2020: 38 · 2019: 29 · 2018: 29 · 2017: 37 · 2016: 30 · 2015: 28 · 2014: 22 · 2013: 21 · 2012: 28
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Keywords
- hippocampal volume, hippocampal asymmetry, mild cognitive impairment, Alzheimer's disease, hippocampal atrophy, brain aging, left-right asymmetry
- MeSH terms
- Adult, Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Cognition Disorders, Cross-Sectional Studies, Female, Hippocampus, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Confidence Intervals, MEDLINE
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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