The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A high-speed atomic force microscope for studying biological macromolecules
Open accessAbstract
The atomic force microscope (AFM) is a powerful tool for imaging individual biological molecules attached to a substrate and placed in aqueous solution. At present, however, it is limited by the speed at which it can successively record highly resolved images. We sought to increase markedly the scan speed of the AFM, so that in the future it can be used to study the dynamic behavior of biomolecules. For this purpose, we have developed a high-speed scanner, free of resonant vibrations up to 60 kHz, small cantilevers with high resonance frequencies (450–650 kHz) and small spring constants (150–280 pN/nm), an objective-lens type of deflection detection device, and several electronic devices of wide bandwidth. Integration of these various devices has produced an AFM that can capture a 100 × 100 pixel 2 image within 80 ms and therefore can generate a movie consisting of many successive images (80-ms intervals) of a sample in aqueous solution. This is demonstrated by imaging myosin V molecules moving on mica (see http://www.s.kanazawa-u.ac.jp/phys/biophys/bmv_movie.htm ).
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Cites
Direct observation of single kinesin molecules moving along microtubules
Vale, R. D., Funatsu, T., Pierce, D. W., Romberg, L., Harada, Y., & Yanagida, T. (1996) · Nature · doi:10.1038/380451a0 · Cited by 711
Cited by
AFM: a versatile tool in biophysics
Alessandrini, A., & Facci, P. (2005) · Measurement Science and Technology · doi:10.1088/0957-0233/16/6/r01 · Cited by 384
Shibata, M., Yamashita, H., Uchihashi, T., Kandori, H., & Ando, T. (2010) · Nature Nanotechnology · doi:10.1038/nnano.2010.7 · Cited by 320
Self-citationInner lumen proteins stabilize doublet microtubules in cilia and flagella
Owa, M., Uchihashi, T., Yanagisawa, H.-A., Yamano, T., Iguchi, H., Fukuzawa, H., Wakabayashi, K.-I., Ando, T., & Kikkawa, M. (2019) · Nature Communications · doi:10.1038/s41467-019-09051-x · Cited by 140
Self-citationSample preparation procedures for biological atomic force microscopy
EL KIRAT, K., BURTON, I., DUPRES, V., & DUFRENE, Y. F. (2005) · Journal of Microscopy · doi:10.1111/j.1365-2818.2005.01480.x · Cited by 130
Preparation of DNA and nucleoprotein samples for AFM imaging
Lyubchenko, Y. L. (2011) · Micron · doi:10.1016/j.micron.2010.08.011 · Cited by 93
Metadata
- Authors
- Ando, T., Kodera, N., Takai, E., Maruyama, D., Saito, K., & Toda, A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-10-09
- Volume
- 98
- Issue
- 22
- Pages
- 12468-12472
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2167235502
- Cited by
- 1,102
- References
- 1
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Ando, T., Kodera, N., Takai, E., Maruyama, D., Saito, K., & Toda, A. (2001). A high-speed atomic force microscope for studying biological macromolecules. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.211400898
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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