Intestinal commensal microbiota and cytokines regulate Fut2 + Paneth cells for gut defense

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

Trapnell, C., Roberts, A., Goff, L. A., Pertea, G. M., Kim, D., Kelley, D. R., Pimentel, H., Salzberg, S. L., Rinn, J. L., & Pachter, L. S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.016 · Cited by 11,930 · see citing works

Identification of stem cells in small intestine and colon by marker gene Lgr5

Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687 · see citing works

Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis

Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251 · see citing works

Rab GTPases as coordinators of vesicle traffic

Stenmark, H. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2728 · Cited by 3,413 · see citing works

RAG-1-deficient mice have no mature B and T lymphocytes

Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S., & Papaioannou, V. E. (1992) · Cell · doi:10.1016/0092-8674(92)90030-g · Cited by 2,898 · see citing works

Practical Flow Cytometry

Shapiro, H. M. (2003) · Wiley eBooks · doi:10.1002/0471722731 · Cited by 2,698 · see citing works

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Sato, T., van Es, J. H., Snippert, H. J., Stange, D. E., Vries, R. G., van den Born, M., Barker, N., Shroyer, N. F., van de Wetering, M., & Clevers, H. (2011) · Nature · doi:10.1038/nature09637 · Cited by 2,510 · see citing works

Microbial Influences in Inflammatory Bowel Diseases

Sartor, R. B. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.11.059 · Cited by 1,927 · see citing works

New approach for understanding genome variations in KEGG

Kanehisa, M. I., Sato, Y., Furumichi, M., Morishima, K., & Tanabe, M. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky962 · Cited by 1,845 · see citing works

A single-cell survey of the small intestinal epithelium

Haber, A. L., Biton, M., Rogel, N., Herbst, R. H., Shekhar, K., Smillie, C., Burgin, G., Delorey, T. M., Howitt, M. R., Katz, Y., et al. (2017) · Nature · doi:10.1038/nature24489 · Cited by 1,750 · see citing works

A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells

Cadwell, K., Liu, J. Y., Brown, S. L., Miyoshi, H., Loh, J., Lennerz, J. K., Kishi, C., Kc, W., Carrero, J. A., Hunt, S., et al. (2008) · Nature · doi:10.1038/nature07416 · Cited by 1,542 · see citing works

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

Kaser, A., Lee, A.-H., Franke, A., Glickman, J., Zeissig, S., Tilg, H., Nieuwenhuis, E., Higgins, D. E., Schreiber, S., Glimcher, L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.021 · Cited by 1,442 · see citing works

Mucin dynamics and enteric pathogens

McGuckin, M. A., Lindén, S. K., Sutton, P., & Florin, T. H. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2538 · Cited by 1,428 · see citing works

Targeting IL-17 and TH17 cells in chronic inflammation

Miossec, P., & Kolls, J. K. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3794 · Cited by 1,414 · see citing works

Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration

Barker, N. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3721 · Cited by 1,334 · see citing works

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

Cella, M., Fuchs, A. G., Vermi, W., Facchetti, F., Otero, K., Lennerz, J. K., Doherty, J. M., Mills, J. C., & Colonna, M. (2008) · Nature · doi:10.1038/nature07537 · Cited by 1,245 · see citing works

Mammalian defensins in the antimicrobial immune response

Selsted, M. E., & Ouellette, A. J. (2005) · Nature Immunology · doi:10.1038/ni1206 · Cited by 1,196 · see citing works

Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

Lindemans, C. A., Calafiore, M., Mertelsmann, A. M., O'Connor, M. H., Dudakov, J. A., Jenq, R. R., Velardi, E., Young, L. F., Smith, O. M., Lawrence, G., et al. (2015) · Nature · doi:10.1038/nature16460 · Cited by 1,112 · see citing works

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

Satoh‐Takayama, N., Vosshenrich, C. A. J., Lesjean‐Pottier, S., Sawa, S., Lochner, M., Rattis, F. M., Mention, J., Thiam, K., Cerf–Bensussan, N., Mandelboim, O., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.11.001 · Cited by 1,086 · see citing works

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., López-Boado, Y. S., Stratman, J. L., Hultgren, S. J., Matrisian, L. M., & Parks, W. C. (1999) · Science · doi:10.1126/science.286.5437.113 · Cited by 1,076 · see citing works

Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria

Ayabe, T., Satchell, D. P., Wilson, C. L., Parks, W. C., Selsted, M. E., & Ouellette, A. J. (2000) · Nature Immunology · doi:10.1038/77783 · Cited by 1,060 · see citing works

Antigen-Specific T Cell Sensitization Is Impaired in IL-17-Deficient Mice, Causing Suppression of Allergic Cellular and Humoral Responses

Nakae, S., Komiyama, Y., Nambu, A., Sudo, K., Iwase, M., Homma, I., Sekikawa, K., Asano, M., & Iwakura, Y. (2002) · Immunity · doi:10.1016/s1074-7613(02)00391-6 · Cited by 1,053 · see citing works

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

Sonnenberg, G. F., Fouser, L. A., & Artis, D. (2011) · Nature Immunology · doi:10.1038/ni.2025 · Cited by 1,041 · see citing works

RORγt and commensal microflora are required for the differentiation of mucosal interleukin 22–producing NKp46+ cells

Sanos, S. L., Bui, V. L., Mortha, A., Oberle, K., Heners, C., Johner, C., & Diefenbach, A. (2008) · Nature Immunology · doi:10.1038/ni.1684 · Cited by 843 · see citing works

Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria

Sonnenberg, G. F., Monticelli, L. A., Alenghat, T., Fung, T. C., Hutnick, N. A., Kunisawa, J., Shibata, N., Grunberg, S., Sinha, R., Zahm, A. M., et al. (2012) · Science · doi:10.1126/science.1222551 · Cited by 738 · see citing works

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

Klose, C. S. N., Kiss, E. A., Schwierzeck, V., Ebert, K., Hoyler, T., d’Hargues, Y., Göppert, N., Croxford, A. L., Waisman, A., Tanriver, Y., et al. (2013) · Nature · doi:10.1038/nature11813 · Cited by 722 · see citing works

Paneth Cells: Maestros of the Small Intestinal Crypts

Clevers, H. C., & Bevins, C. L. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183744 · Cited by 699 · see citing works

Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells

Farin, H. F., Van Es, J. H., & Clevers, H. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.08.031 · Cited by 655 · see citing works

Innate lymphoid cells regulate intestinal epithelial cell glycosylation

Goto, Y., Obata, T., Kunisawa, J., Sato, S., Ivanov, I. I., Lamichhane, A., Takeyama, N., Kamioka, M., Sakamoto, M., Matsuki, T., et al. (2014) · Science · doi:10.1126/science.1254009 · Cited by 568 · see citing works

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

Pickard, J. M., Maurice, C. F., Kinnebrew, M. A., Abt, M. C., Schenten, D., Golovkina, T. V., Bogatyrev, S. R., Ismagilov, R. F., Pamer, E. G., Turnbaugh, P. J., et al. (2014) · Nature · doi:10.1038/nature13823 · Cited by 535 · see citing works

Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation

Goto, Y., Panea, C., Nakato, G., Cebula, A., Lee, C., Diez, M. G., Laufer, T. M., Ignatowicz, L., & Ivanov, I. I. (2014) · Immunity · doi:10.1016/j.immuni.2014.03.005 · Cited by 465 · see citing works

The multifaceted Paneth cell

Porter, E. M., Bevins, C. L., Ghosh, D., & Ganz, T. (2002) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-002-8412-z · Cited by 423 · see citing works

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

Wong, V. W. Y., Stange, D. E., Page, M. E., Buczacki, S. J. A., Wabik, A., Itami, S., van de Wetering, M., Poulsom, R., Wright, N. A., Trotter, M. W. B., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2464 · Cited by 409 · see citing works

Suppression of concanavalin A-induced hepatitis in IFN-gamma(-/-) mice, but not in TNF-alpha(-/-) mice: role for IFN-gamma in activating apoptosis of hepatocytes

Tagawa, Y., Sekikawa, K., & Iwakura, Y. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.3.1418 · Cited by 401 · see citing works

Mucosal Ecological Network of Epithelium and Immune Cells for Gut Homeostasis and Tissue Healing

Kurashima, Y., & Kiyono, H. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052424 · Cited by 331 · see citing works

IL-22 Is Expressed by Th17 Cells in an IL-23-Dependent Fashion, but Not Required for the Development of Autoimmune Encephalomyelitis

Kreymborg, K., Etzensperger, R., Dumoutier, L., Haak, S., Rebollo, A., Buch, T., Heppner, F. L., Renauld, J., & Becher, B. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.12.8098 · Cited by 330 · see citing works

Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation

Kumar, P., Monin, L., Castillo, P., Elsegeiny, W., Horne, W., Eddens, T., Vikram, A., Good, M., Schoenborn, A. A., Bibby, K., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.007 · Cited by 326 · see citing works

Epithelial IL-22RA1-Mediated Fucosylation Promotes Intestinal Colonization Resistance to an Opportunistic Pathogen

Pham, T. A. N., Clare, S., Goulding, D., Arasteh, J. M., Stares, M., Browne, H. P., Keane, J. A., Page, A. J., Kumasaka, N., Kane, L., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.08.017 · Cited by 305 · see citing works

Paneth Cell Multipotency Induced by Notch Activation following Injury

Yu, S., Tong, K., Zhao, Y., Balasubramanian, I., Yap, G. S., Ferraris, R. P., Bonder, E. M., Verzi, M. P., & Gao, N. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.05.002 · Cited by 281 · see citing works

Paneth cell extrusion and release of antimicrobial products is directly controlled by immune cell–derived IFN-γ

Farin, H. F., Karthaus, W. R., Kujala, P., Rakhshandehroo, M., Schwank, G., Vries, R. G. J., Kalkhoven, E., Nieuwenhuis, E. E. S., & Clevers, H. C. (2014) · The Journal of Experimental Medicine · doi:10.1084/jem.20130753 · Cited by 268 · see citing works

A common role for Atg16L1, Atg5, and Atg7 in small intestinal Paneth cells and Crohn disease

Cadwell, K., Patel, K. K., Komatsu, M., Virgin, IV, & Stappenbeck, T. S. (2009) · Autophagy · doi:10.4161/auto.5.2.7560 · Cited by 224 · see citing works

Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota

Nagao‐Kitamoto, H., Leslie, J. L., Kitamoto, S., Jin, C., Thomsson, K. A., Gillilland, M. G., Kuffa, P., Goto, Y., Jenq, R. R., Ishii, C., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0764-0 · Cited by 220 · see citing works

Novel functions of the polymeric Ig receptor: well beyond transport of immunoglobulins

Phalipon, A., & Corthésy, B. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(02)00031-5 · Cited by 213 · see citing works

Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells.

Farr, A. G., & Anderson, S. K. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.134.5.2971 · Cited by 127 · see citing works

R-Spondin1 expands Paneth cells and prevents dysbiosis induced by graft-versus-host disease

Hayase, E., Hashimoto, D., Nakamura, K., Noizat, C., Ogasawara, R., Takahashi, S., Ohigashi, H., Yokoi, Y., Sugimoto, R., Matsuoka, S., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170418 · Cited by 120 · see citing works

Paneth cell α-defensins and enteric microbiota in health and disease

Nakamura, K., Sakuragi, N., Takakuwa, A., & Ayabe, T. (2015) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2015-019 · Cited by 118 · see citing works

Dysbiosis—A consequence of Paneth cell dysfunction

Salzman, N. H., & Bevins, C. L. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.09.006 · Cited by 110 · see citing works

Essential role of IFN-γ in T cell–associated intestinal inflammation

Eriguchi, Y., Nakamura, K., Yokoi, Y., Sugimoto, R., Takahashi, S., Hashimoto, D., Teshima, T., Ayabe, T., Selsted, M. E., & Ouellette, A. J. (2018) · JCI Insight · doi:10.1172/jci.insight.121886 · Cited by 108 · see citing works

Deficiency of Reproductive Tract α(1,2)Fucosylated Glycans and Normal Fertility in Mice with Targeted Deletions of the FUT1 or FUT2 α(1,2)Fucosyltransferase Locus

Domino, S. E., Zhang, L., Gillespie, P. J., Saunders, T. L., & Lowe, J. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.24.8336-8345.2001 · Cited by 102 · see citing works

Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids

Yokoi, Y., Nakamura, K., Yoneda, T., Kikuchi, M., Sugimoto, R., Shimizu, Y., & Ayabe, T. (2019) · Scientific Reports · doi:10.1038/s41598-019-39610-7 · Cited by 83 · see citing works

Distinct fucosylation of M cells and epithelial cells by Fut1 and Fut2, respectively, in response to intestinal environmental stress

Terahara, K., Nochi, T., Yoshida, M., Takahashi, Y., Goto, Y., Hatai, H., Kurokawa, S., Jang, M. H., Kweon, M.-N., Domino, S. E., et al. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.12.067 · Cited by 61 · see citing works

Decreased secretion of Paneth cell α‐defensins in graft‐versus‐host disease

Eriguchi, Y., Nakamura, K., Hashimoto, D., Shimoda, S., Shimono, N., Akashi, K., Ayabe, T., & Teshima, T. (2015) · Transplant Infectious Disease · doi:10.1111/tid.12423 · Cited by 57 · see citing works

Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory γδ T Cell Subsets

Serre, K., & Silva‐Santos, B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00431 · Cited by 40 · see citing works

Fecal microbiota transplantation prevents Candida albicans from colonizing the gastrointestinal tract

Matsuo, K., Haku, A., Bi, B., Takahashi, H., Kamada, N., Yaguchi, T., Saijo, S., Yoneyama, M., & Goto, Y. (2019) · Microbiology and Immunology · doi:10.1111/1348-0421.12680 · Cited by 34 · see citing works

Polymeric Immunoglobulin Receptor

Aroeti, B., Casanova, J. E., Okamoto, C. T., Cardone, M. H., Pollack, A. L., Tang, K., & Mostov, K. E. (1993) · International review of cytology · doi:10.1016/s0074-7696(08)62603-0 · Cited by 32 · see citing works

GDP-fucose: β-galactoside α1,2-fucosyltransferase, MFUT-II, and not MFUT-I or -III, is induced in a restricted region of the digestive tract of germ-free mice by host-microbe interactions and cycloheximide

Lin, B., Hayashi, Y., Saito, M., Sakakibara, Y., Yanagisawa, M., & Iwamori, M. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00103-7 · Cited by 30 · see citing works

A monoclonal antibody-based sandwich enzyme-linked immunosorbent assay for detection of secreted α-defensin

Nakamura, K., Sakuragi, N., & Ayabe, T. (2013) · Analytical Biochemistry · doi:10.1016/j.ab.2013.08.021 · Cited by 26 · see citing works

Expression of Polymeric Immunoglobulin Receptor mRNA and Protein in Human Paneth Cells: Paneth Cells Participate in Acquired Immunity

Tang, Q., Wang, L., Tao, K.-Z., Ge, C., Li, J., Peng, Y., Jiang, C., & Geng, M. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00605.x · Cited by 14 · see citing works

Simultaneous real-time analysis of Paneth cell and intestinal stem cell response to interferon-γ by a novel stem cell niche tracking method

Yokoi, Y., Adachi, T., Sugimoto, R., Kikuchi, M., Ayabe, T., & Nakamura, K. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.01.050 · Cited by 11 · see citing works

Fucose promotes intestinal stem cell-mediated intestinal epithelial development through promoting Akkermansia -related propanoate metabolism

Duan, C., Wu, J., Wang, Z., Tan, C., Hou, L., Qian, W., Han, C., & Hou, X. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2233149 · Cited by 90 · see citing works

Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cells

Ohara, D., Takeuchi, Y., & Hirota, K. (2024) · Cellular and Molecular Immunology · doi:10.1038/s41423-024-01218-x · Cited by 63 · see citing works

Bacterial extracellular vesicles at the interface of gut microbiota and immunity

Melo-Marques, I., Cardoso, S. M., & Empadinhas, N. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2396494 · Cited by 59 · see citing works

Innate lymphoid cells: More than just immune cells

Xiong, L., Nutt, S. L., & Seillet, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1033904 · Cited by 49 · see citing works

Gene–environment interactions shape the host–microbial interface in inflammatory bowel disease

Cadwell, K., & Loke, P. (2025) · Nature Immunology · doi:10.1038/s41590-025-02197-5 · Cited by 41 · see citing works

Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis

Hong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38 · see citing works

From birth to death: The hardworking life of Paneth cell in the small intestine

Cui, C., Wang, F., Zheng, Y., Wei, H., & Peng, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1122258 · Cited by 34 · see citing works

The role of group 3 innate lymphoid cell in intestinal disease

Li, M., Wang, Z., Jiang, W., Lu, Y., & Zhang, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1171826 · Cited by 33 · see citing works

Host–pathobiont interactions in Crohn’s disease

Caruso, R., Lo, B. C., Chen, G., & Núñez, G. (2024) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-024-00997-y · Cited by 35 · see citing works

IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum

Brabec, T., Vobořil, M., Schierová, D., Valter, E., Šplíchalová, I., Dobeš, J., Březina, J., Dobešová, M., Aidarova, A., Jakubec, M., et al. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.01.005 · Cited by 32 · see citing works

Interactions between host and intestinal crypt-resided biofilms are controlled by epithelial fucosylation

Guo, X.-K., Wang, J., van Hensbergen, V. P., Liu, J., Xu, H., & Hu, X. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112754 · Cited by 26 · see citing works

The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation

Merchak, A. R., Cahill, H. J., Brown, L. C., Brown, R. M., Rivet-Noor, C. R., Beiter, R. M., Slogar, E. R., Olgun, D. G., & Gaultier, A. (2023) · PLoS Biology · doi:10.1371/journal.pbio.3002000 · Cited by 24 · see citing works

Infection and inflammation stimulate expansion of a CD74+ Paneth cell subset to regulate disease progression

Balasubramanian, I., Bandyopadhyay, S., Flores, J., Bianchi‐Smak, J., Lin, X., Liu, H., Sun, S., Golovchenko, N. B., Liu, Y., Wang, D., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2023113975 · Cited by 23 · see citing works

Bile acid-dependent transcription factors and chromatin accessibility determine regional heterogeneity of intestinal antimicrobial peptides

Wang, Y., Yu, Y., Li, L., Zheng, M., Zhou, J., Gong, H., Feng, B., Wang, X., Meng, X., Cui, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40565-7 · Cited by 21 · see citing works

Lentinan mitigates ulcerative colitis via the IL-22 pathway to repair the compromised mucosal barrier and enhance antimicrobial defense

Zhang, Y., Zhou, Z., Zhang, Z., Liu, Y., Ji, W., Wang, J., Wang, K., & Li, Q. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141784 · Cited by 17 · see citing works

The Role of the Gut Microbiome in the Development of Acute Pancreatitis

Zhou, R., Wu, Q., Yang, Z., Cai, Y., Wang, D., & Wu, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021159 · Cited by 19 · see citing works

Gut microbiota-mediated IL-22 alleviates metabolic inflammation

Wang, K., Zhou, M., Si, H., & Ma, J. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122229 · Cited by 16 · see citing works

Potential consequences of phototoxicity on cell function during live imaging of intestinal organoids

Yokoi, Y., Nakamura, R., Ohira, S., Takemi, S., Ayabe, T., & Nakamura, K. (2024) · PLoS ONE · doi:10.1371/journal.pone.0313213 · Cited by 15 · see citing works

Old mitochondria regulate niche renewal via α-ketoglutarate metabolism in stem cells

Andersson, S., Bui, H. M., Viitanen, A., Borshagovski, D., Salminen, E. S., Kilpinen, S. K., Gebhart, A., Kuuluvainen, E., Gopalakrishnan, S., Peltokangas, N., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01325-7 · Cited by 15 · see citing works

Interleukin-22: the hub bridging gut homeostasis and metabolism.

Wang, S.-P., Gong, J., Wang, J.-X., Wang, W.-L., & Huang, L.-H. (2025) · Trends in immunology · doi:10.1016/j.it.2025.10.009 · Cited by 18 · see citing works

Mechanisms conferring multi-layered protection against intestinal Salmonella Typhimurium infection

Kroon, S., & Hardt, W. (2025) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf038 · Cited by 14 · see citing works

ATG16L1 protects from interferon-γ-induced cell death in the small intestinal crypt

Foerster, E. G., Tsang, D. K. L., Goyal, S., Robertson, S. J., Robert, L. M., Maughan, H., Streutker, C., Girardin, S. E., & Philpott, D. J. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.02.001 · Cited by 14 · see citing works

Mechanisms of Potential Therapeutic Utilization of Mesenchymal Stem Cells in COVID-19 Treatment

Fang, Y., Lao, P., Tang, L., Chen, J., Chen, Y., Sun, L., Tan, W., & Fan, X. (2023) · Cell Transplantation · doi:10.1177/09636897231184611 · Cited by 13 · see citing works

Bacteria‐responsive transformable peptide‐based nanomaterials inspired by human α‐defensin 6 for labeling and entrapping pathogenic bacteria

Zhou, C., Tang, Q., Tan, P., Wang, T., Zhang, Y., Yang, S., Zhao, G., Feng, Y., & Ma, X. (2025) · Responsive materials · doi:10.1002/rpm.20240029 · Cited by 12 · see citing works

A purified diet affects intestinal epithelial proliferation and barrier functions through gut microbial alterations

Shiratori, H., Hattori, K. M., Nakata, K., Okawa, T., Komiyama, S., Kinashi, Y., Kabumoto, Y., Kaneko, Y., Nagai, M., Shindo, T., et al. (2024) · International Immunology · doi:10.1093/intimm/dxae003 · Cited by 12 · see citing works

Dachengqi decoction ameliorated liver injury in liver fibrosis mice by maintaining gut vascular barrier integrity

Shuhan, W., Li, J.-X., Shang, L., Liuying, C., Fangyuan, Z., Mengqi, Z., Qifeng, L., Yuju, C., Junli, Z., Yao, W., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156272 · Cited by 12 · see citing works

Lactiplantibacillus plantarum L47 and inulin alleviate enterotoxigenic Escherichia coli induced ileal inflammation in piglets by upregulating the levels of α-linolenic acid and 12,13-epoxyoctadecenoic acid

Cui, L., Zeng, H., Hou, M., Li, Z., Mu, C., Zhu, W., & Hang, S. (2023) · Animal nutrition · doi:10.1016/j.aninu.2023.06.008 · Cited by 11 · see citing works

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Zhang, Z., Tanaka, I., Nakahashi-Ouchida, R., Ernst, P. B., Kiyono, H., & Kurashima, Y. (2024) · Seminars in Immunopathology · doi:10.1007/s00281-023-00999-z · Cited by 11 · see citing works

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Wang, T., Sun, H., Zhang, M., Shen, P., & Li, Y. (2024) · BMC Gastroenterology · doi:10.1186/s12876-024-03287-8 · Cited by 11 · see citing works

Reg3α concentrations at day of allogeneic stem cell transplantation predict outcome and correlate with early antibiotic use

Weber, D., Weber, M., Meedt, E., Ghimire, S., Wolff, D., Edinger, M., Poeck, H., Hiergeist, A., Gessner, A., Ayuk, F., et al. (2023) · Blood Advances · doi:10.1182/bloodadvances.2022008480 · Cited by 11 · see citing works

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Yao, Y., Qian, C., Chang, Z., Yang, J., Chen, Y., Wang, H., Zhu, J., Xiao, Y., Li, Y., Zhao, J., et al. (2023) · Food & Function · doi:10.1039/d3fo00820g · Cited by 10 · see citing works

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Iguchi, E., Takai, A., Oe, N., Fujii, Y., Omatsu, M., Takeda, H., Shimizu, T., Maruno, T., Nakanishi, Y., Yoshinaga, M., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2500820122 · Cited by 9 · see citing works

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Liao, J., Bi, S., Fang, Z., Deng, Q., Chen, Y., Sun, L., Jiang, Y., Huang, L., & Gooneratne, R. (2023) · Molecules · doi:10.3390/molecules28104217 · Cited by 8 · see citing works

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Yang, J., & Shi, Y. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1184159 · Cited by 7 · see citing works

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Uemura, I., Takahashi‐Suzuki, N., Kita, F., & Satoh, T. (2024) · MethodsX · doi:10.1016/j.mex.2024.102952 · Cited by 7 · see citing works

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Liu, J., Jiang, Z., Zha, J., Lin, Q., & He, W. (2025) · Genes & Diseases · doi:10.1016/j.gendis.2025.101650 · Cited by 7 · see citing works

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Ohira, S., Yokoi, Y., Ayabe, T., & Nakamura, K. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.11.008 · Cited by 7 · see citing works

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Yamazaki, F., KOBAYASHI, K., Mochizuki, J., & Sashihara, T. (2024) · FEMS Microbiology Letters · doi:10.1093/femsle/fnae006 · Cited by 6 · see citing works

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Li, Y., Fang, Z., Zhou, X., Gao, J., Wang, J., Huang, L., Chen, Y., Sun, L., Deng, Q., & Gooneratne, R. (2022) · Molecules · doi:10.3390/molecules28010177 · Cited by 6 · see citing works

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Zhang, Y., Li, B., Hong, Y., Luo, P., Hong, Z., Xia, X., Mo, P., Yu, C., & Chen, W. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012316 · Cited by 5 · see citing works

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Horiuchi, K., Higashiyama, M., Tahara, H., Yoshidome, Y., Ayaki, K., Nishimura, H., Tomioka, A., Narimatsu, K., Komoto, S., Tomita, K., et al. (2024) · Digestive Diseases and Sciences · doi:10.1007/s10620-024-08581-9 · Cited by 5 · see citing works

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Ma, Z., Wen, X., Zhang, Y., Ai, Z., Zhao, X., Dong, N., Dou, X., & Shan, A. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c10406 · Cited by 5 · see citing works

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Liang, L., Zhang, X., & Nian, X. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1765775 · Cited by 4 · see citing works

Paneth cells as orchestrators of epithelial barrier defense and emerging therapeutic targets in inflammatory bowel disease

Erkert, L., Haag, L.-M., & Becker, C. (2026) · Seminars in Immunopathology · doi:10.1007/s00281-026-01068-x · Cited by 4 · see citing works

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Jiang, C. Q., Zhu, F., Aimaier, S., Zhang, L., Ali, M. H., Fan, F., Lu, Y., Jia, M., Wu, D., Yin, H., et al. (2025) · Foods · doi:10.3390/foods14183199 · Cited by 3 · see citing works

Ileal Crohn’s Disease Exhibits Reduced Activity of Phospholipase C-β3-Dependent Wnt/β-Catenin Signaling Pathway

Ando, T., Takazawa, I., Spencer, Z. T., Ito, R., Tomimori, Y., Mikulski, Z., Matsumoto, K., Ishitani, T., Denson, L. A., Kawakami, Y., et al. (2024) · Cells · doi:10.3390/cells13110986 · Cited by 3 · see citing works

Fucosyltransferase 2 is involved in immune-related functions in Penaeus vannamei by modulating antimicrobial peptides’ expression

Liu, Y., Jiang, M., Zheng, Z., Yao, D., Yang, S., Yang, C., Zhang, Y., & Aweya, J. J. (2022) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2022.104611 · Cited by 2 · see citing works

TREM2 promotes susceptibility to colitis through the induction of gut microbiota dysbiosis

Seo, J.-E., Seon, J.-E., Yee, S., Koo, H.-S., Moon, S.-H., Seo, H.-J., Seo, J.-H., Kim, S., Choi, H., & Kang, H.-S. (2026) · Cellular Immunology · doi:10.1016/j.cellimm.2026.105062 · Cited by 1 · see citing works

Cytokine networks in Paneth cell regulation

Yu, Z., Campos, C. Y., & Theiss, A. L. (2026) · Mucosal Immunology · doi:10.1016/j.mucimm.2026.01.010 · Cited by 1 · see citing works

The architecture of gut microecological networks and the governance of host metabolic homeostasis

Chen, X. G., You, W., & Zhou, S. H. E. N. G. H. (2026) · Mycology&#58 An International Journal on Fungal Biology · doi:10.1080/21501203.2026.2684091 · Cited by 1 · see citing works

Precisely with William Haseltine: How Innate Lymphoid Cells Help Keep Us Healthy Against COVID-19

Haseltine, W. A. (2022) · Inside Precision Medicine · doi:10.1089/ipm.09.03.08 · Cited by 1 · see citing works

Intestinal Barrier Glycosylation for Gut Physiology and Pathology

Kim, G., Ye, D., Yao, Y., & Wu, C. (2025) · Barrier Immunity · doi:10.1002/dni2.70000

Safflower Polysaccharides Alleviate Ulcerative Colitis by Modulating Gut ImmunityPreprint

Jiang, C. Q., Zhang, L., Ali, M. H., Zhu, F., Fan, F., Lu, Y., Jia, M., Wu, D., Yin, H., Wei, J., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5319608

Gut Barrier Permeability, Microbiota, and Brain Health

Madison, A. A., Duff, A. F., & Bailey, M. T. (2025) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190931544.013.17

Advances in the interaction between gut microbiota and post-translational modifications of proteins

Zhao, L., He, H., Luo, Z., Jin, L., & Xiao, B. (2025) · Microbiological Research · doi:10.1016/j.micres.2025.128349

Research progress of IL-22 <?A3B2 pi129?>in radiation-induced intestinal injury

Lei, Z. H. U., ZHANG, Z.-G., Li, G. U. O., Wang, J. Y., & Liu, J.-Y. (2026) · Shengming kexue · doi:10.3724/cbls.2026022

A case report of soluble A antigen confounding the blood type in a haplo‐identical hematopoietic stem cell transplant patient with graft‐versus‐host disease

Hugan, S., Naiyer, N., & Cooling, L. L. W. (2026) · Transfusion · doi:10.1111/trf.70221

FUT2-mediated α1,2-fucosylation in inflammatory bowel disease: mechanisms and translational potential

Chen, J., Gan, L., Zhang, S., Liao, S., & Lv, L. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12396-4

Pathophysiology of the gut–eye axis in a Sjögren's disease‐like dry eye mouse model: An exploratory evaluation of dietary heat‐treated Enterococcus faecalis FK‐23

Goto, K., Takemura, S., Minamiyama, Y., & Yoshikawa, T. (2026) · Experimental Physiology · doi:10.1113/ep093816

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Zhao, L., & Zhang, N. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1926158

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Xu, Z., Song, D., Hu, F., Liang, Q., Zhang, M., Lei, C., Li, J., Guo, H., Deng, Z., & Yang, Z. (2026) · Biomolecules · doi:10.3390/biom16091226

Sulfate Groups Modulate the Protective Effects of Laminaria japonica Fucoidan against High-Fat Diet-Induced Intestinal Mucus Layer Injury via Gut Microbiota Regulation and Metabolic Profiling

Li, H., Chen, J., Zhang, C., Cai, W., Che, H., & Li, H. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6c08201

Interleukin-22 receptor signaling in Paneth cells is critical for their maturation and antimicrobial function

Gaudino, S. J., Beaupre, M., Lin, X., Rathi, S., McLaughlin, P., Mehta, N., Eskiocak, O., Yueh, B., van der Velden, A. W. M., Beyaz, S., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.204.supp.60.9

IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity

Gaudino, S. J., Beaupre, M., Lin, X., Joshi, P., Rathi, S., McLaughlin, P. A., Kempen, C. G., Mehta, N., Eskiocak, O., Yueh, B., et al. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-00348-5 · Cited by 77 · see citing works

Paneth cells, defensins, and the commensal microbiota: A hypothesis on intimate interplay at the intestinal mucosa

Salzman, N. H., Underwood, M. A., & Bevins, C. L. (2007) · Seminars in Immunology · doi:10.1016/j.smim.2007.04.002 · Cited by 414 · see citing works

Ptpn2: A Critical Regulator of Paneth Cell Homeostasis

Theiss, A. L. (2023) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2023.03.010 · Cited by 3 · see citing works

The role of Paneth cells and their antimicrobial peptides in innate host defense

Ayabe, T., Ashida, T., Kohgo, Y., & Kono, T. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.06.007 · Cited by 124 · see citing works