Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T _reg Cell Homeostasis

Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works

IL-17 and th17 cells

Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873 · see citing works

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554 · see citing works

Interactions Between the Microbiota and the Immune System

Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173 · see citing works

Induction of Colonic Regulatory T Cells by Indigenous <i>Clostridium</i> Species

Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752 · see citing works

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872 · see citing works

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866 · see citing works

Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria

Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554 · see citing works

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

Kitamura, D., Roes, J., Kühn, R., & Rajewsky, K. (1991) · Nature · doi:10.1038/350423a0 · Cited by 1,783 · see citing works

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770 · see citing works

Interactions between commensal intestinal bacteria and the immune system

Macpherson, A. J., & Harris, N. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1373 · Cited by 1,607 · see citing works

Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells

Wu, H.-J., Ivanov, I. I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D. R., Benoist, C., & Mathis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.001 · Cited by 1,577 · see citing works

Defective TCR expression in transgenic mice constructed using cDNA‐based α‐ and β‐chain genes under the control of heterologous regulatory elements

Barnden, M., Allison, J., Heath, W. R., & Carbone, F. (1998) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.1998.00709.x · Cited by 1,491 · see citing works

The Key Role of Segmented Filamentous Bacteria in the Coordinated Maturation of Gut Helper T Cell Responses

Gaboriau-Routhiau, V., Rakotobe, S., Lécuyer, E., Mulder, I., Lan, A., Bridonneau, C., Rochet, V., Pisi, A., De Paepe, M., Brandi, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.020 · Cited by 1,452 · see citing works

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

Lee, Y. K., Menezes, J. S., Umesaki, Y., & Mazmanian, S. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000082107 · Cited by 1,323 · see citing works

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

Berer, K., Mues, M., Koutrolos, M., Rasbi, Z. A., Boziki, M., Johner, C., Wekerle, H., & Krishnamoorthy, G. (2011) · Nature · doi:10.1038/nature10554 · Cited by 1,251 · see citing works

ATP drives lamina propria TH17 cell differentiation

Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., Onoue, M., Yagita, H., Ishii, N., Evans, R., Honda, K., et al. (2008) · Nature · doi:10.1038/nature07240 · Cited by 1,089 · see citing works

Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen

Caton, M. L., Smith-Raska, M., & Reizis, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062648 · Cited by 864 · see citing works

Mice lacking MHC class II molecules

Cosgrove, D. E., Gray, D., Dierich, A., Kaufman, J., LeMeur, M., Benoist, C. O., & Mathis, D. J. (1991) · Cell · doi:10.1016/0092-8674(91)90448-8 · Cited by 853 · see citing works

Tumor-specific Th17-polarized cells eradicate large established melanoma

Muranski, P. J., Boni, A., Antony, P. A., Cassard, L., Irvine, K. R., Kaiser, A., Paulos, C. M., Palmer, D. C., Touloukian, C. E., Ptak, K., et al. (2008) · Blood · doi:10.1182/blood-2007-11-120998 · Cited by 838 · see citing works

The microbiome in infectious disease and inflammation

Honda, K., & Littman, D. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074937 · Cited by 791 · see citing works

Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria

Hepworth, M. R., Monticelli, L. A., Fung, T. C., Ziegler, C. G. K., Grunberg, S., Sinha, R., Mantegazza, A. R., Ma, H., Crawford, A., Angelosanto, J., et al. (2013) · Nature · doi:10.1038/nature12240 · Cited by 780 · see citing works

cis Elements of the Villin Gene Control Expression in Restricted Domains of the Vertical (Crypt) and Horizontal (Duodenum, Cecum) Axes of the Intestine

Madison, B., Dunbar, L., Qiao, X. T., Braunstein, K., Braunstein, E. M., & Gumucio, D. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204935200 · Cited by 748 · see citing works

Depletion of CD4 + T Cells in Major Histocompatibility Complex Class II-Deficient Mice

Grusby, M. J., Johnson, R. S., Papaioannou, V. E., & Glimcher, L. H. (1991) · Science · doi:10.1126/science.1910207 · Cited by 660 · see citing works

Intestinal Bacteria and the Regulation of Immune Cell Homeostasis

Hill, D. A., & Artis, D. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101330 · Cited by 586 · see citing works

Thymic Origin of Intestinal αß T Cells Revealed by Fate Mapping of RORγt + Cells

Eberl, G., & Littman, D. R. (2004) · Science · doi:10.1126/science.1096472 · Cited by 514 · see citing works

In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

Fagarasan, S., Kinoshita, K., Muramatsu, M., Ikuta, K., & Honjo, T. (2001) · Nature · doi:10.1038/35098100 · Cited by 430 · see citing works

Intestinal Commensal Microbes as Immune Modulators

Ivanov, I. I., & Honda, K. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.09.009 · Cited by 425 · see citing works

Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora

Qiu, J., Guo, X., Chen, Z. E., He, L., Sonnenberg, G. F., Artis, D., Fu, Y., & Zhou, L. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.002 · Cited by 415 · see citing works

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo

Darrasse-Jèze, G., Deroubaix, S., Mouquet, H., Victora, G. D., Eisenreich, T., Yao, K.-H., Masilamani, R. F., Dustin, M. L., Rudensky, A. Y., Liu, K., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090746 · Cited by 404 · see citing works

CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice.

Cardell, S., Tangri, S., Chan, S. H., Kronenberg, M., Benoist, C. O., & Mathis, D. J. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.4.993 · Cited by 384 · see citing works

Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation

Torchinsky, M. B., Garaude, J., Martin, A. P., & Blander, J. M. (2009) · Nature · doi:10.1038/nature07781 · Cited by 364 · see citing works

Segmented Filamentous Bacteria Are Indigenous Intestinal Bacteria That Activate Intraepithelial Lymphocytes and Induce MHC Class II Molecules and Fucosyl Asialo GM1 Glycolipids on the Small Intestinal Epithelial Cells in the Ex‐Germ‐Free Mouse

Umesaki, Y., Okada, Y., Matsumoto, S., Imaoka, A., & Setoyama, H. (1995) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1995.tb02242.x · Cited by 346 · see citing works

Two better cell lines for making hybridomas expressing specific T cell receptors.

White, J., Blackman, M. A., Bill, J. R., Kappler, J. W., Marrack, P., Gold, D. P., & Born, W. K. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.6.1822 · Cited by 294 · see citing works

Antigen processing and presentation by intestinal epithelial cells – polarity and complexity

Hershberg, R. M., & Mayer, L. (2000) · Immunology Today · doi:10.1016/s0167-5699(99)01575-3 · Cited by 289 · see citing works

Nonself-Antigens Are the Cognate Specificities of Foxp3+ Regulatory T Cells

Pacholczyk, R., Kern, J., Singh, N., Iwashima, M., Kraj, P. J., & Ignatowicz, L. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.019 · Cited by 216 · see citing works

Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut

Fritz, J. H., Rojas, O. L., Simard, N. N., McCarthy, D. D., Hapfelmeier, S., Rubino, S. J., Robertson, S. J., Larijani, M., Gosselin, J., Ivanov, I. I., et al. (2011) · Nature · doi:10.1038/nature10698 · Cited by 203 · see citing works

The Genome of Th17 Cell-Inducing Segmented Filamentous Bacteria Reveals Extensive Auxotrophy and Adaptations to the Intestinal Environment

Sczesnak, A., Segata, N., Qin, X., Gevers, D., Petrosino, J. F., Huttenhower, C., Littman, D. R., & Ivanov, I. I. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.08.005 · Cited by 186 · see citing works

T Helper 1 and T Helper 2 Cells Are Pathogenic in an Antigen-specific Model of Colitis

Iqbal, N., Oliver, J. R., Wagner, F. H., Lazenby, A. J., Elson, C. O., & Weaver, C. T. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.2001889 · Cited by 141 · see citing works

Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense

Farache, J., Zigmond, E., Shakhar, G., & Jung, S. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2012.79 · Cited by 128 · see citing works

T cell tolerance and immunity to commensal bacteria

Nutsch, K., & Hsieh, C. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.04.009 · Cited by 101 · see citing works

A conditional null allele of the major histocompatibility IA‐beta chain gene

Hashimoto, K., Joshi, S. K., & Koni, P. A. (2002) · genesis · doi:10.1002/gene.10056 · Cited by 87 · see citing works

Restricted Microbiota and Absence of Cognate TCR Antigen Leads to an Unbalanced Generation of Th17 Cells

Lochner, M., Berard, M., Sawa, S., Hauer, S., Gaboriau‐Routhiau, V., Fernández, T. D., Snel, J., Bousso, P., Cerf–Bensussan, N., & Eberl, G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001723 · Cited by 80 · see citing works

Postgestational Lymphotoxin/Lymphotoxin β Receptor Interactions Are Essential for the Presence of Intestinal B Lymphocytes

Newberry, R. D., McDonough, J. S., McDonald, K. G., & Lorenz, R. G. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.4988 · Cited by 55 · see citing works

Differential effects of two probiotic strains with different bacteriological properties on intestinal gene expression, with special reference to indigenous bacteria

Shima, T., Fukushima, K., Setoyama, H., Imaoka, A., Matsumoto, S., Hara, T., Suda, K., & Umesaki, Y. (2007) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2007.00344.x · Cited by 51 · see citing works

CD8α+ and CD11b+ Dendritic Cell-Restricted MHC Class II Controls Th1 CD4+ T Cell Immunity

Lemos, M. P., Fan, L., Lo, D. D., & Laufer, T. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.5077 · Cited by 48 · see citing works

Mononuclear phagocyte diversity in the intestine

Bogunovic, M., Mortha, A., Muller, P. A., & Mérad, M. (2012) · Immunologic Research · doi:10.1007/s12026-012-8323-5 · Cited by 30 · see citing works

Regional specialization within the intestinal immune system

Mowat, A. M., & Agace, W. W. (2014) · Nature reviews. Immunology · doi:10.1038/nri3738 · Cited by 1,769 · see citing works

Th17 cell induction by adhesion of microbes to intestinal epithelial cells

Atarashi, K., Tanoue, T., Ando, M., Kamada, N., Nagano, Y., Narushima, S., Suda, W., Imaoka, A., Setoyama, H., Nagamori, T., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.058 · Cited by 1,071 · see citing works

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

Pitt, J. M., Vétizou, M., Daillère, R., Roberti, M. P., Yamazaki, T., Routy, B., Lepage, P., Boneca, I. G., Chamaillard, M., Kroemer, G., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.06.001 · Cited by 1,040 · see citing works

Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System

Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876 · see citing works

The Balance of Th17 versus Treg Cells in Autoimmunity

Lee, G. R. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030730 · Cited by 868 · see citing works

Dendritic cell migration in health and disease

Worbs, T., Hammerschmidt, S. I., & Förster, R. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.116 · Cited by 826 · see citing works

Commensal–dendritic-cell interaction specifies a unique protective skin immune signature

Naik, S., Bouladoux, N., Linehan, J. L., Han, S.-J., Harrison, O. J., Wilhelm, C., Conlan, S., Himmelfarb, S., Byrd, A. L., Deming, C., et al. (2015) · Nature · doi:10.1038/nature14052 · Cited by 820 · see citing works

Interaction Between the Microbiota, Epithelia, and Immune Cells in the Intestine

Kayama, H., Okumura, R., & Takeda, K. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-070119-115104 · Cited by 765 · see citing works

Impact of microbiota on central nervous system and neurological diseases: the gut-brain axis

Ma, Q., Xing, C., Long, W., Wang, H. Y., Liu, Q., & Wang, R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1434-3 · Cited by 752 · see citing works

Polyethylene microplastics affect the distribution of gut microbiota and inflammation development in mice

Li, B., Ding, Y., Cheng, X., Sheng, D., Xu, Z., Rong, Q., Wu, Y., Zhao, H., Ji, X., & Zhang, Y. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.125492 · Cited by 711 · see citing works

Dialogue between skin microbiota and immunity

Belkaid, Y., & Segre, J. A. (2014) · Science · doi:10.1126/science.1260144 · Cited by 749 · see citing works

Immunological pathogenesis of inflammatory bowel disease

Lee, S., Kwon, J. E., & Cho, M. (2018) · Intestinal Research · doi:10.5217/ir.2018.16.1.26 · Cited by 581 · see citing works

The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome

Omenetti, S., & Pizarro, T. T. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00639 · Cited by 529 · see citing works

Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria–specific CD4 + T cells

Hepworth, M. R., Fung, T. C., Masur, S. H., Kelsen, J. R., McConnell, F. M., Dubrot, J., Withers, D. R., Hugues, S., Farrar, M. A., Reith, W., et al. (2015) · Science · doi:10.1126/science.aaa4812 · Cited by 515 · see citing works

Innate lymphoid cells in the initiation, regulation and resolution of inflammation

Sonnenberg, G. F., & Artis, D. (2015) · Nature Medicine · doi:10.1038/nm.3892 · Cited by 503 · see citing works

Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases

Mahmud, M. R., Akter, S., Tamanna, S. K., Mazumder, L., Esti, I. Z., Banerjee, S., Akter, S., Hasan, M. R., Acharjee, M., Hossain, M. S., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2096995 · Cited by 498 · see citing works

Identifying species of symbiont bacteria from the human gut that, alone, can induce intestinal Th17 cells in mice

Tan, T. G., Sefik, E., Geva-Zatorsky, N., Kua, L., Naskar, D., Teng, F., Pasman, L., Ortiz-Lopez, A., Jupp, R., Wu, H.-J. J., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617460113 · Cited by 427 · see citing works

Functions of Murine Dendritic Cells

Durai, V., & MURPHY, K. M. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.010 · Cited by 406 · see citing works

The dichotomous nature of T helper 17 cells

Stockinger, B., & Omenetti, S. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.50 · Cited by 399 · see citing works

Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site

Horai, R., Zárate-Bladés, C. R., Dillenburg-Pilla, P., Chen, J., Kielczewski, J. L., Silver, P. B., Jittayasothorn, Y., Chan, C.-C., Yamane, H., Honda, K., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.014 · Cited by 402 · see citing works

Weaning stress and intestinal health of piglets: A review

Tang, X., Xiong, K., Fang, R., & Li, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1042778 · Cited by 390 · see citing works

CX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22

Longman, R., Diehl, G. E., Victorio, D., Huh, J. R., Galan, C., Miraldi, E. R., Swaminath, A., Bonneau, R., Scherl, E., & Littman, D. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20140678 · Cited by 376 · see citing works

Mucosal immunity to pathogenic intestinal bacteria

Pérez-López, A., Behnsen, J., Nuccio, S., & Raffatellu, M. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2015.17 · Cited by 374 · see citing works

Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome

Kawano, Y., Edwards, M., Huang, Y., Bilate, A. M., Araujo, L. P., Tanoue, T., Atarashi, K., Ladinsky, M. S., Reiner, S. L., Wang, H. H., et al. (2022) · Cell · doi:10.1016/j.cell.2022.08.005 · Cited by 349 · see citing works

Partners in Leaky Gut Syndrome: Intestinal Dysbiosis and Autoimmunity

Kinashi, Y., & Hase, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.673708 · Cited by 362 · see citing works

Microbiome-modulated metabolites at the interface of host immunity

Blacher, E., Levy, M., Tatirovsky, E., & Elinav, E. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601247 · Cited by 354 · see citing works

Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism

Mao, K., Baptista, A. P., Tamoutounour, S., Zhuang, L., Bouladoux, N. J., Martins, A. J., Huang, Y., Gerner, M. Y., Belkaid, Y., & Germain, R. N. (2018) · Nature · doi:10.1038/nature25437 · Cited by 355 · see citing works

Why Is Initial Bacterial Colonization of the Intestine Important to Infants' and Children's Health?

Houghteling, P. D., & Walker, W. A. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000597 · Cited by 342 · see citing works

The Function and Role of the Th17/Treg Cell Balance in Inflammatory Bowel Disease

Yan, J., Luo, M., Chen, Z., & He, B. (2020) · Journal of Immunology Research · doi:10.1155/2020/8813558 · Cited by 344 · see citing works

Immune-microbiota interactions in health and disease

Palm, N. W., de Zoete, M. R., & Flavell, R. A. (2015) · Clinical Immunology · doi:10.1016/j.clim.2015.05.014 · Cited by 315 · see citing works

Modulation of immune development and function by intestinal microbiota

Kabat, A. M., Srinivasan, N., & Maloy, K. J. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.07.010 · Cited by 312 · see citing works

Gut Microbiota Regulation of T Cells During Inflammation and Autoimmunity

Brown, E., Kenny, D. J., & Xavier, R. J. (2019) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042718-041841 · Cited by 310 · see citing works

The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

Garidou, L., Pomié, C., Klopp, P., Waget, A., Charpentier, J., Aloulou, M., Giry, A., Serino, M., Stenman, L., Lahtinen, S., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.001 · Cited by 303 · see citing works

TGF-β in inflammatory bowel disease: a key regulator of immune cells, epithelium, and the intestinal microbiota

Ihara, S., Hirata, Y., & Koike, K. (2017) · Journal of Gastroenterology · doi:10.1007/s00535-017-1350-1 · Cited by 300 · see citing works

Gut Microbiota Drive Autoimmune Arthritis by Promoting Differentiation and Migration of Peyer’s Patch T Follicular Helper Cells

Teng, F., Klinger, C. N., Felix, K. M., Bradley, C. P., Wu, E., Tran, N. L., Umesaki, Y., & Wu, H.-J. J. (2016) · Immunity · doi:10.1016/j.immuni.2016.03.013 · Cited by 281 · see citing works

The impacts of natural polysaccharides on intestinal microbiota and immune responses – a review

Tang, C., Ding, R., Sun, J. G., Liu, J., Kan, J., & Jin, C. (2019) · Food & Function · doi:10.1039/c8fo01946k · Cited by 281 · see citing works

Metabolic control of regulatory T cell development and function

Zeng, H., & Chi, H. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.08.003 · Cited by 275 · see citing works

Adaptive immune education by gut microbiota antigens

Zhao, Q. S., & Elson, C. O. (2018) · Immunology · doi:10.1111/imm.12896 · Cited by 272 · see citing works

Functional interactions between innate lymphoid cells and adaptive immunity

Sonnenberg, G. F., & Hepworth, M. R. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0194-8 · Cited by 271 · see citing works

A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation

Kedmi, R., Najar, T. A., Mesa, K. R., Grayson, A., Kroehling, L., Hao, Y., Hao, S., Pokrovskii, M. V., Xu, M., Talbot, J., et al. (2022) · Nature · doi:10.1038/s41586-022-05089-y · Cited by 261 · see citing works

Human Gut Bacterial Metabolism Drives Th17 Activation and Colitis

Alexander, M., Ang, Q. Y., Nayak, R. R., Bustion, A. E., Sandy, M., Zhang, B., Upadhyay, V., Pollard, K. S., Lynch, S. V., & Turnbaugh, P. J. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2021.11.001 · Cited by 264 · see citing works

Nutrients Mediate Intestinal Bacteria–Mucosal Immune Crosstalk

Ma, N., Guo, P., Zhang, J., He, T., Kim, S. W., Zhang, G., & Ma, X. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00005 · Cited by 249 · see citing works

Microbiota-mediated inflammation and antimicrobial defense in the intestine

Caballero, S., & Pamer, E. G. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120238 · Cited by 238 · see citing works

Prebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence

Frei, R., Akdis, M., & O’Mahony, L. (2015) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000151 · Cited by 240 · see citing works

Toll-like receptor 4–mediated lymphocyte influx induces neonatal necrotizing enterocolitis

Egan, C. E., Sodhi, C. P., Good, M. L., Lin, J., Jia, H., Yamaguchi, Y., Lu, P., Ma, C., Branca, M. F., Weyandt, S., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci83356 · Cited by 233 · see citing works

The microbiome and autoimmunity: a paradigm from the gut–liver axis

Li, B., Selmi, C. F., Tang, R., Gershwin, M. E., & Ma, X. (2018) · Cellular and Molecular Immunology · doi:10.1038/cmi.2018.7 · Cited by 234 · see citing works

Pouring fuel on the fire: Th17 cells, the environment, and autoimmunity

Burkett, P. R., zu Hörste, G. M., & Kuchroo, V. K. (2015) · Journal of Clinical Investigation · doi:10.1172/jci78085 · Cited by 221 · see citing works

Role of the Gut Microbiome in Modulating Arthritis Progression in Mice

Liu, X., Zeng, B., Zhang, J., Li, W., Mou, F., Wang, H., Zou, Q., Zhong, B., Wu, L., Wei, H., et al. (2016) · Scientific Reports · doi:10.1038/srep30594 · Cited by 245 · see citing works

Modulation of bone remodeling by the gut microbiota: A new therapy for osteoporosis

Lyu, Z., Hu, Y., Guo, Y., & Liu, D. (2023) · Bone Research · doi:10.1038/s41413-023-00264-x · Cited by 207 · see citing works

Functional and phenotypic heterogeneity of group 3 innate lymphoid cells

Melo-González, F., & Hepworth, M. R. (2016) · Immunology · doi:10.1111/imm.12697 · Cited by 199 · see citing works

Segmented Filamentous Bacteria Provoke Lung Autoimmunity by Inducing Gut-Lung Axis Th17 Cells Expressing Dual TCRs

Bradley, C. P., Teng, F., Felix, K. M., Sano, T., Naskar, D., Block, K. E., Huang, H., Knox, K. S., Littman, D. R., & Wu, H.-J. J. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.10.007 · Cited by 197 · see citing works

Toll-like receptors and chronic inflammation in rheumatic diseases: new developments

Joosten, L. A. B., Abdollahi‐Roodsaz, S., Dinarello, C. A., O'Neill, L. A. J., & Netea, M. G. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.61 · Cited by 196 · see citing works

Ageing of the gut microbiome: Potential influences on immune senescence and inflammageing

Conway, J., & Duggal, N. A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101323 · Cited by 194 · see citing works

Regionalized Development and Maintenance of the Intestinal Adaptive Immune Landscape

Agace, W. W., & McCoy, K. D. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.004 · Cited by 185 · see citing works

The Th17/Treg Cell Balance: A Gut Microbiota-Modulated Story

Cheng, H., Guan, X., Chen, D., & Ma, W. (2019) · Microorganisms · doi:10.3390/microorganisms7120583 · Cited by 181 · see citing works

The Immunological Basis of Inflammatory Bowel Disease

Silva, F. A. R., Rodrigues, B. L., Ayrizono, M. D. L. S., & Leal, R. F. (2016) · Gastroenterology Research and Practice · doi:10.1155/2016/2097274 · Cited by 178 · see citing works

Disturbances of the Gut Microbiota and Microbiota-Derived Metabolites in Inflammatory Bowel Disease

Hu, Y., Chen, Z., Xu, C., Kan, S., & Chen, D. (2022) · Nutrients · doi:10.3390/nu14235140 · Cited by 175 · see citing works

Microbial Activities and Intestinal Homeostasis: A Delicate Balance Between Health and Disease

Ohland, C., & Jobin, C. (2014) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2014.11.004 · Cited by 172 · see citing works

Pathogens, microbiome and the host: emergence of the ecological Koch's postulates

Vonaesch, P., Anderson, M. C., & Sansonetti, P. J. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy003 · Cited by 170 · see citing works

Endocytosis of commensal antigens by intestinal epithelial cells regulates mucosal T cell homeostasis

Ladinsky, M. S., Araújo, L. P., Zhang, X., Veltri, J., Galán-Díez, M., Soualhi, S., Lee, C., Irie, K., Pinker, E. Y., Narushima, S., et al. (2019) · Science · doi:10.1126/science.aat4042 · Cited by 170 · see citing works

The role of gut microbiota in bone homeostasis

Behera, J., Ison, J., Tyagi, S. C., & Tyagi, N. (2020) · Bone · doi:10.1016/j.bone.2020.115317 · Cited by 162 · see citing works

Ovariectomy induces bone loss via microbial-dependent trafficking of intestinal TNF+ T cells and Th17 cells.

Yu, M.-C., Pal, S., Paterson, C. W., Li, J., Tyagi, A. M., Adams, J. W., Coopersmith, C., Weitzmann, M., & Pacifici, R. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143137 · Cited by 150 · see citing works

Microbiota metabolites modulate the T helper 17 to regulatory T cell (Th17/Treg) imbalance promoting resilience to stress-induced anxiety- and depressive-like behaviors

Westfall, S., Caracci, F., Zhao, D., Wu, Q.-L., Frolinger, T., Simon, J. E., & Pasinetti, G. M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.10.013 · Cited by 162 · see citing works

Rhubarb Peony Decoction ameliorates ulcerative colitis in mice by regulating gut microbiota to restoring Th17/Treg balance

Luo, S., Wen, R., Wang, Q., Zhao, Z., Nong, F., Fu, Y., Huang, S., Chen, J., Zhou, L., & Luo, X. (2018) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2018.08.033 · Cited by 160 · see citing works

A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease

Kanai∥, T., Mikami, Y., & Hayashi, A. (2015) · Journal of Gastroenterology · doi:10.1007/s00535-015-1084-x · Cited by 160 · see citing works

Antibacterial Weapons: Targeted Destruction in the Microbiota

Chassaing, B., & Cascalès, E. (2018) · Trends in Microbiology · doi:10.1016/j.tim.2018.01.006 · Cited by 160 · see citing works

Intestinal monocyte-derived macrophages control commensal-specific Th17 responses

Panea, C., Farkas, A. M., Goto, Y., Abdollahi-Roodsaz, S., Lee, C., Koscsó, B., Gowda, K., Hohl, T. M., Bogunovic, M., & Ivanov, I. I. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.040 · Cited by 152 · see citing works

Microbial view of central nervous system autoimmunity

Berer, K., & Krishnamoorthy, G. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.04.007 · Cited by 150 · see citing works

Deconstructing Mechanisms of Diet-Microbiome-Immune Interactions

Alexander, M., & Turnbaugh, P. J. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.015 · Cited by 150 · see citing works

The involvement of TH17 cells in the pathogenesis of IBD

Jiang, P., Zheng, C., Xiang, Y., Malik, S., Su, D., Xu, G., & Zhang, M. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.07.005 · Cited by 150 · see citing works

Targeting the gut microbiota-related metabolites for osteoporosis: The inextricable connection of gut-bone axis

Zhang, Y., Wu, Y. Q., Liu, X.-F., Chen, X., & Su, J. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102196 · Cited by 153 · see citing works

The intestinal microbiome in spondyloarthritis

Gill, T., Asquith, M. J., Rosenbaum, J. T., & Colbert, R. A. (2015) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000187 · Cited by 143 · see citing works

IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria

Flannigan, K. L., Ngo, V. L., Geem, D., Harusato, A., Hirota, S. A., Parkos, C. A., Lukacs, N. W., Nusrat, A., Gaboriau‐Routhiau, V., Cerf–Bensussan, N., et al. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.80 · Cited by 142 · see citing works

Mechanisms of Pediatric Inflammatory Bowel Disease

Peloquin, J. M., Goel, G., Villablanca, E. J., & Xavier, R. J. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112151 · Cited by 138 · see citing works

Episodic Aspiration with Oral Commensals Induces a MyD88-Dependent, Pulmonary T-Helper Cell Type 17 Response that Mitigates Susceptibility to Streptococcus Pneumoniae

Wu, B. G., Sulaiman, I., Tsay, J.-C. J., Perez, L., Franca, B., Li, Y., Wang, J., Gonzalez, A. N., El-Ashmawy, M., Carpenito, J., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202005-1596oc · Cited by 136 · see citing works

Role of probiotics and prebiotics in immunomodulation

Yahfoufi, N., Mallet, J., Graham, É. A., & Matar, C. (2018) · Current Opinion in Food Science · doi:10.1016/j.cofs.2018.04.006 · Cited by 135 · see citing works

Segmented Filamentous Bacteria – Metabolism Meets Immunity

Hedblom, G. A., Reiland, H. A., Sylte, M. J., Johnson, T. J., & Baumler, D. J. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01991 · Cited by 135 · see citing works

The Gut Microbiome Regulates Psychological-Stress-Induced Inflammation

Xu, C., Lee, S. K., Zhang, D., & Frenette, P. S. (2020) · Immunity · doi:10.1016/j.immuni.2020.06.025 · Cited by 131 · see citing works

PTH induces bone loss via microbial-dependent expansion of intestinal TNF+ T cells and Th17 cells

Yu, M., Malik Tyagi, A., Li, J.-Y., Adams, J., Denning, T. L., Weitzmann, M. N., Jones, R. M., & Pacifici, R. (2020) · Nature Communications · doi:10.1038/s41467-019-14148-4 · Cited by 148 · see citing works

Perturbed Mucosal Immunity and Dysbiosis Accompany Clinical Disease in a Rat Model of Spondyloarthritis

Asquith, M. J., Stauffer, P., Davin, S., Mitchell, C., Lin, P., & Rosenbaum, J. T. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39681 · Cited by 131 · see citing works

The gut ecosystem and immune tolerance

Shao, T., Hsu, R., Rafizadeh, D. L., Wang, L., Bowlus, C. L., Kumar, N., Mishra, J., Timilsina, S., Ridgway, W. M., Gershwin, M. E., et al. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103114 · Cited by 136 · see citing works

Induction of Intestinal Th17 Cells by Flagellins From Segmented Filamentous Bacteria

Wang, Y., Yin, Y., Chen, X., Zhao, Y., Wu, Y., Li, Y., Wang, X., Chen, H., & Xiang, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02750 · Cited by 130 · see citing works

Microbiota and host immune responses: a love–hate relationship

Tomkovich, S., & Jobin, C. (2015) · Immunology · doi:10.1111/imm.12538 · Cited by 129 · see citing works

Gut Microbiota and Mucosal Immunity in the Neonate

Dzidic, M., Boix-Amorós, A., Selma‐Royo, M., Mira, Á., & Collado, M. C. (2018) · Medical Sciences · doi:10.3390/medsci6030056 · Cited by 130 · see citing works

Embracing the gut microbiota: the new frontier for inflammatory and infectious diseases

van den Elsen, L. W. J., Poyntz, H., Weyrich, L. S., Young, W., & Forbes‐Blom, E. (2017) · Clinical & Translational Immunology · doi:10.1038/cti.2016.91 · Cited by 127 · see citing works

Transforming growth factor β: a master regulator of the gut microbiota and immune cell interactions

Bauché, D., & Marie, J. C. (2017) · Clinical & Translational Immunology · doi:10.1038/cti.2017.9 · Cited by 126 · see citing works

T Cell Responses to the Microbiota

Ivanov, I. I., Tuganbaev, T., Skelly, A. N., & Honda, K. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101320-011829 · Cited by 128 · see citing works

Deciphering interactions between the gut microbiota and the immune system via microbial cultivation and minimal microbiomes

Clavel, T., Neto, J. C. G., Lagkouvardos, I., & Ramer‐Tait, A. E. (2017) · Immunological Reviews · doi:10.1111/imr.12578 · Cited by 125 · see citing works

A commensal bacterial product elicits and modulates migratory capacity of CD39+CD4 T regulatory subsets in the suppression of neuroinflammation

Wang, Y., Begum-Haque, S., Telesford, K. M., Ochoa‐Repáraz, J., Christy, M., Kasper, E. J., Kasper, D. L., Robson, S. C., & Kasper, L. H. (2014) · Gut Microbes · doi:10.4161/gmic.29797 · Cited by 123 · see citing works

Autoimmune host–microbiota interactions at barrier sites and beyond

Ruff, W. E., & Kriegel, M. A. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.02.006 · Cited by 122 · see citing works

Intestinal bacterial β-glucuronidase as a possible predictive biomarker of irinotecan-induced diarrhea severity

Chamseddine, A. N., Ducreux, M. P., Armand, J., Paolettí, X., Satar, T., Paci, A., & Mir, O. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.03.002 · Cited by 119 · see citing works

Pathogens, Commensal Symbionts, and Pathobionts: Discovery and Functional Effects on the Host

Hornef, M. W. (2015) · ILAR Journal · doi:10.1093/ilar/ilv007 · Cited by 121 · see citing works

Innate lymphoid cell function in the context of adaptive immunity

Bando, J. K., & Colonna, M. (2016) · Nature Immunology · doi:10.1038/ni.3484 · Cited by 118 · see citing works

Dysbiotic microbiota interactions in Crohn’s disease

Caparrós, E., Wiest, R., Scharl, M. M., Rogler, G., Gutiérrez, A., Yılmaz, B., Wawrzyniak, M., & Francés, R. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1949096 · Cited by 118 · see citing works

Aryl hydrocarbon receptor: Linking environment to immunity

Cella, M., & Colonna, M. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.10.002 · Cited by 119 · see citing works

Commensal microbiota regulates T cell fate decision in the gut

Furusawa, Y., Obata, Y., & Hase, K. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0455-3 · Cited by 114 · see citing works

Paneth cell α-defensins and enteric microbiota in health and disease

Nakamura, K., Sakuragi, N., Takakuwa, A., & Ayabe, T. (2015) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2015-019 · Cited by 118 · see citing works

The role of the gut and microbes in the pathogenesis of spondyloarthritis

Asquith, M. J., Elewaut, D. S., Lin, P., & Rosenbaum, J. T. (2014) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2014.10.018 · Cited by 114 · see citing works

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

Vasconcelos, A. R., dos Santos, N. B., Scavone, C., & Munhoz, C. D. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00033 · Cited by 112 · see citing works

Gut immune cell trafficking: inter-organ communication and immune-mediated inflammation

Zundler, S., Günther, C., Kremer, A. E., Zaiss, M. M., Rothhammer, V., & Neurath, M. F. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00663-1 · Cited by 108 · see citing works

Induction of immune responses by intestinal segmented filamentous bacteria

Pacáková, I. (2022) · Digital Repository (National Repository of Grey Literature)

Focused specificity of intestinal TH17 cells towards commensal bacterial antigens

Yang, Y., Torchinsky, M. B., Gobert, M., Xiong, H., Xu, M., Linehan, J. L., Alonzo, F., Ng, C., Chen, A., Lin, X., et al. (2014) · Nature · doi:10.1038/nature13279 · Cited by 520 · see citing works

Specific Microbiota-Induced Intestinal Th17 Differentiation Requires MHC Class II but Not GALT and Mesenteric Lymph Nodes

Geem, D., Contreras, O. M., McBride, M., Newberry, R. D., Koni, P. A., & Denning, T. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303167 · Cited by 50 · see citing works

The role of intestinal mononuclear phagocytes in control of mucosal T cell homeostasis

Panea, C. (2016) · doi:10.7916/d8b56jwd

Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature 510

Yang, Y., Torchinsky, M. B., Gobert, M., Xiong, H., Xu, M., Jonathan, L., Alonzo, F., III, Ng, C., Chen, R., Lin, X., et al. (2014)