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Error catastrophe and antiviral strategy
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Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
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“Selection in these systems thus does not act on the level of individual mutants, but rather on the entire quasi-species [8–10].”
From Towards open-ended evolution in self-replicating molecular systems (2017) · cites this paper as [10]
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“Indeed, increasing the mutation rate to precipitate an error catastrophe appears to be a practical anti-retroviral strategy (14–16).”
From The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA (2011) · cites this paper as [16]
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Metadata
- Authors
- Eigen, M.
- Affiliations
- Max Planck Society (DE)
- Corresponding author
- Eigen, Manfred
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-10-07
- Volume
- 99
- Issue
- 21
- Pages
- 13374-13376
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC129678
- OpenAlex
- W1981105411
- Cited by
- 339
- References
- 19
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 10 · 2019: 15 · 2018: 12 · 2017: 11 · 2016: 12 · 2015: 20 · 2014: 19 · 2013: 14 · 2012: 25
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Physical Sciences › Mathematics › Applied Mathematics › Mathematical and Theoretical Epidemiology and Ecology Models
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- error catastrophe, antiviral strategies, viral replication, error threshold, viral quasispecies
- MeSH terms
- Antiviral Agents, DNA Replication, Models, Biological, Mutation, Virus Replication, Viruses, Virus Physiological Phenomena
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