The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Error catastrophe and antiviral strategy
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Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
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“Selection in these systems thus does not act on the level of individual mutants, but rather on the entire quasi-species [8–10].”
From Towards open-ended evolution in self-replicating molecular systems (2017) · cites this paper as [10]
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“Indeed, increasing the mutation rate to precipitate an error catastrophe appears to be a practical anti-retroviral strategy (14–16).”
From The prebiotic evolutionary advantage of transferring genetic information from RNA to DNA (2011) · cites this paper as [16]
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Citations
Cites
Selforganization of matter and the evolution of biological macromolecules
Eigen, M. (1971) · Die Naturwissenschaften · doi:10.1007/bf00623322 · Cited by 3,788
Self-citationThe Hypercycle: A principle of natural self-organization
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Eigen, M., & Schuster, P. (1977) · Naturwissenschaften · doi:10.1007/bf00450633 · Cited by 1,752
Self-citationEigen, M., & Schuster, P. (1979) · doi:10.1007/978-3-642-67247-7 · Cited by 949
Self-citationRNA virus error catastrophe: Direct molecular test by using ribavirin
Crotty, S., Cameron, C. E., & Andino, R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111085598 · Cited by 844
The Hypercycle: A principle of natural self-organization Part B: The abstract hypercycle
Eigen, M., & Schuster, P. (1978) · Naturwissenschaften · doi:10.1007/bf00420631 · Cited by 702
Self-citationHamming, R. W. (1980) · Cited by 693
Eigen, M., McCaskill, J., & Schuster, P. (1988) · The Journal of Physical Chemistry · doi:10.1021/j100335a010 · Cited by 670
Self-citationOrigin and Evolution of Viruses
Holland, J. J., & Domingo, E. (1998) · Virus Genes · doi:10.1023/a:1007989407305 · Cited by 524
Lethal mutagenesis of HIV with mutagenic nucleoside analogs
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Research works printed but not linked: 4
- Kimura M. & Ohta T. (1971) Population Genetics (Princeton Univ. Press Princeton NJ).
- Eigen M., McCaskill, J. & Schuster, P. (1989) Adv. Chem. Phys.75,149-263.
- 10.1007/BF02460094 · DOI
- Gebinoga M. (1991) Ph.D. thesis (Technical University of Braunschweig Braunschweig Germany).
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Spectroscopic analysis and synthesis of nucleoside analogs for lethal mutagenesis
Silvestre, K. J. (2014) · DSpace@MIT (Massachusetts Institute of Technology)
Norovirus replication and attenuation
Thorne, L. (2013) · doi:10.25560/28691
Hofmann, W. P., Polta, A., Herrmann, E. M., Mihm, U., Kronenberger, B., Sonntag, T., Lohmann, V., Schönberger, B., Zeuzem, S., & Sarrazin, C. (2007)
Li, D.-F., Cao, T.-G., Geng, J.-P., Gu, J., An, H., & Zhan, Y. (2015) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2015.05.014
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Hart, G. R. (2017) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)
Hamelin, M. (2007) · Corpus Université Laval (Université Laval)
Wang, G., & Wu, Y. (2021) · Research Square · doi:10.21203/rs.3.rs-586083/v1
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Xu, Z. (2020) · doi:10.31219/osf.io/52bw3
Shulman, L. M. (2020) · Springer eBooks · doi:10.1007/978-1-4939-2493-6_839-3
Faculty Opinions recommendation of Examining the theory of error catastrophe.
Coen, D. (2006) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1029485.358460
Costa, L. G., & Eaton, D. L. (2005) · Wiley eBooks · doi:10.1002/0471758043.biblio
(2014) · Elsevier eBooks · doi:10.1016/b978-1-907568-42-8.50016-2
Non-catastrophic collapse of VEEV by lethal mutagenesisPreprint
Alejandro, B. S., Kim, E., Hwang, J. Y., Park, J. W., Smith, M. L., & Chung, D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.21.496950
Shulman, L. M. (2023) · Encyclopedia of sustainability science and technology series · doi:10.1007/978-1-0716-2463-0_839
Salazar‐Lindo, E., & Díaz, R. H. (2014) · Revista Peruana de Pediatría · doi:10.61651/rped.2014v67n3p170-177
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Domingo, E., & Perales, C. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15750-9.00087-2
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Lag-induced critical transitions to extinction in replicating systems: the τ -tipping mechanism
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Metadata
- Authors
- Eigen, M.
- Affiliations
- Max Planck Society (DE)
- Corresponding author
- Eigen, Manfred
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-10-07
- Volume
- 99
- Issue
- 21
- Pages
- 13374-13376
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC129678
- OpenAlex
- W1981105411
- Cited by
- 339
- References
- 19
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 13 · 2020: 10 · 2019: 15 · 2018: 12 · 2017: 11 · 2016: 12 · 2015: 20 · 2014: 19 · 2013: 14 · 2012: 25
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Physical Sciences › Mathematics › Applied Mathematics › Mathematical and Theoretical Epidemiology and Ecology Models
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- error catastrophe, antiviral strategies, viral replication, error threshold, viral quasispecies
- MeSH terms
- Antiviral Agents, DNA Replication, Models, Biological, Mutation, Virus Replication, Viruses, Virus Physiological Phenomena
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