Cited by 270T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

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CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly

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Haynes, Laura, Eaton, Sheri M., Burns, Eve M., Randall, Troy D., Swain, Susan L.·2003·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.2433717100PMC PMC299903

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Abstract

Age-related declines in immune function have an impact on both primary and memory responses. In this study, we have examined the ability of naive CD4 T cells from young and aged T cell receptor transgenic mice to establish functional memory. We found that memory cells generated from young CD4 T cells responded well to antigen, even a year after generation, whereas memory cells derived from CD4 T cells from aged mice responded poorly both ex vivo and in vivo . Memory cells generated from aged naive cells proliferate less, produce reduced levels of cytokines, and exhibit reduced cognate helper function, compared with memory cells generated by using young naive cells. These results indicate that it is the age of the naive T cell when it first encounters antigen, rather than the age when it reencounters antigen, that is critical for good memory CD4 T cell function.

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Additional file 4 of Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson’s disease patients in a two-year follow-up: a case control study
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Additional file 3 of Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson’s disease patients in a two-year follow-up: a case control study
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Additional file 1 of Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson’s disease patients in a two-year follow-up: a case control study
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Additional file 7 of Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson’s disease patients in a two-year follow-up: a case control study
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Additional file 6 of Increased Tc17 cell levels and imbalance of naïve/effector immune response in Parkinson’s disease patients in a two-year follow-up: a case control study
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Authors: Haynes, L., Eaton, S. M., Burns, E. M., Randall, T. D., & Swain, S. L.
Affiliations: Trudeau Institute (US)
ORCID: Haynes, Laura
Randall, Troy D.
Swain, Susan L.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2003-12
Volume: 100
Issue: 25
Pages: 15053-15058
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.2433717100
PMC: PMC299903
OpenAlex: W2091101346
Cited by: 270
References: 33
Citations by year: 2026: 7 · 2025: 6 · 2024: 5 · 2023: 10 · 2022: 9 · 2021: 27 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 14 · 2016: 10 · 2015: 7 · 2014: 9 · 2013: 22 · 2012: 9
FWCI: 2.80
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (P01AG021600, P01AG001743, R01AG021054, AG21054, AG-01743)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: CD4+ T cell memory, naive T cells, immunosenescence, aging, T cell receptor transgenic mice, cytokine production, T cell proliferation, helper functions
MeSH terms: Aging, Animals, Cell Line, Cell Separation, Flow Cytometry, Immunologic Memory, Interferon-gamma, Interleukin-2, Lymphocytes, Mice, Transgenic, Microscopy, Fluorescence, Phenotype, CD4-Positive T-Lymphocytes, Interleukin-4, Interleukin-5, Cytokines, Cell Culture Techniques, Mice

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CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly

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