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Cited by 270T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

CD4 T cell memory derived from young naive cells functions well into old age, but memory generated from aged naive cells functions poorly

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Haynes, Laura, Eaton, Sheri M., Burns, Eve M., Randall, Troy D., Swain, Susan L.·2003·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.2433717100PMC PMC299903
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Abstract

Age-related declines in immune function have an impact on both primary and memory responses. In this study, we have examined the ability of naive CD4 T cells from young and aged T cell receptor transgenic mice to establish functional memory. We found that memory cells generated from young CD4 T cells responded well to antigen, even a year after generation, whereas memory cells derived from CD4 T cells from aged mice responded poorly both ex vivo and in vivo . Memory cells generated from aged naive cells proliferate less, produce reduced levels of cytokines, and exhibit reduced cognate helper function, compared with memory cells generated by using young naive cells. These results indicate that it is the age of the naive T cell when it first encounters antigen, rather than the age when it reencounters antigen, that is critical for good memory CD4 T cell function.

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Crossref · 10.1073/pnas.2433717100

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Research works printed but not linked: 2

  1. Phair, J., Kauffman, A., Bjornson, A., Adams, L. & Linnemann, C. (1978) J. Lab. Clin. Med. 92, 822-828.309499
  2. Miller R. A. (1999) in Fundamental Immunology ed. Paul W. E. (Lippincott-Raven Publishers Philadelphia) pp. 947-966.

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Metadata

Authors
Haynes, L., Eaton, S. M., Burns, E. M., Randall, T. D., & Swain, S. L.
Affiliations
Trudeau Institute (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2003-12
Volume
100
Issue
25
Pages
15053-15058
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.2433717100
PMC
PMC299903
OpenAlex
W2091101346
Cited by
270
References
33
Citations by year
2026: 7 · 2025: 6 · 2024: 5 · 2023: 10 · 2022: 9 · 2021: 27 · 2020: 11 · 2019: 14 · 2018: 12 · 2017: 14 · 2016: 10 · 2015: 7 · 2014: 9 · 2013: 22 · 2012: 9
FWCI
2.80
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (P01AG021600, P01AG001743, R01AG021054, AG21054, AG-01743)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
CD4+ T cell memory, naive T cells, immunosenescence, aging, T cell receptor transgenic mice, cytokine production, T cell proliferation, helper functions
MeSH terms
Aging, Animals, Cell Line, Cell Separation, Flow Cytometry, Immunologic Memory, Interferon-gamma, Interleukin-2, Lymphocytes, Mice, Transgenic, Microscopy, Fluorescence, Phenotype, CD4-Positive T-Lymphocytes, Interleukin-4, Interleukin-5, Cytokines, Cell Culture Techniques, Mice

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