The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Ethanol enhances α 4 β 3 δ and α 6 β 3 δ γ-aminobutyric acid type A receptors at low concentrations known to affect humans
Open accessAbstract
γ-Aminobutyric acid type A receptors (GABARs) have long been implicated in mediating ethanol (EtOH) actions, but so far most of the reported recombinant GABAR combinations have shown EtOH responses only at fairly high concentrations (≥60 mM). We show that GABARs containing the δ-subunit, which are highly sensitive to γ-aminobutyric acid, slowly inactivating, and thought to be located outside of synapses, are enhanced by EtOH at concentrations that are reached with moderate, social EtOH consumption. Reproducible ethanol enhancements occur at 3 mM, a concentration six times lower than the legal blood-alcohol intoxication (driving) limit in most states (0.08% wt/vol or 17.4 mM). GABARs responsive to these low EtOH concentrations require the GABAR δ-subunit, which is thought to be associated exclusively with α 4 - and α 6 -subunits in vivo , and the β 3 -subunit, which has recently been shown to be essential for the in vivo anesthetic actions of etomidate and propofol. GABARs containing β 2 -instead of β 3 -subunits in α 4 βδ- and α 6 βδ-receptor combinations are almost 10 times less sensitive to EtOH, with threshold enhancement at 30 mM. GABARs containing γ 2 -instead of δ-subunits with α 4 β and α 6 β are three times less sensitive to EtOH, with threshold responses at 100 mM, a concentration not usually reached with social EtOH consumption. These combined findings suggest that “extrasynaptic” δ-subunit-containing GABARs, but not their “synaptic” γ-subunit-containing counterparts, are primary targets for EtOH.
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Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons
Lovinger, D. M., White, G., & Weight, F. F. (1989) · Science · doi:10.1126/science.2467382 · Cited by 1,448
Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors
Mihic, S. J., Ye, Q., Wick, M. J., Koltchine, V. V., Krasowski, M. D., Finn, S. E., Mascia, M. P., Valenzuela, C. F., Hanson, K. K., Greenblatt, E. P., et al. (1997) · Nature · doi:10.1038/38738 · Cited by 1,219
Nusser, Z., Sieghart, W., & Somogyi, P. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-05-01693.1998 · Cited by 833
Bridging the cleft at GABA synapses in the brain
Mody, I., De Koninck, Y., Otis, T. S., & Soltesz, I. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90155-4 · Cited by 620
Pharmacological characterization of a novel cell line expressing human α4β3δ GABAA receptors
Brown, N., Kerby, J., Bonnert, T. P., Whiting, P. J., & Wafford, K. A. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704795 · Cited by 603
Adaptive regulation of neuronal excitability by a voltage- independent potassium conductance
Brickley, S. G., Revilla, V., Cull-Candy, S. G., Wisden, W., & Farrant, M. (2001) · Nature · doi:10.1038/35051086 · Cited by 572
Jurd, R., Arrasa, M., Lambert, S., Drexler, B., Siegwart, R., Crestani, F., Zaugg, M., Vogt, K. E., Ledermann, B., Antkowiak, B., et al. (2003) · The FASEB Journal · doi:10.1096/fj.02-0611fje · Cited by 558
Suzdak, P. D., Schwartz, R. D., Skolnick, P., & Paul, S. M. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4071 · Cited by 539
Mihalek, R. M., Banerjee, P. K., Korpi, E. R., Quinlan, J. J., Firestone, L. L., Mi, Z.-P., Lagenaur, C., Tretter, V., Sieghart, W., Anagnostaras, S. G., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12905 · Cited by 520
Self-citationSelective Modulation of Tonic and Phasic Inhibitions in Dentate Gyrus Granule Cells
Nusser, Z., & Mody, I. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.87.5.2624 · Cited by 485
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Belelli, D., & Lambert, J. J. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1703 · Cited by 1,159
Olsen, R. W., & Sieghart, W. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.00505 · Cited by 1,064
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Metadata
- Authors
- Wallner, M., Hanchar, H. J., & Olsen, R. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-11-18
- Volume
- 100
- Issue
- 25
- Pages
- 15218-15223
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2032093027
- Cited by
- 462
- References
- 51
- FWCI
- 12.66
- Type
- journal article
- Language
- en
- Open access
- green
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