Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

Autophagy as a Regulated Pathway of Cellular Degradation

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TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

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Pten is essential for embryonic development and tumour suppression

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Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

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Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

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Molecular dissection of autophagy: two ubiquitin-like systems

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Protection against Fatal Sindbis Virus Encephalitis by Beclin, a Novel Bcl-2-Interacting Protein

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Beclin 1 expression predicts favorable clinical outcome in patients with diffuse large B-cell lymphoma treated with R-CHOP

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MUC1 oncoprotein promotes autophagy in a survival response to glucose deprivation

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Roles of Autophagy Induced by Natural Compounds in Prostate Cancer

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Modulation of Autophagy by Calcium Signalosome in Human Disease

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Expression patterns of the activator protein-1 (AP-1) family members in lymphoid neoplasms

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Resveratrol‐Mediated Downregulation of Rictor Attenuates Autophagic Process and Suppresses UV‐Induced Skin Carcinogenesis †

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Autophagy is active in normal colon mucosa

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Downregulation of Beclin1 and Impairment of Autophagy in a Small Population of Colorectal Cancer

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Mammalian Target of Rapamycin Signaling and Autophagy: Roles in Lymphangioleiomyomatosis Therapy

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BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development

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Nuclear localization of Beclin 1 promotes radiation-induced DNA damage repair independent of autophagy

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Autophagy and liver cancer

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Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

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Autophagy and mammalian development

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Why is autophagy important for melanoma? Molecular mechanisms and therapeutic implications

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Targeting autophagy in skin diseases

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Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy

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The Combination of RAD001 and MK-2206 Exerts Synergistic Cytotoxic Effects against PTEN Mutant Gastric Cancer Cells: Involvement of MAPK-Dependent Autophagic, but Not Apoptotic Cell Death Pathway

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Autophagy and Apoptotic Crosstalk: Mechanism of Therapeutic Resistance in HER2-Positive Breast Cancer

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Autophagy: from basic science to clinical application

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The Bright and the Dark Side of TGF-β Signaling in Hepatocellular Carcinoma: Mechanisms, Dysregulation, and Therapeutic Implications

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Impact of Complex Apoptotic Signaling Pathways on Cancer Cell Sensitivity to Therapy

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Absence of Autophagy-Related Proteins Expression Is Associated with Poor Prognosis in Patients with Colorectal Adenocarcinoma

Choi, J. H., Cho, Y., Ko, Y. H., Hong, S. U., Park, J. H., & Lee, M. A. (2014) · Gastroenterology Research and Practice · doi:10.1155/2014/179586 · Cited by 50

Patulin induces pro-survival functions via autophagy inhibition and p62 accumulation

Guo, X., Dong, Y., Yin, S., Zhao, C., Huo, Y., Fan, L., & Hu, H. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.349 · Cited by 51

Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture

Chen, N., Eritja, N., Lock, R., & Debnath, J. (2013) · Oncogene · doi:10.1038/onc.2012.277 · Cited by 50

Beclin 1 expression is an independent prognostic factor for gastric carcinomas

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Pathophysiological Role of Autophagy: Lesson from Autophagy-Deficient Mouse Models

Ichimura, Y., & Komatsu, M. (2011) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.60.329 · Cited by 50

Ginsenoside Rg1 inhibits angiotensin II‐induced podocyte autophagy via AMPK/mTOR/PI3K pathway

Mao, N., Tan, R., Wang, S., Wei, C., Shi, X., Fan, J., & Wang, L. (2016) · Cell Biology International · doi:10.1002/cbin.10634 · Cited by 50

Therapeutic Modulation of Autophagy in Leukaemia and Lymphoma

Djavaheri‐Mergny, M., Giuriato, S., Tschan, M. P., & Humbert, M. (2019) · Cells · doi:10.3390/cells8020103 · Cited by 52

Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide

Pang, D., Li, C., Yang, C., Zou, Y., Feng, B., Li, L., Liu, W., Geng, Y., Luo, Q., Chen, Z., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1805635 · Cited by 50

Tumor-intrinsic determinants of immunogenic cell death modalities

Workenhe, S. T., Pol, J. G., & Kroemer, G. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1893466 · Cited by 52

Autophagy Regulates Keratin 8 Homeostasis in Mammary Epithelial Cells and in Breast Tumors

Kongara, S., Kravchuk, O., Teplova, I., Lozy, F., Schulte, J., Moore, D. F., Barnard, N., Neumann, C. A., White, E., & Karantza, V. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0494 · Cited by 53

Identification of a lung cancer cell line deficient in atg7-dependent autophagy

Mandelbaum, J., Rollins, N., Shah, P., Bowman, D., Lee, J. Y., Tayber, O., Bernard, H., Leroy, P. J., Li, P., Koenig, E. M., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1056966 · Cited by 49

Alteration of Upstream Autophagy‐Related Proteins ( ULK1 , ULK2 , B eclin1, VPS34 and AMBRA1 ) in L ewy Body Disease

Miki, Y., Tanji, K., Mori, F., Utsumi, J., Sasaki, H., Kakita, A., Takahashi, H., & Wakabayashi, K. (2015) · Brain Pathology · doi:10.1111/bpa.12297 · Cited by 50

Connecting autophagy: AMBRA1 and its network of regulation

Cianfanelli, V., Nazio, F., & Cecconi, F. (2015) · Molecular & Cellular Oncology · doi:10.4161/23723548.2014.970059 · Cited by 49

E Platinum, a newly synthesized platinum compound, induces autophagy via inhibiting phosphorylation of mTOR in gastric carcinoma BGC-823 cells

Chen, H., Zou, M., Zhao, L., Lu, N., Sun, Y., Gou, S., Xi, T., & Guo, Q. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.01.019 · Cited by 49

The significance of expression of autophagy-related gene Beclin, Bcl-2, and Bax in breast cancer tissues

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Recent insights on the putative role of autophagy in autoimmune diseases

Gianchecchi, E., Delfino, D. V., & Fierabracci, A. (2013) · Autoimmunity Reviews · doi:10.1016/j.autrev.2013.10.007 · Cited by 50

Role of autophagy and its significance in cellular homeostasis

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Autophagy in C. elegans development

Palmisano, N. J., & Meléndez, A. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.04.009 · Cited by 53

Gambogic acid induces autophagy and combines synergistically with chloroquine to suppress pancreatic cancer by increasing the accumulation of reactive oxygen species

Wang, H., Zhao, Z., Lei, S., Li, S., Xiang, Z., Wang, X., Huang, X., Xia, G., & Huang, X. (2019) · Cancer Cell International · doi:10.1186/s12935-018-0705-x · Cited by 49

The Interplay of Autophagy and Tumor Microenvironment in Colorectal Cancer—Ways of Enhancing Immunotherapy Action

Koustas, E., Sarantis, P., Kyriakopoulou, G., Papavassiliou, A. G., & Karamouzis, M. V. (2019) · Cancers · doi:10.3390/cancers11040533 · Cited by 50

Jun Proteins Are Starvation-Regulated Inhibitors of Autophagy

Yogev, O., Goldberg, R. L., Anzi, S., Yogev, O., & Shaulian, E. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-3408 · Cited by 52

A ratiometric fluorescent probe for monitoring pH fluctuations during autophagy in living cells

Wang, S., Wang, B., Zhu, L., Hou, J., & Yu, K. (2021) · Chemical Communications · doi:10.1039/d0cc07788g · Cited by 49

Autophagy regulation by RNA alternative splicing and implications in human diseases

González-Rodríguez, P., Klionsky, D. J., & Joseph, B. (2022) · Nature Communications · doi:10.1038/s41467-022-30433-1 · Cited by 49

LITAF , a BCL 6 target gene, regulates autophagy in mature B‐cell lymphomas

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Interaction between Her2 and Beclin-1 Proteins Underlies a New Mechanism of Reciprocal Regulation

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Serum deprivation induced autophagy and predominantly an AIF-dependent apoptosis in hippocampal HT22 neurons

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Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia

Tong, Y., You, L., Liu, H., Li, L., Meng, H., Qian, Q., & Qian, W. (2013) · Oncotarget · doi:10.18632/oncotarget.1018 · Cited by 49

Spatial expression patterns of autophagy genes in the eye lens and induction of autophagy in lens cells.

Brennan, L., Kantorow, W. L., Chauss, D., McGreal, R., He, S., Mattucci, L., Wei, J., Riazuddin, S., Cvekl, A., Hejtmancik, J. F., et al. (2012) · Europe PMC (PubMed Central) · Cited by 50

Thapsigargin induces apoptosis when autophagy is inhibited in HepG2 cells and both processes are regulated by ROS-dependent pathway

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Relevance of autophagy to fatty liver diseases and potential therapeutic applications

Yan, S., Huda, N., Khambu, B., & Yin, X. (2017) · Amino Acids · doi:10.1007/s00726-017-2429-y · Cited by 47

Quantitative and qualitative analysis of autophagy flux using imaging

Kim, S., Choi, S., & Kang, D. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.5.046 · Cited by 47

The role of FOXOs and autophagy in cancer and metastasis—Implications in therapeutic development

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Deciphering functional roles and interplay between Beclin1 and Beclin2 in autophagosome formation and mitophagy

Quiles, J. M., Najor, R. H., Gonzalez, E. R., Jeung, M., Liang, W., Burbach, S. M., Zumaya, E. A., Diao, R. Y., Lampert, M. A., & Gustafsson, Å. B. (2023) · Science Signaling · doi:10.1126/scisignal.abo4457 · Cited by 49

Retinoid receptor signaling and autophagy in acute promyelocytic leukemia

Orfali, N., McKenna, S. L., Cahill, M. R., Gudas, L. J., & Mongan, N. P. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.03.018 · Cited by 47

Shikonin promotes autophagy in BXPC-3 human pancreatic cancer cells through the PI3K/Akt signaling pathway

Shi, S., & CAO, H. (2014) · Oncology Letters · doi:10.3892/ol.2014.2293 · Cited by 47

Neuroinflammation and neuronal autophagic death were suppressed via Rosiglitazone treatment: New evidence on neuroprotection in a rat model of global cerebral ischemia

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Galangin suppresses HepG2 cell proliferation by activating the TGF-β receptor/Smad pathway

Wang, Y., Wu, J., Lin, B., Li, X., Zhang, H., Ding, H., Chen, X., Lan, L., & Luo, H. (2014) · Toxicology · doi:10.1016/j.tox.2014.09.010 · Cited by 46

Fas-mediated autophagy requires JNK activation in HeLa cells

Zhang, Y., Wu, Y., Cheng, Y., Zhao, Z., Tashiro, S., Onodera, S., & Ikejima, T. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.151 · Cited by 47

STAT3 as a new autophagy regulator

Jonchère, B., Bélanger, A., Guette, C., Barré, B., & Coqueret, O. (2013) · JAK-STAT · doi:10.4161/jkst.24353 · Cited by 48

Interplay between apoptosis and autophagy, a challenging puzzle: New perspectives on antitumor chemotherapies

Bincoletto, C., Bechara, A., Pereira, G. J. S., Santos, C. P., Antunes, F., Peixoto-da-Silva, J., Muler, M. L., Gigli, R. D., Monteforte, P. T., Hirata, H., et al. (2013) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2013.09.018 · Cited by 47

Autophagy in cancer: Having your cake and eating it

Hoare, M., Young, A. R. J., & Narita, M. (2011) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.09.004 · Cited by 47

Autophagy is involved in regulating the immune response of dendritic cells to influenza A (H1N1) pdm09 infection

Zang, F., Chen, Y., Lin, Z., Cai, Z., Yu, L., Xu, F., Wang, J., Zhu, W., & Lu, H. (2016) · Immunology · doi:10.1111/imm.12587 · Cited by 47

The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases?

García-Huerta, P., Troncoso-Escudero, P., Jerez, C., Hetz, C. A., & Vidal, R. L. (2016) · Brain Research · doi:10.1016/j.brainres.2016.02.052 · Cited by 48

Growth inhibitory effect of paratocarpin E, a prenylated chalcone isolated from Euphorbia humifusa Wild., by induction of autophagy and apoptosis in human breast cancer cells

Gao, S., Sun, D., Wang, G., Zhang, J. C., Jiang, Y., Li, G., Zhang, K., Wang, L., Huang, J. M., & Chen, L. (2016) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2016.10.005 · Cited by 47

Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity

Xia, J., Dai, L., Wang, L., & Zhu, J. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.108932 · Cited by 47

Regulation of Beclin 1-Mediated Autophagy by Oncogenic Tyrosine Kinases

Vega-Rubín-de-Celis, S., Kinch, L. N., & Peña‐Llopis, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239210 · Cited by 48

Enzymes in the Cholesterol Synthesis Pathway: Interactomics in the Cancer Context

Ershov, P., Kaluzhskiy, L. A., Mezentsev, Y. V., Yablokov, E. O., Gnedenko, O. V., & Ivanov, A. S. (2021) · Biomedicines · doi:10.3390/biomedicines9080895 · Cited by 48

Mitochondrial quality surveillance: mitophagy in cardiovascular health and disease

Diao, R. Y., & Gustafsson, Å. B. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00360.2021 · Cited by 50

Autophagy-related Proteins as a Prognostic Factor of Patients With Colorectal Cancer

Koustas, E., Sarantis, P., Theoharis, S., Saetta, A. A., Chatziandreou, I., Kyriakopoulou, G., Giannopoulou, I., Michelli, M., Schizas, D., Papavassiliou, A. G., et al. (2019) · American Journal of Clinical Oncology · doi:10.1097/coc.0000000000000592 · Cited by 44

Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors

Lashinger, L. M., O’Flanagan, C. H., Dunlap, S. M., Rasmussen, A. J., Sweeney, S., Guo, J. Y., Lodi, A., Tiziani, S., White, E., & Hursting, S. D. (2016) · Cancer & Metabolism · doi:10.1186/s40170-016-0158-4 · Cited by 48

Dysfunctional adipocytes promote tumor progression through YAP/TAZ-dependent cancer-associated adipocyte transformation

Song, Y., Na, H., Lee, S. E., Kim, Y. M., Moon, J., Nam, T. W., Ji, Y., Jin, Y., Park, J. H., Cho, S. C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48179-3 · Cited by 46

Antitumor Effects of Rapamycin in Pancreatic Cancer Cells by Inducing Apoptosis and Autophagy

Dai, Z.-J., Gao, J., Ma, X., Kang, H., Wang, B., Lu, W.-F., Lin, S., Wang, X.-J., & Wu, W. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms14010273 · Cited by 49

Receptor Signaling Lymphocyte-activation Molecule Family 1 (Slamf1) Regulates Membrane Fusion and NADPH Oxidase 2 (NOX2) Activity by Recruiting a Beclin-1/Vps34/Ultraviolet Radiation Resistance-associated Gene (UVRAG) Complex

Ma, C., Wang, N., Detre, C., Wang, G., O’Keeffe, M. S., & Terhorst, C. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.367060 · Cited by 46

Mitochondria of highly metastatic breast cancer cell line MDA-MB-231 exhibits increased autophagic properties

Tu, Y., Kaipparettu, B. A., Ma, Y., & Wong, L.-J. C. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.04.015 · Cited by 48

Autophagy-associated Targeting Pathways of Natural Products during Cancer Treatment

Zhang, S., Wang, X., Yang, X., & Chen, N. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2014.15.24.10557 · Cited by 46

Decreased expression of Beclin 1 correlates with a metastatic phenotypic feature and adverse prognosis of gastric carcinomas

Chen, Y., Hou, J.-H., Feng, X., Chen, S., Zhou, Z., Zhang, X.-S., & Cai, M. (2011) · Journal of Surgical Oncology · doi:10.1002/jso.22151 · Cited by 46

Autophagy-based survival prognosis in human colorectal carcinoma

Yang, M., Zhao, H., Guo, L., Zhang, Q., Zhao, L., Bai, S., Zhang, M., Xu, S., Wang, F., Wang, X., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3054 · Cited by 47

MicroRNA-106a targets autophagy and enhances sensitivity of lung cancer cells to Src inhibitors

Rothschild, S. I., Gautschi, O. P., Batliner, J., Gugger, M., Fey, M. F., & Tschan, M. P. (2016) · Lung Cancer · doi:10.1016/j.lungcan.2016.06.004 · Cited by 47

Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction

Ghanta, S., Tsoyi, K., Liu, X., Nakahira, K., Ith, B., Coronata, A. A., Fredenburgh, L. E., Englert, J. A., Piantadosi, C. A., Choi, A. M. K., et al. (2016) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0061oc · Cited by 47

The Role of Large Neutral Amino Acid Transporter (LAT1) in Cancer

Lu, X. (2019) · Current Cancer Drug Targets · doi:10.2174/1568009619666190802135714 · Cited by 46

PTEN/AKT/mTOR pathway involvement in autophagy, mediated by miR-99a-3p and energy metabolism in ammonia-exposed chicken bursal lymphocytes

Shah, S. W. A., Zhang, S., Ishfaq, M., Tang, Y., & Teng, X. (2020) · Poultry Science · doi:10.1016/j.psj.2020.11.015 · Cited by 44

Emerging Roles of Impaired Autophagy in Fatty Liver Disease and Hepatocellular Carcinoma

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The pleiotropic functions of autophagy in metastasis

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