Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

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Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress

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Early etiology of Alzheimer’s disease: tipping the balance toward autophagy or endosomal dysfunction?

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Integrating stress signals at the endoplasmic reticulum: The BCL-2 protein family rheostat

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The Role of AKT/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and Senescence

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Presynaptic Terminals Independently Regulate Synaptic Clustering and Autophagy of GABAAReceptors in Caenorhabditis elegans

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MIR181Aregulates starvation- and rapamycin-induced autophagy through targeting ofATG5

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Structure of the Human Autophagy Initiating Kinase ULK1 in Complex with Potent Inhibitors

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Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress

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Diet, Autophagy, and Cancer: A Review

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Calpain is required for macroautophagy in mammalian cells

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Neuronal macroautophagy: From development to degeneration

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New Insights into the Mechanisms of Macroautophagy in Mammalian Cells

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The role of autophagy in hepatocellular carcinoma: friend or foe

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Initiation of apoptosis and autophagy by photodynamic therapy

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Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic myeloid leukemia

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Autophagy—A double‐edged sword in oncology

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Autophagy as a target for cancer therapy: new developments

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Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity

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Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability

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The role of autophagy induced by tumor microenvironment in different cells and stages of cancer

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Prognostic impact of Beclin 1, p62/sequestosome 1 and LC3 protein expression in colon carcinomas from patients receiving 5-fluorouracil as adjuvant chemotherapy

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Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment

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Autophagic control of cell ‘stemness’

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Autophagy: More Than a Nonselective Pathway

Reggiori, F., Komatsu, M., Finley, K. D., & Simonsen, A. (2012) · International Journal of Cell Biology · doi:10.1155/2012/219625 · Cited by 161

Autophagy Signaling and the Cogwheels of Cancer

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Autophagy protects the retina from light-induced degeneration

Chen, Y., Sawada, O., Kohno, H., Le, Y.-Z., Subauste, C., Maeda, T., & Maeda, A. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.439935 · Cited by 152

Therapeutic Targeting of Autophagy

Orogo, A. M., & Gustafsson, Å. B. (2015) · Circulation Research · doi:10.1161/circresaha.116.303791 · Cited by 157

Programmed Cell Death Pathways and Current Antitumor Targets

Tan, M., Ooi, J. P., Ismail, N. I., Moad, A. I. H., & Muhammad, T. S. T. (2009) · Pharmaceutical Research · doi:10.1007/s11095-009-9895-1 · Cited by 156

Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells

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Following Cytochrome c Release, Autophagy Is Inhibited during Chemotherapy-Induced Apoptosis by Caspase 8–Mediated Cleavage of Beclin 1

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Autophagy in kidney disease and aging: lessons from rodent models

Lenoir, O., Tharaux, P., & Huber, T. B. (2016) · Kidney International · doi:10.1016/j.kint.2016.04.014 · Cited by 156

ATM‐CHK2‐Beclin 1 axis promotes autophagy to maintain ROS homeostasis under oxidative stress

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Autophagy: a multifaceted player in the fate of sperm

Wang, M., Zeng, L., Su, P., Ma, L., Zhang, M., & Zhang, Y. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab043 · Cited by 155

NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity

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Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness

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Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy

Peraro, L., Zou, Z., Makwana, K. M., Cummings, A. E., Ball, H. L., Yu, H., Lin, Y., Levine, B., & Kritzer, J. A. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b01698 · Cited by 148

Autophagy

Kelekar, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1363.015 · Cited by 152

Autophagy and the degradation of mitochondria

Goldman, S. J., Taylor, R., Zhang, Y., & Jin, S. V. (2010) · Mitochondrion · doi:10.1016/j.mito.2010.01.005 · Cited by 147

Bif-1/Endophilin B1: a candidate for crescent driving force in autophagy

Takahashi, Y., Meyerkord, C. L., & Wang, H.-G. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.19 · Cited by 151

Heat Shock Factor 1 (HSF1) Controls Chemoresistance and Autophagy through Transcriptional Regulation of Autophagy-related Protein 7 (ATG7)

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Autophagy as a therapeutic target for ischaemia /reperfusion injury? Concepts, controversies, and challenges

Przyklenk, K., Dong, Y., Undyala, V. V. R., & Whittaker, P. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvr358 · Cited by 149

Glutaminolysis and autophagy in cancer

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The cell biology of autophagy in metazoans: a developing story

Meléndez, A., & Neufeld, T. P. (2008) · Development · doi:10.1242/dev.016105 · Cited by 145

Autophagy in Stem Cell Maintenance and Differentiation

Vessoni, A. T., Muotri, A. R., & Okamoto, O. K. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0526 · Cited by 146

Macroautophagy in CNS health and disease

Griffey, C. J., & Yamamoto, A. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00588-3 · Cited by 147

Elongation Factor-2 Kinase Regulates Autophagy in Human Glioblastoma Cells

Wu, H., Yang, J., Jin, S., Zhang, H., & Hait, W. N. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1554 · Cited by 146

VPS34 complexes from a structural perspective

Ohashi, Y., Tremel, S., & Williams, R. L. (2019) · Journal of Lipid Research · doi:10.1194/jlr.r089490 · Cited by 147

Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors

Huang, X., Bai, H., Chen, L., Li, B., & Lu, Y. (2010) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2010.03.051 · Cited by 145

Conversation between apoptosis and autophagy: “Is it your turn or mine?”

Giansanti, V., Torriglia, A., & Scovassi, A. I. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0589-x · Cited by 147

Self‐Assembled Autophagy‐Inducing Polymeric Nanoparticles for Breast Cancer Interference In‐Vivo

Wang, Y., Lin, Y., Qiao, Z., An, H., Qiao, S., Wang, L., Rajapaksha, R. P. Y. J., & Wang, H. (2015) · Advanced Materials · doi:10.1002/adma.201405926 · Cited by 141

Suppression of autophagy is protective in high glucose-induced cardiomyocyte injury

Kobayashi, S., Xu, X., Chen, K., & Liang, Q. (2012) · Autophagy · doi:10.4161/auto.18980 · Cited by 142

Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions

Miracco, C., Cevenini, G., Franchi, A., Luzi, P., Cosci, E., Mourmouras, V., Monciatti, I., Mannucci, S., Biagioli, M., Toscano, M., et al. (2010) · Human Pathology · doi:10.1016/j.humpath.2009.09.004 · Cited by 139

Cell “Self‐Eating” (Autophagy) Mechanism in Alzheimer's Disease

Funderburk, S. F., Marcellino, B. K., & Yue, Z. (2010) · Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20161 · Cited by 139

Autophagy: Emerging roles in lipid homeostasis and metabolic control

Christian, P., Sacco, J., & Adeli, K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2012.12.009 · Cited by 139

Life, death and burial: multifaceted impact of autophagy

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Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms

Kumar, D., Shankar, S., & Srivastava, R. K. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-171 · Cited by 141

Role of Autophagy in Breast Cancer

Karantza, V., & White, E. (2007) · Autophagy · doi:10.4161/auto.4867 · Cited by 141

Autophagy modulation for cancer therapy

Yang, Z. J., Chee, C. E., Huang, S., & Sinicrope, F. A. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.11.2.14663 · Cited by 140

Autophagy and Tumorigenesis

Roy, S., & Debnath, J. (2010) · Seminars in Immunopathology · doi:10.1007/s00281-010-0213-0 · Cited by 146

Autophagy and cancer: Modulation of cell death pathways and cancer cell adaptations

Towers, C. G., Wodetzki, D., & Thorburn, A. M. (2019) · The Journal of Cell Biology · doi:10.1083/jcb.201909033 · Cited by 142

The autophagic response to nutrient deprivation in the hl‐1 cardiac myocyte is modulated by Bcl‐2 and sarco/endoplasmic reticulum calcium stores

Brady, N. R., Hamacher‐Brady, A., Yuan, H., & Gottlieb, R. A. (2007) · The FEBS Journal · doi:10.1111/j.1742-4658.2007.05849.x · Cited by 137

Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells

Zeng, M., & Zhou, J. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.11.015 · Cited by 137

Prognostic significance of p62/SQSTM1 subcellular localization and LC3B in oral squamous cell carcinoma

Jl, L., Chen, F.-F., Lung, J., Lo, C.-H., Lee, F., Lu, Y.-C., & Hung, C. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.355 · Cited by 139

Synthesis and screening of 3-MA derivatives for autophagy inhibitors

Wu, Y., Wang, X., Guo, H., Zhang, B., Zhang, X.-B., Shi, Z., & Yu, L. (2013) · Autophagy · doi:10.4161/auto.23641 · Cited by 134

XIAP inhibits autophagy via XIAP‐Mdm2‐p53 signalling

Huang, X., Wu, Z., Mei, Y., & Wu, M. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.133 · Cited by 138

Autophagy and Cancer Metabolism

Goldsmith, J., Levine, B., & Debnath, J. (2014) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-416618-9.00002-9 · Cited by 139

Cadmium induces autophagy through ROS-dependent activation of the LKB1–AMPK signaling in skin epidermal cells

Son, Y., Wang, X., Hitron, J. A., Zhang, Z., Cheng, S., Budhraja, A., Ding, S., Lee, J., & Shi, X. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.06.024 · Cited by 136

Autophagy is essential to suppress cell stress and to allow BCR-Abl-mediated leukemogenesis

Altman, B. J., Jacobs, S., Mason, E. F., Michalek, R. D., Macintyre, A. N., Coloff, J. L., Ilkayeva, O., Jia, W. P., He, Y.-W., & Rathmell, J. C. (2010) · Oncogene · doi:10.1038/onc.2010.561 · Cited by 140

Arabidopsis AtBECLIN 1/AtAtg6/AtVps30 is essential for pollen germination and plant development

Qin, G., Ma, Z., Zhang, L., Xing, S., Hou, X., Deng, J., Liu, J., Chen, Z., Qu, L., & Gu, H. (2007) · Cell Research · doi:10.1038/cr.2007.7 · Cited by 137

Spinal cord injury induces upregulation of Beclin 1 and promotes autophagic cell death

Kanno, H., Ozawa, H., Sekiguchi, A., & Itoi, E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.09.009 · Cited by 135

Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex

McKnight, N. C., Zhong, Y., Wold, M. S., Gong, S., Phillips, G. R., Dou, Z., Zhao, Y., Heintz, N., Zong, W.-X., & Yue, Z. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004626 · Cited by 136

Glioblastoma, hypoxia and autophagy: a survival-prone ‘ménage-à-trois’

Jawhari, S., Ratinaud, M., & Verdier, M. (2016) · Cell Death and Disease · doi:10.1038/cddis.2016.318 · Cited by 138

Teaching the basics of autophagy and mitophagy to redox biologists—Mechanisms and experimental approaches

Zhang, J. (2015) · Redox Biology · doi:10.1016/j.redox.2015.01.003 · Cited by 141

Genetic and epigenetic silencing of the beclin 1gene in sporadic breast tumors

Li, Z., Chen, B., Wu, Y., Jin, F., Xia, Y., & Liu, X. (2010) · BMC Cancer · doi:10.1186/1471-2407-10-98 · Cited by 140

Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2 -Associated Hereditary Breast Cancer

Huo, Y., Cai, H., Teplova, I., Bowman-Colin, C., Chen, G., Price, S. M., Barnard, N., Ganesan, S., Karantza, V., White, E., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0011 · Cited by 135

Molecular targets of celastrol in cancer: Recent trends and advancements

Kashyap, D., Sharma, A. K., Tuli, H. S., Sak, K., Mukherjee, T. K., & Bishayee, A. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.05.019 · Cited by 132

Antitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy

Zhang, J. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i34.4281 · Cited by 130

Differential Effects of TBC1D15 and Mammalian Vps39 on Rab7 Activation State, Lysosomal Morphology, and Growth Factor Dependence

Peralta, E. R., Martin, B. C., & Edinger, A. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.111633 · Cited by 132

Mitochondrial autophagy in neural function, neurodegenerative disease, neuron cell death, and aging

Batlevi, Y., & Spada, A. R. L. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.09.009 · Cited by 137

Different ways to die: cell death modes of the unicellular chlorophyte Dunaliella viridis exposed to various environmental stresses are mediated by the caspase-like activity DEVDase

Jiménez, C., Capasso, J. M., Edelstein, C. L., Rivard, C. J., Lucia, S., Breusegem, S. Y., Berl, T., & Segovia, M. (2009) · Journal of Experimental Botany · doi:10.1093/jxb/ern330 · Cited by 131

The natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation

Lao, Y., Wan, G., Liu, Z., Wang, X., Ruan, P., Xu, W., Xu, D., Xie, W., Zhang, Y., Xu, H., et al. (2014) · Autophagy · doi:10.4161/auto.28034 · Cited by 130

Autophagy - An Emerging Anti-Aging Mechanism?

Hansen, M. (2012) · Journal of Clinical & Experimental Pathology · doi:10.4172/2161-0681.s4-006 · Cited by 131

Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer: A review

Hector, S., & Prehn, J. H. M. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.12.002 · Cited by 128

JNK protects Drosophila from oxidative stress by trancriptionally activating autophagy

Wu, H., Wang, M. C., & Bohmann, D. (2009) · Mechanisms of Development · doi:10.1016/j.mod.2009.06.1082 · Cited by 134

Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance

Salem, A. F., Whitaker‐Menezes, D., Howell, A., Sotgia, F., & Lisanti, M. P. (2012) · Cell Cycle · doi:10.4161/cc.22376 · Cited by 131

The Bcl-2 Homology Domain 3 Mimetic Gossypol Induces Both Beclin 1-dependent and Beclin 1-independent Cytoprotective Autophagy in Cancer Cells

Gao, P., Bauvy, C., Souquère, S., Tonelli, G., Liu, L., Zhu, Y., Qiao, Z., Bakula, D., Proikas‐Cezanne, T., Pierron, G., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.118125 · Cited by 132

Activation of p62/SQSTM1–Keap1–Nuclear Factor Erythroid 2-Related Factor 2 Pathway in Cancer

Ichimura, Y., & Komatsu, M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00210 · Cited by 132

Ceramide induced mitophagy and tumor suppression

Dany, M., & Öğretmen, B. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.12.039 · Cited by 130

Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor Prognosis

Tang, H., Sebti, S., Titone, R., Zhou, Y., Isidoro, C., Ross, T. S., Hibshoosh, H. H., Xiao, G., Packer, M., Xie, Y., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.01.008 · Cited by 131

Is targeting autophagy mechanism in cancer a good approach? The possible double-edge sword effect

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