The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Evolution of human longevity and the genetic complexity governing aging rate.
Open accessAbstract
Genetic complexity of processes governing the aging rate of man was estimated by determining the maximum rate lifespan has evolved along the hominid ancestral-descendant sequence. Maximum lifespan potential was found to have increased approximately 2-fold over the past 3 million years, reaching a maximum rate of increase of 14 years per 100,000 years about 100,000 years ago. It is estimated that about 0.6% of the total functional genes have received substitutions leading to one or more adaptive amino acid changes during this 100,000-year time-period. This suggests that aging is not the result of an expression of a large number of independently acting processes. Instead, primary aging processes appear to exist where only a few genetic changes are necessary to decrease uniformly the aging rate of many different physiological functions.
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Cites
King, M.-C., & Wilson, A. C. (1975) · Science · doi:10.1126/science.1090005 · Cited by 2,815
Pilbeam, D., & Gould, S. J. (1974) · Science · doi:10.1126/science.186.4167.892 · Cited by 416
On the constancy of the evolutionary rate of cistrons
Ohta, T., & Kimura, M. (1971) · Journal of Molecular Evolution · doi:10.1007/bf01659391 · Cited by 322
On the rate of molecular evolution
Kimura, M., & Ohta, T. (1971) · Journal of Molecular Evolution · doi:10.1007/bf01659390 · Cited by 195
Cited by
Understanding the odd science of aging
Kirkwood, T. B. L. (2005) · Cell · doi:10.1016/j.cell.2005.01.027 · Cited by 1,984
Age Influence on the Immune System
Makinodan, T., & Kay, M. M. B. (1980) · Advances in Immunology · doi:10.1016/s0065-2776(08)60047-4 · Cited by 699
Longevity Among Hunter‐ Gatherers: A Cross‐Cultural Examination
Gurven, M., & Kaplan, H. (2007) · Population and Development Review · doi:10.1111/j.1728-4457.2007.00171.x · Cited by 670
Bocquet-Appel, J.-P., & Masset, C. (1982) · Journal of Human Evolution · doi:10.1016/s0047-2484(82)80023-7 · Cited by 549
Energy metabolism, brain size and longevity in mammals.
Hofman, M. A. (1983) · The Quarterly Review of Biology · doi:10.1086/413544 · Cited by 241
Metadata
- Authors
- Cutler, R. G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1975-11
- Volume
- 72
- Issue
- 11
- Pages
- 4664-4668
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1868818619
- Cited by
- 186
- References
- 4
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
