The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Abnormal oxidative metabolism of estradiol in women with breast cancer.
Open accessAbstract
The three dominant oxidative biotransformations of estradiol were examined in 10 normal women and 33 females with breast cancer by using a recently devised radiometric method. Estradiol tracers, labeled with 3H specifically in the 17 alpha, C-2, or 16 alpha position, were used to measure both the rate and extent of 17 beta-ol oxidation (the initial metabolic step) and the subsequent 2- and 16 alpha-oxidative reactions. The mean +/- SEM values for the extent of extradiol metabolism at these three specific sites for the extent of estradiol metabolism at these three specific sites were 76.9 +/- 5.3%, 31.1 +/- 4.0%, and 9.3 +/- 0.8%, respectively in normal subjects. Corresponding data in patients with breast cancer--i.e., 73.0 +/- 4.2%, 32.7 +/- 2.7%, and 14.9 +/- 1.5%--revealed a significantly greater extent of 16 alpha-hydroxylation in the latter population. Because the 16 alpha-hydroxylated compounds (including estriol) are themselves potent estrogens, these changes may have important hyperestrogenic consequences that could have a bearing on the etiology of the disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Etiology of Human Breast Cancer: A Review2
MacMahon, B., Cole, P., & Brown, J. (1973) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/50.1.21 · Cited by 769
Cancer of the Breast: The Past Decade
Henderson, I. C., & Canellos, G. P. (1980) · New England Journal of Medicine · doi:10.1056/nejm198001033020104 · Cited by 467
THE MEASUREMENT OF TOTAL BODY WATER IN THE HUMAN SUBJECT BY DEUTERIUM OXIDE DILUTION
Schloerb, P. R., Friis-Hansen, B. J., Edelman, I. S., Solomon, A. K., & Moore, F. D. (1950) · Journal of Clinical Investigation · doi:10.1172/jci102366 · Cited by 411
Changing Incidence of Breast Cancer in Japanese-American Women2
Buell, P. (1973) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/51.5.1479 · Cited by 371
CLARK, J. H., PASZKO, Z., & PECK, E. J. (1977) · Endocrinology · doi:10.1210/endo-100-1-91 · Cited by 243
FISHMAN, J., & MARTUCCI, C. (1980) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-51-3-611 · Cited by 215
Self-citationIncreased 16α-Hydroxylation of Estradiol in Systemic Lupus Erythematosus*
LAHITA, R. G., BRADLOW, H. L., KUNKEL, H. G., & FISHMAN, J. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-1-174 · Cited by 203
Self-citationMartucci, C. P., & Fishman, J. (1977) · Endocrinology · doi:10.1210/endo-101-6-1709 · Cited by 133
Self-citationOxidative Metabolism of Estradiol
Fishman, J., Bradlow, H. L., & Gallagher, T. F. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)81317-9 · Cited by 117
Self-citationUrine œstrogen profiles OF Asian and North American women
MacMahon, B., Cole, P. T., Brown, J. B., Aoki, K., Lin, T., Morgan, R. W., & Woo, N. (1974) · International Journal of Cancer · doi:10.1002/ijc.2910140204 · Cited by 116
Cited by
Health effects of vegetables and fruit: assessing mechanisms of action in human experimental studies
Lampe, J. W. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.3.475s · Cited by 786
17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.
Hayes, C. L., Spink, D. C., Spink, B. C., Cao, J. Q., Walker, N. J., & Sutter, T. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9776 · Cited by 632
Cytochrome P450-mediated metabolism of estrogens and its regulation in human
Tsuchiya, Y., Nakajima, M., & Yokoi, T. (2005) · Cancer Letters · doi:10.1016/j.canlet.2004.10.007 · Cited by 616
Endocrine disruptors and human health--is there a problem? An update.
Safe, S. H. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108487 · Cited by 351
Stanczyk, F. Z., Archer, D. F., & Bhavnani, B. R. (2013) · Contraception · doi:10.1016/j.contraception.2012.12.011 · Cited by 201
Metadata
- Authors
- Schneider, J., Kinne, D., Fracchia, A., Pierce, V, Anderson, K. E., Bradlow, H. L., & Fishman, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1982-05
- Volume
- 79
- Issue
- 9
- Pages
- 3047-3051
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1990862723
- Cited by
- 254
- References
- 23
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Abnormal oxidative metabolism of estradiol in women with breast cancer. https://app.cochat.ai/papers/10.1073/pnas.79.9.3047
- The paper
- Schneider, J., Kinne, D., Fracchia, A., Pierce, V, Anderson, K. E., Bradlow, H. L., & Fishman, J. (1982). Abnormal oxidative metabolism of estradiol in women with breast cancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.79.9.3047
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
