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Cited by 376

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets.

Elshourbagy, N A, Liao, W S, Mahley, R W, Taylor, J M·1985·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.82.1.203
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Abstract

The relative amount of apolipoprotein (apo-) E mRNA in 12 different tissues of the rat and marmoset was examined by dot blot hybridization using cloned cDNA probes. As expected, it was found to be most abundant in the liver. However, substantial amounts of apo-E mRNA were found in the brain and adrenals at relative levels about one-third of that found in the liver. Significant quantities of apo-E mRNA were detected in all of the other peripheral tissues as well. The apo-E mRNA levels in these tissues were 2-10% of that found in the liver of the rat and 10-30% of that found in the liver of the marmoset. Apo-E mRNA was also abundant in human brain and in each species examined; it was distributed throughout all major areas of this organ. In contrast, apo-A-I mRNA was detected in abundant amounts only in the small intestine and in the liver. Extrahepatic apo-E mRNA appears to be functional, generating a translation product similar or identical to that generated by the liver. During fetal and neonatal development, apo-E mRNA is rapidly induced from low levels to approximately equal to 60% of adult levels in liver at parturition. The fetal yolk sac contains more apo-E mRNA than the fetal liver, suggesting a significant role for the yolk sac as a source of apo-E during gestation.

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2 of 2 references verified0 citation errors · 0 not checkable

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  • In the CNS, apoE-cholesterol is principally made in astrocytes and exported to neurons; neurons can also produce apoE-cholesterol during stress.

    “In the CNS, apoE-cholesterol is principally made in astrocytes and exported to neurons [9], [10]; however, neurons can also produce apoE-cholesterol during stress [11].”

    From LDLR Expression and Localization Are Altered in Mouse and Human Cell Culture Models of Alzheimer's Disease (2010) · cites this paper as [10]

    The Discussion says astrocytes appear to be the major, if not the only, brain cells containing apoE. It describes cholesterol transport as a possible role for brain apoE, but does not establish that astrocytes export apoE-associated cholesterol to neurons. The separate claim about neuronal production during stress is attached to citation [11], not this source. (LLM, conf=0.86)

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Research works printed but not linked: 11

  1. [1]Mahley, R. W. (1978) in Disturbances in Lipid and Lipoprotein Metabolism, eds. Dietschy, J. M., Gotto, A. M., Jr., & Ontko, J. A. (Am. Physiol. Soc., Bethesda, MD), pp. 181–197.
  2. [2]Mahley, R. W. (1979) in Atherosclerosis Review, eds. Paoletti, R. & Ġotto, A. M., Jr. (Raven, New York), Vol. 5, pp. 1–34.
  3. [9]Rall, S. C., Jr., Weisgraber, K. H., Innerarity, T. L. & Mahley, R. W. (1982) Proc. Natl. Acad. Sci. USA 79, 4696–4700.
  4. [13]Havel, R. J., Goldstein, J. L. & Brown, M. S. (1980) in Metabolic Control and Disease, eds. Bondy, P. K. & Rosenberg, L. E. (Saunders, Philadelphia), pp. 393–494.
  5. [16]Blue, M. L., Williams, D. L., Zuckers, S., Kahn, S. A. & Blum, C. B. (1983) Proc. Natl. Acad. Sci. USA 80, 283–287.
  6. [15]Basu, S. K., Brown, M. S., Ho, Y. K., Havel, R. J. & Goldstein, J. L. (1981) Proc. Natl. Acad. Sci. USA 78, 7545–7549.
  7. [17]Williams, D. L., Dawson, P. A., Newman, T. C. & Rudel, L. L. (1984) Fed. Proc. Fed. Am. Soc. Exp. Biol. 43, 1816 (abstr.).
  8. [21]Thomas, P. S. (1980) Proc. Natl. Acad. Sci. USA 77, 5201– 5205.
  9. [23]Breslow, J. L., Ross, D., McPherson, J., Williams, H., Kurnit, D., Nussbaum, A. L., Karanthanasis, S. K. & Zannis, V. I. (1982) Proc. Natl. Acad. Sci. USA 79, 6861–6865.
  10. [31]Ham, A. W. & Cormack, D. H. (1979) Histology (Lippincott, Philadelphia), 8th Ed., pp. 509–515.
  11. [35]Roheim, P. S., Carey, M., Forte, T. & Vega, G. L. (1979) Proc. Natl. Acad. Sci. USA 76, 4646–4649.

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Metadata

Authors
Elshourbagy, N. A., Liao, W. S., Mahley, R. W., & Taylor, J. M.
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1985-01
Volume
82
Issue
1
Pages
203-207
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.82.1.203
Cited by
376
References
2
Language
en

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