Cited by 219Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressEicosanoids and Hypertension Pharmacology

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Mechanism of action of some inhibitors of endothelium-derived relaxing factor

Open access

Moncada, S, Palmer, R M, Gryglewski, R J·1986·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.83.23.9164PMC PMC387095

Open this paper in CoChat — free account

Abstract

The mechanism of the inhibitory action of phenidone, 3-amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline (BW 755C), dithiothreitol, hydroquinone, and pyrogallol on the vascular relaxation induced by endothelium-derived relaxing factor (EDRF) was investigated. EDRF was released from porcine aortic endothelial cells in culture and bioassayed on a cascade of superfused rabbit aortic strips. These compounds inhibited EDRF-induced relaxation of vascular strips, without affecting the relaxation induced by glyceryl trinitrate, and their inhibitory potency was markedly attenuated (by more than 1 order of magnitude) by the addition of superoxide dismutase (5-15 units/ml) or oxidized cytochrome c (20-40 microM) but not by catalase (30 units/ml) or heat-inactivated superoxide dismutase. These data indicate that the above five inhibitors inactivate EDRF through the formation of superoxide ions, which have recently been shown to destroy EDRF. The inhibition of EDRF by these compounds is therefore attributable to their redox properties rather than to any specific biological action.

Integrity signals

Registry

Crossref · 10.1073/pnas.83.23.9164

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
Marklund, S. L., & MARKLUND, G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03714.x · Cited by 10,382
The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
Misra, H. P., & Fridovich, I. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45228-9 · Cited by 9,097
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent
Babior, B. M., Kipnes, R. S., & Curnutte, J. T. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107236 · Cited by 2,931
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,400
Self-citation
Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.
Martin, W., Villani, G. M., Jothianandan, D., & Furchgott, R. F. (1985) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20898-9 · Cited by 1,259
The importance of free radicals and catalytic metal ions in human diseases.
Halliwell, B., & Gutteridge, J. M. C. (1985) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(85)90001-9 · Cited by 941
The Role of Endothelium in the Responses of Vascular Smooth Muscle to Drugs
Furchgott, R. F. (1984) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.24.040184.001135 · Cited by 937
The nature of endothelium-derived vascular relaxant factor
Griffith, T. M., Edwards, D. H., LEWIS, M. J., Newby, A. C., & Henderson, A. H. (1984) · Nature · doi:10.1038/308645a0 · Cited by 581
Generation of Superoxide Free Radical during the Autoxidation of Thiols
Misra, H. P. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42810-x · Cited by 556
A new approach to anti-inflammatory drugs
Higgs, G. A., Flower, R. J., & Vane, J. R. (1979) · Biochemical Pharmacology · doi:10.1016/0006-2952(79)90651-8 · Cited by 503

Show all 20 references

Sorted by citations

Nitric Oxide and Peroxynitrite in Health and Disease
Pacher, P., Beckman, J. S., & Liaudet, L. (2007) · Physiological Reviews · doi:10.1152/physrev.00029.2006 · Cited by 6,390
Nitric oxide donors: chemical activities and biological applications
Wang, P. G., Xian, M., Tang, X., Wu, X., Wen, Z., Cai, T., & Janczuk, A. J. (2002) · Chemical Reviews · doi:10.1021/cr000040l · Cited by 1,337
Biosynthesis And Metabolism Of Endothelium-Derived Nitric Oxide
Ignarro, L. J. (1990) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.30.040190.002535 · Cited by 1,300
Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.
Ignarro, L. J., Byrns, R. E., Buga, G. M., & Wood, K. S. (1987) · Circulation Research · doi:10.1161/01.res.61.6.866 · Cited by 1,164
Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.
Ignarro, L. J. (1989) · Circulation Research · doi:10.1161/01.res.65.1.1 · Cited by 964
The discovery of nitric oxide and its role in vascular biology
Moncada, S., & Higgs, E. A. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706458 · Cited by 863
Self-citation
Vascular nitric oxide: Beyond eNOS
Zhao, Y., Vanhoutte, P. M., & Leung, S. W. S. (2015) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2015.09.002 · Cited by 875
Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex
Lei, S. Z., Pan, Z., Aggarwal, S. K., Chen, H.-S. V., Hartman, J., Sucher, N. J., & Lipton, S. A. (1992) · Neuron · doi:10.1016/0896-6273(92)90130-6 · Cited by 740
Endothelium-derived relaxing factor
Moncada, S., Radomski, M. W., & Palmer, R. M. J. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90236-5 · Cited by 676
Self-citation
Biochemistry of Peroxynitrite and Protein Tyrosine Nitration
Ferrer‐Sueta, G., Campolo, N., Trujillo, M., Bartesaghi, S., Carballal, S., Romero, N., Álvarez, B., & Radí, R. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00568 · Cited by 653
Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission
Sanders, K. M., & Ward, S. M. (1992) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1992.262.3.g379 · Cited by 592
Measurement of Nitric Oxide and Peroxynitrite Generation in the Postischemic Heart
Wang, P., & Zweier, J. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.46.29223 · Cited by 542
Endothelium-Dependent Hyperpolarization
Cohen, R. A., & Vanhoutte, P. M. (1995) · Circulation · doi:10.1161/01.cir.92.11.3337 · Cited by 518
The discovery of nitric oxide as the endogenous nitrovasodilator.
Moncada, S., Palmer, R. M. J., & Higgs, E. A. (1988) · Hypertension · doi:10.1161/01.hyp.12.4.365 · Cited by 496
Self-citation
NITRERGIC TRANSMISSION: NITRIC OXIDE AS A MEDIATOR OF NON‐ADRENERGIC, NON‐CHOLINERGIC NEURO‐EFFECTOR TRANSMISSION
Rand, M. J. (1992) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1992.tb00433.x · Cited by 364
Mediators produced by the endothelial cell.
Gryglewski, R. J., Botting, R. M., & Vane, J. R. (1988) · Hypertension · doi:10.1161/01.hyp.12.6.530 · Cited by 324
Self-citation
The Pharmacology of Nitric Oxide in the Peripheral Nervous System of Blood Vessels
Toda, N., & Okamura, T. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.3 · Cited by 309
Reversible conversion of nitroxyl anion to nitric oxide by superoxide dismutase.
Murphy, M. E., & Sies, H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10860 · Cited by 303
Endothelium-Derived Relaxing Factor: Discovery, Early Studies, and Identification as Nitric Oxide
Furchgott, R. F. (1999) · Bioscience Reports · doi:10.1023/a:1020537506008 · Cited by 302
Regulation of obesity and insulin resistance by nitric oxide
Sansbury, B. E., & Hill, B. G. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.016 · Cited by 274
“A few years later, NO was identified as the key endothelium-derived molecule promoting vasodilation: NO synthesized by NOS in the endothelium diffuses into the vessel wall where it activates sGC in vascular smooth muscle; this leads to a rise in cyclic GMP (cGMP) and elicits relaxation of the vessel [96–102].”
Background
Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells.
Sneddon, J. M., & Vane, J. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2800 · Cited by 257
Cyclic GMP and mechanisms of vasodilation
Lincoln, T. (1989) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(89)90127-7 · Cited by 251
Understanding the controversy over the identity of EDRF
Feelisch, M., Poel, M. C. T., Zamora, R., Deußen, A., & Moncada, S. (1994) · Nature · doi:10.1038/368062a0 · Cited by 242
Self-citation
Vascular effects of oxygen-derived free radicals
Rubanyi, G. M. (1988) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(88)90071-8 · Cited by 233
Bioassay of prostacyclin and endothelium‐derived relaxing factor (EDRF) from porcine aortic endothelial cells
Gryglewski, R. J., Moncada, S., & Palmer, R. M. J. (1997) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1997.tb06839.x · Cited by 226
Self-citation
Inhibition of coronary artery superoxide dismutase attenuates endothelium-dependent and -independent nitrovasodilator relaxation.
Omar, H. Α., Cherry, P., Mortelliti, M. P., Burke-Wolin, T., & Wolin, M. S. (1991) · Circulation Research · doi:10.1161/01.res.69.3.601 · Cited by 212
Native and oxidized low‐density lipoproteins have different inhibitory effects on endothelium‐derived relaxing factor in the rabbit aorta
Jacobs, M., Plane, F., & Bruckdorfer, K. R. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb12045.x · Cited by 185
Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism
Farinelli, S., Park, D. S., & Greene, L. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02325.1996 · Cited by 172
The 1989 Ulf von Euler Lecture Studies on endothelium‐dependent vasodilation and the endothelium‐derived relaxing factor
Furchgott, R. F. (1990) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1990.tb08923.x · Cited by 159
Endothelium-derived relaxing factor
Angus, J. A., & Cocks, T. M. (1989) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(89)90112-5 · Cited by 141
Nitric oxide and relaxation of pig lower urinary tract
Persson, K., & Andersson, K. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14349.x · Cited by 138
Endothelium-Derived Nitric Oxide: Pharmacology and Relationship to the Actions of Organic Nitrate Esters
Ignarro, L. J. (1989) · Pharmaceutical Research · doi:10.1023/a:1015926119947 · Cited by 137
The role of the reactions of ·NO with superoxide and oxygen in biological systems: A kinetic approach
Czapski, G., & Goldstein, S. (1995) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)00081-8 · Cited by 134
Comparative pharmacology of EDRF and nitric oxide on vascular strips
Hutchinson, P. J., Palmer, R. M. J., & Moncada, S. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90563-2 · Cited by 134
Self-citation
Endothelium‐derived relaxing factor is a nitrosyl iron complex with thiol ligands
Vanin, A. F. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80894-9 · Cited by 132
The role of nitrogen oxides in human adaptation to hypoxia
Levett, D. Z. H., Fernandez, B. O., Riley, H. L., Martín, D., Mitchell, K., Leckstrom, C. A., İnce, C., Whipp, B. J., Mythen, M. G., Montgomery, H., et al. (2011) · Scientific Reports · doi:10.1038/srep00109 · Cited by 125
Hyperpolarizing Factors
Quilley, J., Fulton, D. J., & McGiff, J. C. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00039-7 · Cited by 125
Reaction of Human Hemoglobin with Peroxynitrite
Romero, N., Radí, R., Linares, E., Augusto, O., Detweiler, C. D., Mason, R. P., & Denicola, A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305895200 · Cited by 124
Role of arachidonic acid lipoxygenase metabolites in the regulation of vascular tone
Chawengsub, Y., Gauthier, K. M., & Campbell, W. B. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00349.2009 · Cited by 116
The Biological Chemistry of Peroxynitrite
Radí, R., Denicola, A., Álvarez, B., Ferrer‐Sueta, G., & Rubbo, H. (2000) · Elsevier eBooks · doi:10.1016/b978-012370420-7/50005-8 · Cited by 115
Contribution of NO and cytochrome P450 to the vasodilator effect of bradykinin in the rat kidney
Fulton, D. J., McGiff, J. C., & Quilley, J. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14513.x · Cited by 115
Mechanisms of obesity-induced metabolic and vascular dysfunctions
Caldwell, R. W. (2019) · Frontiers in bioscience · doi:10.2741/4758 · Cited by 112
Adventures in vascular biology: a tale of two mediators
Moncada, S. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2005.1775 · Cited by 110
Self-citation
The vital role for nitric oxide in intraocular pressure homeostasis
Reina‐Torres, E., Ieso, M. L. D., Pasquale, L. R., Madekurozwa, M., Sherwood, J. M., Overby, D. R., & Stamer, W. D. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100922 · Cited by 109
In vitroantioxidative activities of three marine oligosaccharides
Wang, P., Jiang, X., Jiang, Y., Hu, X., Mou, H., Li, M., & Guan, H. (2007) · Natural Product Research · doi:10.1080/14786410701371215 · Cited by 107
Vascular bound recombinant extracellular superoxide dismutase type C protects against the detrimental effects of superoxide radicals on endothelium-dependent arterial relaxation.
Abrahamsson, T., Brandt, U., Marklund, S. L., & Sjöqvist, P.-O. (1992) · Circulation Research · doi:10.1161/01.res.70.2.264 · Cited by 107
Methylene Blue in the Hepatopulmonary Syndrome
Rolla, G., Bucca, C. B., & Brussino, L. (1994) · New England Journal of Medicine · doi:10.1056/nejm199410203311617 · Cited by 106
Endothelium-dependent Vasoactive Modulation in the Ophthalmic Circulation
Haefliger, I. O., Flammer, J., Bény, J., & Lüscher, T. F. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(00)00020-3 · Cited by 100
Endothelium-derived nitric oxide relaxes nonvascular smooth muscle
Buga, G. M., Gold, M. E., Wood, K. S., Chaudhuri, G., & Ignarro, L. J. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90180-5 · Cited by 99
Involvement of the l-arginine-nitric oxide pathway in internal anal sphincter relaxation
Tøttrup, A., Glavind, E. B., & Svane, D. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90084-c · Cited by 91
Differentiation by hydroquinone of relaxations induced by exogenous and endogenous nitrates in non‐vascular smooth muscle: role of superoxide anions
Hobbs, A. J., Tucker, J. F., & Gibson, A. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12483.x · Cited by 85
Review article: Update on current and emergent data on hepatopulmonary syndrome
Σουλαϊδόπουλος, Σ., Cholongitas, Ε., Giannakoulas, G. A., Vlachou, M. S., & Goulis, I. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i12.1285 · Cited by 84
MECHANISMS OF GAS EXCHANGE IMPAIRMENT IN PATIENTS WITH LIVER CIRRHOSIS
Agustí, A. G. N., Roca, J., & Rodriguez‐Roisin, R. (1996) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(05)70298-7 · Cited by 84
Control of Skeletal Muscle Blood Flow During Dynamic Exercise
GREEN, D. J., O’Driscoll, G., BLANKSBY, B. A., & Taylor, R. R. (1996) · Sports Medicine · doi:10.2165/00007256-199621020-00004 · Cited by 82
Rabbit polymorphonuclear neutrophils elicit endothelium-dependent contraction in vascular smooth muscle.
Ohlstein, E. H., & Nichols, A. J. (1989) · Circulation Research · doi:10.1161/01.res.65.4.917 · Cited by 80
Comparison of the mechanisms underlying the relaxation induced by two nitric oxide donors: Sodium nitroprusside and a new ruthenium complex
Bonaventura, D., de Lima, R. G., Vercesi, J. A., da Silva, R. S., & Bendhack, L. M. (2006) · Vascular Pharmacology · doi:10.1016/j.vph.2006.10.002 · Cited by 77
Antagonistic modulatory roles of magnesium and calcium on release of endothelium-derived relaxing factor and smooth muscle tone.
Gold, M. E., Buga, G. M., Wood, K. S., Byrns, R. E., Chaudhuri, G., & Ignarro, L. J. (1990) · Circulation Research · doi:10.1161/01.res.66.2.355 · Cited by 73
Differential selectivity of endothelium‐derived relaxing factor and nitric oxide in smooth muscle
Shikano, K., Ohlstein, E. H., & Berkowitz, B. A. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb11347.x · Cited by 73
Vasodilator and vasoconstrictor substances produced by the endothelium
Pearson, P. J., & Vanhoutte, P. M. (1993) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0035273 · Cited by 69
Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling
Rajendran, S., Shen, X., Glawe, J. D., Kolluru, G. K., & Kevil, C. G. (2019) · Comprehensive physiology · doi:10.1002/cphy.c180026 · Cited by 69
Basic polyamino acids rich in arginine, lysine, or ornithine cause both enhancement of and refractoriness to formation of endothelium-derived nitric oxide in pulmonary artery and vein.
Ignarro, L. J., Gold, M. E., Buga, G. M., Byrns, R. E., Wood, K. S., Chaudhuri, G., & Frank, G. D. (1989) · Circulation Research · doi:10.1161/01.res.64.2.315 · Cited by 67
Nitric Oxide Bioavailability in the Microcirculation: Insights from Mathematical Models
Tsoukias, N. M. (2008) · Microcirculation · doi:10.1080/10739680802010070 · Cited by 65
Mechanism of action of EDRF on pressurized arteries: effect on K+ conductance.
Kauser, K. Z., Stekiel, W. J., Rubanyi, G. M., & Harder, D. R. (1989) · Circulation Research · doi:10.1161/01.res.65.1.199 · Cited by 62
Decomposition of protein nitrosothiolsin matrix‐assisted laser desorption/ionization and electrospray ionization mass spectrometry
Kaneko, R., & Wada, Y. (2003) · Journal of Mass Spectrometry · doi:10.1002/jms.466 · Cited by 61
Vasorelaxing Action of Rutaecarpine: Effects of Rutaecarpine on Calcium Channel Activities in Vascular Endothelial and Smooth Muscle Cells
Wang, G.-J., Wu, X., Chen, C.-F., Lin, L.-C., Huang, Y., Shan, J. J., & Pang, P. K. T. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38264-3 · Cited by 61
Role of nitric oxide and guanosine 3′,5′‐cyclic monophosphate in mediating nonadrenergic, noncholinergic relaxation in guinea‐pig pulmonary arteries
Liu, S. F., Crawley, D. E., Rohde, J. A. L., Evans, T. W., & Barnes, P. J. (1992) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1992.tb14538.x · Cited by 60
Nitric Oxide and Peroxynitrite in Postischemic Myocardium
Zweier, J. L., Fertmann, J. M., & Wei, G. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601750100443 · Cited by 59
Receptors for kinins in isolated arterial vessels of dogs
Rhaleb, N., Dion, S., Barabé, J., Rouissi, N., Jukic, D., Drapeau, G., & Regoli, D. C. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90332-4 · Cited by 57
(-)-Epigallocatechin gallate attenuates NADPH-d/nNOS expression in motor neurons of rats following peripheral nerve injury
Wei, I., Tu, H.-C., Huang, C., Tsai, M., Tseng, C., & Shieh, J.-Y. (2011) · BMC Neuroscience · doi:10.1186/1471-2202-12-52 · Cited by 56
Nitric Oxide Metabolite Levels in Acute Vaso‐occlusive Sickle‐cell Crisis
Lopez, B. L., Barnett, J., Ballas, S. K., Christopher, T. A., Davis‐Moon, L., & Ma, X. (1996) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.1996.tb03367.x · Cited by 56
Sequential nitric oxide measurements during the emergency department treatment of acute vasoocclusive sickle cell crisis
Lopez, B. L., Davis‐Moon, L., Ballas, S. K., & Ma, X.-L. (2000) · American Journal of Hematology · doi:10.1002/(sici)1096-8652(200005)64:1 · Cited by 53
Nitric Oxide, Platelet Function, Myocardial Infarction and Reperfusion Therapies
Alonso, D. C., & Radomski, M. W. (2003) · Heart Failure Reviews · doi:10.1023/a:1022194921040 · Cited by 53
Development of Polyethylene Glycol-Conjugated Poly-S-Nitrosated Serum Albumin, a Novel S-Nitrosothiol for Prolonged Delivery of Nitric Oxide in the Blood Circulation in Vivo
Katsumi, H., Nishikawa, M., Yamashita, F., & Hashida, M. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.087429 · Cited by 52
Roles of cyclic GMP in modulating ovarian functions
LaPolt, P. S., Leung, K., Ishimaru, R., Tafoya, M., & Chen, J. Y.-H. (2003) · Reproductive BioMedicine Online · doi:10.1016/s1472-6483(10)62051-2 · Cited by 52
Adenosine 5′-triphosphate, adenosine and endothelium-derived relaxing factor in hypoxic vasodilatation of the heart
Hopwood, A. M., Lincoln, J., Kirkpatrick, K. A., & Burnstock, G. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90730-9 · Cited by 52
Mechanisms of action of lipoxygenase and cytochrome P‐450‐mono‐oxygenase inhibitors in blocking endothelium‐dependent vasodilatation
Förstermann, U., Alheid, U., Frölich, J. C., & Mülsch, A. (1988) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1988.tb10312.x · Cited by 52
EDRF generation and release from perfused bovine pulmonary artery and vein
Ignarro, L. J., Buga, G. M., & Chaudhuri, G. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90045-3 · Cited by 50
Cigarette smoke inhibits macrophage sensing of Gram‐negative bacteria and lipopolysaccharide: relative roles of nicotine and oxidant stress
McMaster, S. K., Paul‐Clark, M. J., Walters, M. J., Fleet, M., Anandarajah, J., Sriskandan, S., & Mitchell, J. A. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707595 · Cited by 48
Nitric oxide is inactivated by the bacterial pigment pyocyanin.
Warren, J. B., Loi, R., Rendell, N. B., & Taylor, G. W. (1990) · Europe PMC (PubMed Central) · Cited by 48
Endothelium protectant and contractile effects of the antivaricose principle escin in rat aorta
Carrasco, O. F., & Vidrio, H. (2007) · Vascular Pharmacology · doi:10.1016/j.vph.2007.04.003 · Cited by 47
Effects of catechins on vascular tone in rat thoracic aorta with endothelium
Sanae, F., Miyaichi, Y., Kizu, H., & Hayashi, H. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02080-5 · Cited by 44
Age‐associated decrease in histamine‐induced vasodilatation may be due to reduction of cyclic GMP formation
Moritoki, H., Tanioka, A., Maeshiba, Y., Iwamoto, T., ISHIDA, Y., & Araki, H. (1988) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1988.tb11734.x · Cited by 44
Inhibitory effects of a fullerene derivative, dimalonic acid C60, on nitric oxide-induced relaxation of rabbit aorta
Satoh, M., Matsuo, K., Kiriya, H., Mashino, T., Nagano, T., Hirobe, M., & Takayanagi, I. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)89658-6 · Cited by 44
Inhibitory effects of superoxide dismutase and cyclic guanosine 3',5'- monophosphate on estrogen production in cultured rat granulosa cells
LaPolt, P. S., & Hong, L. (1995) · Endocrinology · doi:10.1210/en.136.12.5533 · Cited by 43
Na+-Ca2+Exchange in Intact Endothelium of Rabbit Cardiac Valve
Li, L., & van Breemen, C. (1995) · Circulation Research · doi:10.1161/01.res.76.3.396 · Cited by 42
Non‐adrenergic, non‐cholinergic relaxation of the bovine retractor penis muscle: role of S‐nitrosothiols
Liu, X., Gillespie, J. S., & Martin, W. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb14885.x · Cited by 42
Evaluation of nitroalkenes as nitric oxide donors
Gorczynski, M. J., Huang, J., Lee, H. J., & King, S. (2007) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2007.01.016 · Cited by 41
The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow
Lakshminrusimha, S., Wiseman, D. A., Black, S. M., Russell, J. A., Gugino, S. F., Oishi, P. E., Steinhorn, R. H., & Fineman, J. R. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00185.2007 · Cited by 41
Superoxide dismutase reduces permeability and edema induced by hypertension in rats
Zhang, X. M., & Ellis, E. F. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.259.2.h497 · Cited by 41
Hypertension, endothelium, and cardiovascular risk factors
Raij, L. R. (1991) · The American Journal of Medicine · doi:10.1016/0002-9343(91)90029-w · Cited by 39
Cyclic GMP release and vasodilatation induced by EDRF and atrial natriuretic factor in the isolated perfused kidney of the rat
Burton, G. A., MacNeil, S., Jonge, A. D., & Haylor, J. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb14709.x · Cited by 39
Influence of superoxide dismutase inhibition on the discrimination between NO and the nitrergic neurotransmitter in the rat gastric fundus
Lefebvre, R. A. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15659.x · Cited by 39
Design and Evaluation of S-Nitrosylated Human Serum Albumin as a Novel Anticancer Drug
Katayama, N., Nakajou, K., Komori, H., Uchida, K., Yokoe, J.-I., Yasui, N., Yamamoto, H., Kai, T., Sato, M., Nakagawa, T., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.132100 · Cited by 38
Endothelium-dependent relaxation, endothelium-derived relaxing factor and photorelaxation of blood vessels.
Furchgott, R. F. (1991) · PubMed · Cited by 38
Effect of carbenoxolone on the biological activity of nitric oxide: relation to gastroprotection
Dembinska-Kiec, A., Pallapies, D., Simmet, T., Peskar, B. M., & Peskar, B. A. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12511.x · Cited by 37
A new synthetic flavonoid protects endothelium-derived relaxing factor-induced relaxation in rabbit arteries in vitro: Evidence for superoxide scavenging
Girard, P., Sercombe, R., Sercombe, C., Lem, G. L., Seylaz, J., & Potìer, P. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(94)00526-r · Cited by 37
The paracrine control of vascular motion. A historical perspective
Nava, E., & Llorens, S. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.08.003 · Cited by 36
Bang‐Bang Model for Regulation of Local Blood Flow
Golub, A. S., & Pittman, R. N. (2013) · Microcirculation · doi:10.1111/micc.12051 · Cited by 36
Nitric Oxide Inhibition of ERK1/2 Activity in Cells Expressing Neuronal Nitric-oxide Synthase
Raines, K. W., Cao, G.-L., Porsuphatana, S., Tsai, P., Rosen, G. M., & Shapiro, P. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m304813200 · Cited by 36
Blockade of nitrergic transmission by hydroquinone, hydroxocobalamin and carboxy‐PTIO in bovine retractor penis: role of superoxide anion
Paisley, K., & Martin, W. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15333.x · Cited by 36

Authors: Moncada, S., Palmer, R. M., & Gryglewski, R. J.
ORCID: Moncada, S
Palmer, R M
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1986-12
Volume: 83
Issue: 23
Pages: 9164-9168
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.83.23.9164
PMC: PMC387095
OpenAlex: W2076583182
Cited by: 219
References: 20
Citations by year: 2025: 1 · 2023: 1 · 2022: 3 · 2020: 2 · 2019: 4 · 2018: 3 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 6
FWCI: 14.09
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: endothelium-derived relaxing factor, nitric oxide, nitric oxide inhibitors, phenidone, BW755C, dithiothreitol, hydroquinone, pyrogallol, superoxide, superoxide dismutase, oxidized cytochrome c, vasorelaxation, porcine aortic endothelial cells, nitroglycerin
MeSH terms: Animals, Cytochrome c Group, Dithiothreitol, Endothelium, Hydroquinones, Muscle, Smooth, Vascular, Nitric Oxide, Oxidation-Reduction, Pyrazoles, Pyrogallol, Superoxide Dismutase, Swine, Vasodilator Agents, 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mechanism of action of some inhibitors of endothelium-derived relaxing factor

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks