Cited by 219Nitric Oxide and Endothelin EffectsRedox biology and oxidative stressEicosanoids and Hypertension Pharmacology

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

Mechanism of action of some inhibitors of endothelium-derived relaxing factor

Open access

Moncada, S, Palmer, R M, Gryglewski, R J·1986·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.83.23.9164PMC PMC387095

Open this paper in CoChat — free account

Abstract

The mechanism of the inhibitory action of phenidone, 3-amino-1-[m-(trifluoromethyl)phenyl]-2-pyrazoline (BW 755C), dithiothreitol, hydroquinone, and pyrogallol on the vascular relaxation induced by endothelium-derived relaxing factor (EDRF) was investigated. EDRF was released from porcine aortic endothelial cells in culture and bioassayed on a cascade of superfused rabbit aortic strips. These compounds inhibited EDRF-induced relaxation of vascular strips, without affecting the relaxation induced by glyceryl trinitrate, and their inhibitory potency was markedly attenuated (by more than 1 order of magnitude) by the addition of superoxide dismutase (5-15 units/ml) or oxidized cytochrome c (20-40 microM) but not by catalase (30 units/ml) or heat-inactivated superoxide dismutase. These data indicate that the above five inhibitors inactivate EDRF through the formation of superoxide ions, which have recently been shown to destroy EDRF. The inhibition of EDRF by these compounds is therefore attributable to their redox properties rather than to any specific biological action.

Integrity signals

Registry

Crossref · 10.1073/pnas.83.23.9164

Cites

21 of 21 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
Marklund, S. L., & MARKLUND, G. (1974) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1974.tb03714.x · Cited by 10,382
The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase
Misra, H. P., & Fridovich, I. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45228-9 · Cited by 9,097
Biological defense mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent
Babior, B. M., Kipnes, R. S., & Curnutte, J. T. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107236 · Cited by 2,931
Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
Gryglewski, R. J., Palmer, R. M. J., & Moncada, S. (1986) · Nature · doi:10.1038/320454a0 · Cited by 2,400
Self-citation
Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.
Martin, W., Villani, G. M., Jothianandan, D., & Furchgott, R. F. (1985) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)20898-9 · Cited by 1,259
The importance of free radicals and catalytic metal ions in human diseases.
Halliwell, B., & Gutteridge, J. M. C. (1985) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(85)90001-9 · Cited by 941
The Role of Endothelium in the Responses of Vascular Smooth Muscle to Drugs
Furchgott, R. F. (1984) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.24.040184.001135 · Cited by 937
The nature of endothelium-derived vascular relaxant factor
Griffith, T. M., Edwards, D. H., LEWIS, M. J., Newby, A. C., & Henderson, A. H. (1984) · Nature · doi:10.1038/308645a0 · Cited by 581
Generation of Superoxide Free Radical during the Autoxidation of Thiols
Misra, H. P. (1974) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)42810-x · Cited by 556
A new approach to anti-inflammatory drugs
Higgs, G. A., Flower, R. J., & Vane, J. R. (1979) · Biochemical Pharmacology · doi:10.1016/0006-2952(79)90651-8 · Cited by 503

Flagged first, then by citations

Show all 20 references

Sorted by citations

Items 101–200 of 218

Halothane Impairs the Hemodynamic Influence of Endothelium-derived Nitric Oxide
Sigmon, D. H., Florentino‐Pineda, I., Dyke, R. A. V., & Beierwaltes, W. H. (1995) · Anesthesiology · doi:10.1097/00000542-199501000-00018 · Cited by 35
Cardiovascular autonomic modulation differences between moderate-intensity continuous and high-intensity interval aerobic training in women with PCOS: A randomized trial
Philbois, S. V., Ribeiro, V. B., Tank, J., dos Reis, R. M., Gerlach, D. A., & de Souza, H. C. D. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1024844 · Cited by 34
Endothelium-derived relaxing factor: Basic review and clinical implications
Johns, R. A. (1991) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1016/1053-0770(91)90099-f · Cited by 34
Identification and partial purification of an endogenous inhibitor of soluble guanylyl cyclase from bovine lung.
Kim, T. D., & Burstyn, J. N. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40713-7 · Cited by 34
N-Acetylcysteine Enhances Endothelium-Dependent Vasorelaxation in the Isolated Rat Mesenteric Artery
Lopez, B. L., Snyder, J. W., Birenbaum, D. S., & Ma, X. (1998) · Annals of Emergency Medicine · doi:10.1016/s0196-0644(98)70167-2 · Cited by 33
Die Entdeckung einiger biologischer Wirkungen von Stickstoffmonoxid und seiner Rolle für die Zellkommunikation (Nobel-Vortrag)
Murad, F. (1999) · Angewandte Chemie · doi:10.1002/(sici)1521-3757(19990712)111:13/14 · Cited by 57
Endothelium-dependent relaxant action of platelet activating factor in the rat mesenteric artery
Chiba, Y., Mikoda, N., Kawasaki, H., & Ito, K. (1990) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/bf00195060 · Cited by 32
ENDOTHELIUM‐DERIVED RELAXING FACTOR RELEASED FROM CULTURED CELLS: DIFFERENTIATION FROM NITRIC OXIDE
Dusting, G. J., Read, M. A., & Stewart, A. G. (1988) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1988.tb01049.x · Cited by 32
Role of paraquat in the uncoupling of nitric oxide synthase
Margolis, A. S., Porasuphatana, S., & Rosen, G. M. (2000) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(00)00167-7 · Cited by 30
NO and the Vasculature: Where Does It Come from and What Does It Do?
Andrews, K. L., Triggle, C. R., & Ellis, A. (2002) · Heart Failure Reviews · doi:10.1023/a:1020702215520 · Cited by 31
Attenuation of oxidative stress-induced vascular endothelial dysfunction by thymoquinone
El‐Agamy, D. S., & Nader, M. A. (2012) · Experimental Biology and Medicine · doi:10.1258/ebm.2012.012107 · Cited by 29
Endothelium‐derived relaxing factor (EDRF) and nitric oxide (NO). I. Physiology, pharmacology and pathophysiological implications
Feng, Q., & Hedner, T. (1990) · Clinical Physiology · doi:10.1111/j.1475-097x.1990.tb00822.x · Cited by 29
THE INHIBITION OF NITRIC OXIDE‐MEDIATED RELAXATIONS IN RAT AORTA AND ANOCOCCYGEUS MUSCLE BY DIPHENYLENE IODONIUM
Rand, M. J., & Li, C. G. (1993) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.1993.tb01661.x · Cited by 27
Humoral factor mediates acetylcholine-induced endothelium-dependent relaxation of chicken aorta
Hasegawa, K., & Nishimura, H. (1991) · General and Comparative Endocrinology · doi:10.1016/0016-6480(91)90076-i · Cited by 26
Comparison of early microcirculatory and aortic changes in hypercholesterolemic rats.
Schuschke, D. A., Joshua, I. G., & Miller, F. N. (1991) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.11.1.154 · Cited by 26
Actions and interactions of NG‐substituted analogues of l ‐arginine on NANC neurotransmission in the bovine retractor penis and rat anococcygeus muscles
Martin, W., Gillespie, J. S., & Gibson, I. F. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13469.x · Cited by 26
Effects of the superoxide dismutase-mimic compound tempol on oxidant stress-mediated endothelial dysfunction
Haj-Yehia, A. I., Nassar, T., Assaf, P., Nassar, H., & Änggård, E. E. (1999) · Antioxidants & Redox Signaling · doi:10.1089/ars.1999.1.2-221 · Cited by 25
Antiobesogenic Role of Endothelial Nitric Oxide Synthase
Sansbury, B. E., & Hill, B. G. (2014) · Vitamins and hormones · doi:10.1016/b978-0-12-800254-4.00013-1 · Cited by 26
Effects of arginine vasopressin and extracellular osmolarity on atrial natriuretic peptide release by superfused rat atria
Zongaso, M. A., Carayon, A., Masson, F., Maistre, G., Noé, E., Eurin, J., Barthélemy, C., Michel Komajda, N., & Legrand, J. C. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90009-f · Cited by 25
Contribution of Nitric Oxide to the Beneficial Effects of Enalapril in the Fructose-Induced Hyperinsulinemic Rat
Erlich, Y., & Rosenthal, T. (1996) · Hypertension · doi:10.1161/01.hyp.28.5.754 · Cited by 25
Superoxide dismutase decreases mortality, blood pressure, and cerebral blood flow responses induced by acute hypertension in rats.
Zhang, X. M., & Ellis, E. F. (1991) · Stroke · doi:10.1161/01.str.22.4.489 · Cited by 25
Role of endothelium in hypoxic contraction of canine basilar artery
Elliott, D., Ong, B. Y., Bruni, J., & Böse, D. (1989) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1989.tb11906.x · Cited by 24
Mutagenicity of nitric oxide-releasing compounds in Escherichia coli: effect of superoxide generation and evidence for two mutagenic mechanisms
Martínez‐Romero, A., Urios, A., Felipo, V., & Blanco, M. (2001) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(01)00258-3 · Cited by 23
Heterogeneity of endothelium-dependent and independent responses among large and small porcine pulmonary arteries
Zellers, T. M., & Vanhoutte, P. M. (1989) · Pulmonary Pharmacology · doi:10.1016/0952-0600(89)90021-5 · Cited by 23
INHIBITION OF AGONIST-INDUCED VASOCONTRACTION AND IMPAIRMENT OF ENDOTHELIUM-DEPENDENT VASORELAXATION BY EXTRACT OF MOTORCYCLE EXHAUST PARTICLES IN VITRO
Yu-Wen Cheng, J.-J. K. (1999) · Journal of Toxicology and Environmental Health · doi:10.1080/009841099157791 · Cited by 23
Modulating Nitric Oxide Release byS-Nitrosothiol Photocleavage: Mechanism and Substituent Effects
Marazzi, M., López-Delgado, A., Fernández-González, M. Á., Castaño, O., Frutos, L. M., & Temprado, M. (2012) · The Journal of Physical Chemistry A · doi:10.1021/jp304707n · Cited by 22
Luminol chemiluminescense reaction: a new method for monitoring nitric oxide in vivo
Yao, D., Vlessidis, A. G., Evmiridis, N. P., Evangelou, A. M., Karkabounas, S., & Tsampalas, S. (2002) · Analytica Chimica Acta · doi:10.1016/s0003-2670(02)00070-3 · Cited by 22
Superoxide anion and endothelial regulation of arterial tone.
Katušić, Z. S., & Vanhoutte, P. M. (1991) · PubMed · Cited by 22
Thiols Mediate Superoxide-dependent NADH Modification of Glyceraldehyde-3-phosphate Dehydrogenase
Rivera–Nieves, J., Thompson, W. C., Levine, R. L., & Moss, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.28.19525 · Cited by 22
Mechanisms of the Hypolipidemic Effect of NIP-200 in Rats
Sakashita, M., Toyoda, K., Kitahara, M., Tsuruzoe, N., NAKAYAMA, S., & Oguchi, K. (1993) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.62.305 · Cited by 22
Methylene Blue and Cirrhosis: Pathophysiologic Insights, Therapeutic Dilemmas
Fallon, M. B. (2000) · Annals of Internal Medicine · doi:10.7326/0003-4819-133-9-200011070-00016 · Cited by 21
Gold nanoparticle modifies nitric oxide release and vasodilation in rat aorta
Silva, B. R., Lunardi, C. N., Araki, K., Biazzotto, J. C., da Silva, R. S., & Bendhack, L. M. (2014) · Journal of Chemical Biology · doi:10.1007/s12154-014-0109-x · Cited by 19
Relative roles of nitric oxide and cyclo‐oxygenase and lipoxygenase products of arachidonic acid in the contractile responses of rat renal arcuate arteries
Wu, X. C., Richards, N. T., Michael, J., & Johns, E. J. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb13081.x · Cited by 19
Physicochemical, tissue distribution, and vasodilation characteristics of nitrosated serum albumin: delivery of nitric oxide in vivo
Katsumi, H., Nishikawa, M., Ma, S.-F., Yamashita, F., & Hashida, M. (2004) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20147 · Cited by 19
Endothelial factors in the regulation of renin release
Campbell, W. B., & Henrich, W. L. (1990) · Kidney International · doi:10.1038/ki.1990.250 · Cited by 19
Interdependence of contractile responses of rat small mesenteric arteries on nitric oxide and cyclo‐oxygenase and lipoxygenase products of arachidonic acid
Wu, X. C., Johns, E. J., Michael, J., & Richards, N. T. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb13080.x · Cited by 19
Endothelial modulation of the ouabain-induced contraction in human placental vessels.
Sánchez‐Ferrer, C. F., Fernández‐Alfonso, M. S., Ponte, A., Casado, M. Á., González, R., Rodríguez‐Mañas, L., Pareja, A., & Marín, J. (1992) · Circulation Research · doi:10.1161/01.res.71.4.943 · Cited by 19
Endothelium‐Dependent Tolerance to Ethanol‐Induced Contraction of Rat Aorta: Effect of Inhibition of EDRF Action and Nitric Oxide Synthesis
Knych, E. T. (1992) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1992.tb00636.x · Cited by 19
Mechanisms underlying the vascular relaxation induced by a new nitric oxide generator
Rodrigues, G. J., Cicillini, S. A., da Silva, R. S., & Bendhack, L. M. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.06.002 · Cited by 19
Is the knowledge on tissue microcirculation important for microsurgeon?
Kusza, K., & Siemionow, M. (2011) · Microsurgery · doi:10.1002/micr.20927 · Cited by 18
Síndrome hepatopulmonar: patogenia, diagnóstico e tratamento
LIMA, B. P. R. S. D. A., Martinelli, A. D. L. C., & França, A. V. C. (2004) · Arquivos de Gastroenterologia · doi:10.1590/s0004-28032004000400010 · Cited by 18
Extracellular Nitric Oxide Release Mediates Soluble Guanylate Cyclase-Independent Vasodilator Action of Spermine NONOate: Comparison with Other Nitric Oxide Donors in Isolated Rat Femoral Arteries
Miller, M. R., Okubo, K., Roseberry, M. J., Webb, D. J., & Megson, I. L. (2004) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-200403000-00016 · Cited by 18
Ketamine and Midazolam Differentially Inhibit Nonadrenergic Noncholinergic Lower Esophageal Sphincter Relaxation in Rabbits
Kohjitani, A., Miyawaki, T., Funahashi, M., Higuchi, H., Matsuo, R., & Shimada, M. (2003) · Anesthesiology · doi:10.1097/00000542-200302000-00026 · Cited by 18
A cellular model for screening neuronal nitric oxide synthase inhibitors
Fang, J., & Silverman, R. B. (2009) · Analytical Biochemistry · doi:10.1016/j.ab.2009.04.004 · Cited by 17
Next Generation Sequencing Discoveries of the Nitrate-Responsive Oral Microbiome and Its Effect on Vascular Responses
Grant, M. M., & Jönsson, D. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8081110 · Cited by 17
Induction of guinea pig airway hyperresponsiveness by inactivation of guanylate cyclase
Sadeghi-Hashjin, G., Folkerts, G., Henricks, P. A. J., de Loo, P. G. F. V., van der Linde, H. J., Dik, I. E. M., & Nijkamp, F. P. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(96)00081-7 · Cited by 17
Sevoflurane reduces endothelium-dependent vasorelaxation: role of Superoxide anion and endothelin
Arriero, M., Alameda, L. E. M., López-Farré, A. J., Burgos, M. A. C., Carrasco, C., Millás, I., Celdrán, Á., & de la Pinta, J. C. (2002) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/bf03017923 · Cited by 16
Chronic Hypoxia Attenuates Nitric Oxide-Dependent Hemodynamic Responses to Acute Hypoxia
Huang, K., Wu, C., Kang, B., & Lin, Y. (2002) · Journal of Biomedical Science · doi:10.1007/bf02256067 · Cited by 16
Non-Prostanoid Endothelium-Derived Vasoactive Factors
Dinh‐Xuan, A. T., & Higenbottam, T. (1989) · Journal of International Medical Research · doi:10.1177/030006058901700401 · Cited by 16
Endothelium‐dependent contraction of rat thoracic aorta induced by gallic acid
Sanae, F., Miyaichi, Y., & Hayashi, H. (2003) · Phytotherapy Research · doi:10.1002/ptr.1255 · Cited by 15
Effect of SKF 525A on the release of nitric oxide and prostacyclin from endothelial cells
Rees, D. D., Palmer, R. M. J., & Moncada, S. (1988) · European Journal of Pharmacology · doi:10.1016/0014-2999(88)90761-3 · Cited by 14
Self-citation
Mechanisms of vascular injury
Raij, L. R. (1991) · Journal of the American Society of Nephrology · doi:10.1681/asn.v22s2 · Cited by 14
Nonradical oxidants of the phagocyte type induce the activation of plasmatic single chain- urokinase
Stief, T. W., Stief, M. H., Ehrenthal, W., Darius, H., & Martin, E. (1991) · Thrombosis Research · doi:10.1016/s0049-3848(05)80009-x · Cited by 14
Response to the Endothelium-Dependent Vasodilator Acetylcholine in Perfused Kidneys of Normotensive and Spontaneously Hypertensive Rats
Tuncer, M., & Vanhoutte, P. M. (1993) · Blood Pressure · doi:10.3109/08037059309077554 · Cited by 13
2,5-Di-t-butyl-1,4-benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta
Fusi, F., Valoti, M., Frosini, M., & Sgaragli, G. P. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00932-7 · Cited by 12
Structural Substituent Effect in the Excitation Energy of a Chromophore: Quantitative Determination and Application to S-Nitrosothiols
Fernández-González, M. Á., Marazzi, M., López-Delgado, A., Zapata, F., García‐Iriepa, C., Rivero, D., Castaño, O., Temprado, M., & Frutos, L. M. (2012) · Journal of Chemical Theory and Computation · doi:10.1021/ct300597u · Cited by 12
A paradigm shift for local blood flow regulation
Golub, A. S., & Pittman, R. N. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00964.2013 · Cited by 12
Role of endothelium in endotoxin blockade of voltage-sensitive Ca2+ channels in smooth muscle cells
Goligorsky, M. S. (1989) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1989.257.5.c875 · Cited by 11
Decreased intrahepatic response to α1‐adrenergic agonists in lipopolysaccharide‐treated rats is located in the sinusoidal area and depends on Kupffer cell function
Lee, C., Loureiro‐Silva, M. R., Abraldeṣ, J. G., Iwakiri, Y., Haq, O., & Groszmann, R. J. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.04922.x · Cited by 10
Use of Cultured Cells to Study the Relationship Between Arachidonic Acid and Endothelium-Derived Relaxing Factor
Johns, R. A., Izzo, N. J., Milner, P. J., Loeb, A. L., & Peach, M. J. (1988) · The American Journal of the Medical Sciences · doi:10.1097/00000441-198804000-00012 · Cited by 10
Membrane sampler for interference-free flow injection NO determination in biological fluids with chemiluminescence detection
Yao, D., Prodromidis, M. I., Vlessidis, A. G., Karayannis, M. I., & Evmiridis, N. P. (2001) · Analytica Chimica Acta · doi:10.1016/s0003-2670(01)01369-1 · Cited by 9
Involvement of NK receptors and β-adrenoceptors in nitric oxide-dependent relaxation of rabbit aorta rings following electrical-field stimulation
Persico, P., Calignano, A., Mancuso, F., & Sorrentino, L. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90512-g · Cited by 9
Sodium pump activation by 5-hydroxytryptamine in human placental veins
Fernández‐Alfonso, M. S., Sánchez‐Ferrer, C. F., & Marı́n, J. (1992) · European Journal of Pharmacology · doi:10.1016/0014-2999(92)90699-5 · Cited by 8
Endogenous Production of Nitric Oxide and Effects of Nitric Oxide and Superoxide on Melanotrope Functioning in the Pituitary Pars Intermedia of Xenopus laevis
Allaerts, W., Koopman, W. J. H., Verlaan, B., Buzzi, M., & Steerenberg, P. A. (2000) · Nitric Oxide · doi:10.1006/niox.1999.0266 · Cited by 8
A copper-complex reduced gastric damage caused by acetylsalicylic acid and ethanol
Franco, L., & Velo, G. P. (1996) · Prostaglandins · doi:10.1016/0090-6980(96)00025-1 · Cited by 8
Redox Regulation of Microvascular Physiology and Pathophysiology: Insights into Therapeutic Strategies and Limitations
Bulger, D. A., Zhang, Z., Hu, R., Dave, E. K., Mehta, P. K., Griendling, K. K., & Valdivia, A. (2025) · Antioxidants and Redox Signaling · doi:10.1177/15230864251372607 · Cited by 8
Oximes Induce Erection and Are Resistant to Oxidative Stress
Pauwels, B., Boydens, C., Brouckaert, P., & de Voorde, J. V. (2015) · The Journal of Sexual Medicine · doi:10.1111/jsm.12846 · Cited by 7
Negative Inotropic and Chronotropic Effects of Phenolic Fraction from Cynodon dactylon (linn) on Isolated Perfused Frog Heart
Shabi, M. M., Raj, C. D., Sasikala, C., Gayathri, K. C., & Joseph, J. (2012) · Journal of Scientific Research · doi:10.3329/jsr.v4i3.8549 · Cited by 7
Role of nitric oxide in prevention of ethanol-induced gastric damage by CuNSN a copper-chelating compound
Franco, L. (1995) · Inflammation Research · doi:10.1007/bf01630484 · Cited by 7
Modulation of nitric oxide effects by flurbiprofen enantiomers and nefopam and its relation to antinociception
Pallapies, D., Paskar, B. A., Brune, K., & Zeilhofer, H. U. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)90791-9 · Cited by 7
The inhibition of release of endothelium‐derived relaxant factor by manoalide, a potent inhibitor of phospholipase A2
Long, C. J., Sarau, H. M., & Berkowitz, B. A. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb11389.x · Cited by 7
Nitric Oxide, Platelet Function, Myocardial Infarction and Reperfusion Therapies
Alonso, D. C., & Radomski, M. W. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-7960-5_4 · Cited by 7
Reperfusion Injury in Gastric Mucosa
Yoshikawa, T., & Naito, Y. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb36727.x · Cited by 7
Does luminal release of EDRF contribute to downstream microvascular tone?
Klotz, K. ‐., Gaehtgens, P. A. L., & Pries, A. R. (1995) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf01837412 · Cited by 6
Influence of redox compounds on nitrovasodilator‐induced relaxations of rat coronary arteries
Murphy, M. E. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702777 · Cited by 6
Generation of Superoxide Anion Impairs Histamine-Induced Increases in Macromolecular Efflux
Mayhan, W. G., & Sharpe, G. M. (2001) · Microvascular Research · doi:10.1006/mvre.2001.2313 · Cited by 5
Modification by Hydroxyl Radicals of Functional Reactivity in Rabbit Lingual Artery
SASAKI, H., & Okabe, E. (1993) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.62.407 · Cited by 5
The location of photodegradable nitric oxide store in the mouse stomach fundus
Öğülener, N., Döndaş, N. Y., & Secilmi, A. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.07.033 · Cited by 4
Vascular action of the crude hydroalcoholic extract from Hymenaea martiana on the isolated rat and rabbit aorta
Calixto, J. Β., Yunes, R. A., & Medeiros, Y. S. (1992) · Phytotherapy Research · doi:10.1002/ptr.2650060610 · Cited by 4
The analogous reaction of diSchiff base coordinated copper and Cu2Zn2 superoxide dismutase with nitric oxide
Deters, D., & Weser, U. (1995) · BioMetals · doi:10.1007/bf00156154 · Cited by 4
Prostacyclin, EDRF and Atherosclerosis
Moncada, S. (1988) · Advances in experimental medicine and biology · doi:10.1007/978-1-4613-0733-4_1 · Cited by 4
Self-citation
In vitro and in vivo effects of nitric oxide synthase inhibitors and nitric oxide inactivators on the South American opossum ileocolonic junction*
Matsuda, N. M., Feitosa, R. L., Lemos, M. C., de Oliveira, R. B., & Ballejo, G. (1998) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1998.00096.x · Cited by 4
Endothelium — Influenced Vasomotion: Models and Measurements
Griffith, T. M. (1989) · Springer eBooks · doi:10.1007/978-1-4684-7856-3_14 · Cited by 3
Anesthesia and Pathophysiology of Microcirculation
Kusza, K., Wawrzyniak, K., & Cywiński, J. B. (2010) · Springer eBooks · doi:10.1007/978-1-84882-513-0_50 · Cited by 2
Endothelium-Dependent Vasodilation and the Nature of the Endothelium-Derived Relaxing Factor
Furchgott, R. F. (1989) · Springer eBooks · doi:10.1007/978-1-4684-8532-5_21 · Cited by 2
Effects of hypoxia, mechanical and chemical endothelium denudation on guinea-pig isolated pulmonary arteries
Abdalla, S., & Will, J. A. (1995) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(94)00165-j · Cited by 2
Periodontitis
(2020) · MDPI eBooks · doi:10.3390/books978-3-03943-508-1 · Cited by 3
Endothelium-Derived Vasodilators
Moncada, S., Palmer, R. M. J., & Higgs, E. A. (1989) · Springer eBooks · doi:10.1007/978-1-4684-8532-5_22 · Cited by 2
Self-citation
The role of vascular endothelium in the modulation of coronary vasomotor tone
Kaski, J. C. (1996) · Developments in cardiovascular medicine · doi:10.1007/978-94-011-5406-2_5 · Cited by 2
Chronic changes of hematocrit value alter blood pressure and glomerular filtration in spontaneously hypertensive rats
Milanović, S., Jovović, D., Mihailovic‐Stanojevic, N., Grujić-Milanović, J. D., Ivanov, M., Karanović, D., & Miloradović, Z. (2012) · Acta veterinaria · doi:10.2298/avb1201027m · Cited by 1
Contractions induced by phenylephrine and noradrenaline are differently affected by endothelium-dependent relaxation in rat aorta
Auguet, M., Tricoche, R., & Braquet, P. G. (1992) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1992.tb03578.x · Cited by 1
Modeling the implications of nitric oxide dynamics on information transmission: An automata networks approach
Fernández-López, P., Báez, P. G., Cabrera-León, Y., Procházka, A., & Suárez-Araujo, C. P. (2023) · AIMS Mathematics · doi:10.3934/math.20231541 · Cited by 1
Volume Signaling and Neural-Indexing by Nitric Oxide in Artificial Neural Networks
Fernández-López, P., Báez, P. G., Cabrera-León, Y., Navarro-Mesa, J. L., & Suárez-Araujo, C. P. (2022) · IEEE Access · doi:10.1109/access.2022.3196672 · Cited by 1
The Relationship between Retinal Vascular Reactivity and Arteriolar Diameter
Tayyari, F. (2006) · UWSpace (University of Waterloo) · Cited by 1
Communications
(1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb16271.x · Cited by 1
Oxygen Radical Regulation of Vascular Reactivity
Thomas, G. R., & Ramwell, P. W. (1988) · Springer eBooks · doi:10.1007/978-3-642-73424-3_17
Le monoxyde d'azote. Aspects fondamentaux et perspectives thérapeutiques
Moutafis, M. (1996) · La Revue de Médecine Interne · doi:10.1016/0248-8663(96)83712-x
The role of oxygen free radicals in the destruction of endothelium-derived relaxing factor (EDRF)
Gryglewski, R. J. (1987) · Inflammation Research · doi:10.1007/bf02009073
Self-citation
Modulation of endothelium-dependent arterial relaxation by inorganic arsenic and glucose
Ellinsworth, D. C. (2010) · ORCA Online Research @Cardiff (Cardiff University)
Hypoxia-Induced Arteriolar Dilation and Endothelium-Derived Relaxing Factor in Normotensive and Hypertensive Rats
Alsip, N. L., Lübbe, A. S., & Harris, P. D. (1994) · Endothelium · doi:10.3109/10623329409024633

Authors: Moncada, S., Palmer, R. M., & Gryglewski, R. J.
ORCID: Moncada, S
Palmer, R M
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1986-12
Volume: 83
Issue: 23
Pages: 9164-9168
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.83.23.9164
PMC: PMC387095
OpenAlex: W2076583182
Cited by: 219
References: 20
Citations by year: 2025: 1 · 2023: 1 · 2022: 3 · 2020: 2 · 2019: 4 · 2018: 3 · 2016: 1 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 6
FWCI: 14.09
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords: endothelium-derived relaxing factor, nitric oxide, nitric oxide inhibitors, phenidone, BW755C, dithiothreitol, hydroquinone, pyrogallol, superoxide, superoxide dismutase, oxidized cytochrome c, vasorelaxation, porcine aortic endothelial cells, nitroglycerin
MeSH terms: Animals, Cytochrome c Group, Dithiothreitol, Endothelium, Hydroquinones, Muscle, Smooth, Vascular, Nitric Oxide, Oxidation-Reduction, Pyrazoles, Pyrogallol, Superoxide Dismutase, Swine, Vasodilator Agents, 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mechanism of action of some inhibitors of endothelium-derived relaxing factor

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks