The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.
Open accessAbstract
The Philadelphia chromosome is present in more than 95% of chronic myeloid leukemia patients and 13% of acute lymphocytic leukemia patients. The Philadelphia translocation, t(9;22), fuses the BCR and ABL genes resulting in the expression of leukemia-specific, chimeric BCR-ABL messenger RNAs. To facilitate diagnosis of these leukemias, we have developed a method of amplifying and detecting only the unique mRNA sequences, using an extension of the polymerase chain reaction technique. Diagnosis of chronic myeloid and acute lymphocytic leukemias by this procedure is rapid, much more sensitive than existing protocols, and independent of the presence or absence of an identifiable Philadelphia chromosome.
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Citations
Cites
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Cited by
Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray
Schena, M., Shalon, D., Davis, R. W., & Brown, P. O. (1995) · Science · doi:10.1126/science.270.5235.467 · Cited by 9,609
Kazuo, M., & Sumio, S. (1994) · Gene · doi:10.1016/0378-1119(94)90802-8 · Cited by 567
Biernaux, C., Loos, M., Sels, A., Huez, G., & Stryckmans, P. (1995) · Blood · doi:10.1182/blood.v86.8.3118.3118 · Cited by 485
Kawasaki, E. S. (1990) · PCR Protocols · doi:10.1016/b978-0-12-372180-8.50007-x · Cited by 474
Self-citationDowning, Jr., Head, D., Curcio-Brint, A., Hulshof, M., Motroni, T., Raimondi, S., Carroll, A., Drabkin, H., Willman, C., & Theil, K. (1993) · Blood · doi:10.1182/blood.v81.11.2860.2860 · Cited by 173
Metadata
- Authors
- Kawasaki, E. S., Clark, S. S., Coyne, M. Y., Smith, S. D., Champlin, R., Witte, O. N., & McCormick, F. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-08
- Volume
- 85
- Issue
- 15
- Pages
- 5698-5702
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2019215987
- Cited by
- 709
- References
- 33
- FWCI
- 38.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Kawasaki, E. S., Clark, S. S., Coyne, M. Y., Smith, S. D., Champlin, R., Witte, O. N., & McCormick, F. P. (1988). Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.15.5698
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
