The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications.
Open accessAbstract
Proteases that are encoded by animal picornaviruses and plant como- and potyviruses form a related group of cysteine-active-center enzymes that are essential for virus maturation. We show that these proteins are homologous to the family of trypsin-like serine proteases. In our model, the active-site nucleophile of the trypsin catalytic triad, Ser-195, is changed to a Cys residue in these viral proteases. The other two residues of the triad, His-57 and Asp-102, are otherwise absolutely conserved in all the viral protease sequences. Secondary structure analysis of aligned sequences suggests the location of the component strands of the twin beta-barrel trypsin fold in the viral proteases. Unexpectedly, the 2a and 3c subclasses of viral cysteine proteases are, respectively, homologous to the small and large structural subclasses of trypsin-like serine proteases. This classification allows the molecular mapping of residues from viral sequences onto related tertiary structures; we precisely identify amino acids that are strong determinants of specificity for both small and large viral cysteine proteases.
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Cited by
Structural design and molecular evolution of a cytokine receptor superfamily.
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Self-citationMolecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
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Equine arteritis virus is not a togavirus but belongs to the coronaviruslike superfamily
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Metadata
- Authors
- Bazan, J. F., & Fletterick, R. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-11
- Volume
- 85
- Issue
- 21
- Pages
- 7872-7876
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2121465721
- Cited by
- 422
- References
- 35
- FWCI
- 30.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Bazan, J. F., & Fletterick, R. J. (1988). Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.21.7872
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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