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Degranulation of human mast cells induces an endothelial antigen central to leukocyte adhesion.
Open accessAbstract
To understand better the role of mast cell secretory products in the genesis of inflammation, a system was developed for in vitro degranulation of human mast cells in skin organ cultures. Within 2 hr after morphine sulfate-induced degranulation, endothelial cells lining microvessels adjacent to affected mast cells expressed an activation antigen important for endothelial-leukocyte adhesion. Identical results were obtained when other mast cell secretagogues (anti-IgE, compound 48/80, and calcium ionophore A23187) were used. Induction of this antigen was abrogated by preincubation with cromolyn sodium, an inhibitor of mast cell secretion, and by antiserum to tumor necrosis factor alpha. These findings indicate that degranulation of mast cells activates dermal endothelium through tumor necrosis factor-dependent mechanisms. This event may be critical to the elicitation phase of cutaneous inflammation.
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Cited by
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882
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Gordon, J. R., & Galli, S. J. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.1.103 · Cited by 363
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Nickoloff, B. J. (1991) · Archives of Dermatology · doi:10.1001/archderm.127.6.871 · Cited by 344
Interstitial Cystitis: A Neuroimmunoendocrine Disorder a
THEOHARIDES, T. C., PANG, X., LETOURNEAU, R., & SANT, G. R. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb09601.x · Cited by 139
Metadata
- Authors
- Klein, L. M., Lavker, R. M., Matis, W. L., & Murphy, G. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-11
- Volume
- 86
- Issue
- 22
- Pages
- 8972-8976
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977986376
- Cited by
- 252
- References
- 0
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Degranulation of human mast cells induces an endothelial antigen central to leukocyte adhesion. https://app.cochat.ai/papers/10.1073/pnas.86.22.8972
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- Klein, L. M., Lavker, R. M., Matis, W. L., & Murphy, G. F. (1989). Degranulation of human mast cells induces an endothelial antigen central to leukocyte adhesion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.22.8972
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
