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Cited by 1,519

The DOI matches its Crossref record.

Low density lipoprotein undergoes oxidative modification in vivo.

Open access
Palinski, W, Rosenfeld, M E, Ylä-Herttuala, S, Gurtner, G C, Socher, S S, Butler, S W, Parthasarathy, S, Carew, T E, Steinberg, D, Witztum, J L·1989·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.86.4.1372
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Abstract

It has been proposed that low density lipoprotein (LDL) must undergo oxidative modification before it can give rise to foam cells, the key component of the fatty streak lesion of atherosclerosis. Oxidation of LDL probably generates a broad spectrum of conjugates between fragments of oxidized fatty acids and apolipoprotein B. We now present three mutually supportive lines of evidence for oxidation of LDL in vivo: (i) Antibodies against oxidized LDL, malondialdehyde-lysine, or 4-hydroxynonenal-lysine recognize materials in the atherosclerotic lesions of LDL receptor-deficient rabbits; (ii) LDL gently extracted from lesions of these rabbits is recognized by an antiserum against malondialdehyde-conjugated LDL; (iii) autoantibodies against malondialdehyde-LDL (titers from 512 to greater than 4096) can be demonstrated in rabbit and human sera.

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Metadata

Authors
Palinski, W., Rosenfeld, M. E., Ylä-Herttuala, S., Gurtner, G. C., Socher, S. S., Butler, S. W., Parthasarathy, S., Carew, T. E., Steinberg, D., & Witztum, J. L.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1989-02
Volume
86
Issue
4
Pages
1372-1376
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.86.4.1372
OpenAlex
W1968679020
Cited by
1,519
References
0
FWCI
29.63
Type
journal article
Language
en
Open access
green

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