Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E–deficient mice

Beyond Cholesterol

Epstein, F. H., Steinberg, D. I., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989) · New England Journal of Medicine · doi:10.1056/nejm198904063201407 · Cited by 6,425 · see citing works

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Plump, A. S., Smith, J. D., Hayek, T., Aalto-Setälä, K., Walsh, A., Verstuyft, J. G., Rubin, E. M., & Breslow, J. L. (1992) · Cell · doi:10.1016/0092-8674(92)90362-g · Cited by 2,263 · see citing works

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237 · see citing works

Book ReviewAmbulatory Pediatric Care

Steinberg, J. B. (1989) · New England Journal of Medicine · doi:10.1056/nejm198901053200122 · Cited by 2,121 · see citing works

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

Ylä‐Herttuala, S., Palinski, W., Rosenfeld, M. E., Parthasarathy, S., Carew, T. E., Butler, S. S., Witztum, J. L., & Steinberg, D. H. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114271 · Cited by 1,877 · see citing works

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

Nagy, L., Tontonoz, P., Alvarez, J. G. A., Chen, H.-W., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81574-3 · Cited by 1,861 · see citing works

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

Tontonoz, P., Nagy, L., Alvarez, J. G. A., Thomázy, V. A., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81575-5 · Cited by 1,800 · see citing works

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Nakashima, Y., Plump, A. S., Raines, E. W., Breslow, J. L., & Ross, R. (1994) · Arteriosclerosis and Thrombosis: A Journal of Vascular Biology · doi:10.1161/01.atv.14.1.133 · Cited by 1,693 · see citing works

Low Density Lipoprotein Oxidation and Its Pathobiological Significance

Steinberg, D. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.20963 · Cited by 1,643 · see citing works

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

Steinbrecher, U. P., Parthasarathy, S., Leake, D. S., Witztum, J. L., & Steinberg, D. I. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.12.3883 · Cited by 1,626 · see citing works

Low density lipoprotein undergoes oxidative modification in vivo.

Palinski, W., Rosenfeld, M. E., Ylä‐Herttuala, S., Gurtner, G. C., Socher, S. S., Butler, S. W., Parthasarathy, S., Carew, T. E., Steinberg, D. H., & Witztum, J. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.4.1372 · Cited by 1,514 · see citing works

The oxidation hypothesis of atherosclerosis

Witztum, J. L. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92346-9 · Cited by 1,394 · see citing works

The role of oxidized lipoproteins in atherogenesis

Berliner, J. A., & Heinecke, J. W. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02173-6 · Cited by 1,365 · see citing works

Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.

Cushing, S. D., Berliner, J. A., Valente, A. J., Territo, M., Navab, M., Parhami, F., Gerrity, R. G., Schwartz, C. J., & Fogelman, A. M. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.13.5134 · Cited by 1,147 · see citing works

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

Quinn, M. T., Parthasarathy, S., Fong, L. G., & Steinberg, D. I. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.9.2995 · Cited by 1,138 · see citing works

Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

Henriksen, T., Mahoney, E. M., & Steinberg, D. H. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.10.6499 · Cited by 1,024 · see citing works

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.

Morel, D. W., DiCorleto, P. E., & Chisolm, G. M. (1984) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.4.4.357 · Cited by 808 · see citing works

Structural Identification by Mass Spectrometry of Oxidized Phospholipids in Minimally Oxidized Low Density Lipoprotein That Induce Monocyte/Endothelial Interactions and Evidence for Their Presence in Vivo

Watson, A. D., Leitinger, N., Navab, M., Faull, K. F., Hörkkö, S., Witztum, J. L., Palinski, W., Schwenke, D., Salomon, R. G., Sha, W., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.21.13597 · Cited by 753 · see citing works

The Yin and Yang of Oxidation in the Development of the Fatty Streak

Navab, M., Berliner, J. A., Watson, A. D., Hama, S. Y., Territo, M., Lusis, A. J., Shih, D. M., Lenten, B. J. V., Frank, J. S., Demer, L. L., et al. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.7.831 · Cited by 699 · see citing works

Mammalian lipoxygenases: molecular structures and functions

Yamamoto, S. (1992) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(92)90297-9 · Cited by 572 · see citing works

Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.

Heinecke, J. W., Rosen, H., & Chait, A. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111609 · Cited by 536 · see citing works

Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice

Praticò, D., Tangirala, R. K., Rader, D. J., Rokach, J., & FitzGerald, G. A. (1998) · Nature Medicine · doi:10.1038/2685 · Cited by 501 · see citing works

ApoE-deficient mice are a model of lipoprotein oxidation in atherogenesis. Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum.

Palinski, W., Ord, V. A., Plump, A. S., Breslow, J. L., Steinberg, D. H., & Witztum, J. L. (1994) · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · doi:10.1161/01.atv.14.4.605 · Cited by 488 · see citing works

Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation

Linton, M. F., Atkinson, J. B., & Fazio, S. (1995) · Science · doi:10.1126/science.7863332 · Cited by 478 · see citing works

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.

Parthasarathy, S., Printz, D. J., Boyd, D. K., Joy, L. L., & Steinberg, D. H. (1986) · Arteriosclerosis An Official Journal of the American Heart Association Inc · doi:10.1161/01.atv.6.5.505 · Cited by 443 · see citing works

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions.

Ylä‐Herttuala, S., Rosenfeld, M. E., Parthasarathy, S., Glass, C. K., Sigal, E., Witztum, J. L., & Steinberg, D. H. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.18.6959 · Cited by 424 · see citing works

Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.

SParthasarathy, JPrintz, D., DBoyd, LJoy, & DSteinberg (1986) · Arteriosclerosis An Official Journal of the American Heart Association Inc · Cited by 416 · see citing works

A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

Parthasarathy, S., Wieland, E., & Steinberg, D. H. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.3.1046 · Cited by 415 · see citing works

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

Ylä‐Herttuala, S., Rosenfeld, M. E., Parthasarathy, S., Sigal, E., Särkioja, T., Witztum, J. L., & Steinberg, D. I. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115111 · Cited by 379 · see citing works

Specific inflammatory cytokines regulate the expression of human monocyte 15-lipoxygenase.

Conrad, D. J., Kühn, H., Mulkins, M. A., Highland, E., & Sigal, E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.217 · Cited by 379 · see citing works

Human Atherosclerotic Plaque Contains Both Oxidized Lipids and Relatively Large Amounts of α-Tocopherol and Ascorbate

Suarna, C., Dean, R. T., May, J. M., & Stocker, R. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.10.1616 · Cited by 356 · see citing works

Localization of distinct F2-isoprostanes in human atherosclerotic lesions.

Praticò, D., Iuliano, L., Mauriello, A., Spagnoli, L. G., Lawson, J. A., Rokach, J., Maclouf, J., Violi, F., & FitzGerald, G. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119735 · Cited by 344 · see citing works

Reduced uptake of oxidized low density lipoproteins in monocyte-derived macrophages from CD36-deficient subjects.

Nozaki, S., Kashiwagi, H., Yamashita, S., Nakagawa, T., Kostner, B., Tomiyama, Y., Nakata, A., Ishigami, M., Miyagawa, J.-I., & Kameda-Takemura, K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118231 · Cited by 340 · see citing works

Markers of mouse macrophage development detected by monoclonal antibodies

Leenen, P. J. M., Bruijn, M. F. T. R. D., Voerman, J. S. A., Campbell, P. A., & van Ewijk, W. (1994) · Journal of Immunological Methods · doi:10.1016/0022-1759(94)90005-1 · Cited by 332 · see citing works

The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice

Funk, C. D. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/s0005-2760(96)00107-5 · Cited by 267 · see citing works

Disruption of 12/15-Lipoxygenase Expression in Peritoneal Macrophages

Sun, D., & Funk, C. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.39.24055 · Cited by 256 · see citing works

Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques.

Folcik, V. A., Nivar-Aristy, R. A., Krajewski, L. P., & Cathcart, M. K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118062 · Cited by 252 · see citing works

Increased Autoantibody Titers Against Epitopes of Oxidized LDL in LDL Receptor–Deficient Mice With Increased Atherosclerosis

Palinski, W., Tangirala, R. K., Miller, E. R., Young, S. G., & Witztum, J. L. (1995) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.15.10.1569 · Cited by 239 · see citing works

Induction of 15-lipoxygenase by interleukin-13 in human blood monocytes.

Nassar, G. M., Morrow, J. D., Roberts, L. J., Lakkis, F. G., & Badr, K. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47031-7 · Cited by 234 · see citing works

Macrophage-mediated 15-lipoxygenase expression protects against atherosclerosis development.

Shen, J., Herderick, E. E., Cornhill, J. F., Zsigmond, E., Kim, H. S., Kühn, H., Guevara, J., & Chan, L. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119029 · Cited by 233 · see citing works

cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases.

Chen, X. S., Kurre, U., Jenkins, N. A., Copeland, N. G., & Funk, C. D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36743-1 · Cited by 227 · see citing works

IPF 2α -I: An index of lipid peroxidation in humans

Praticò, D., Barry, Ó. P., Lawson, J. A., Adiyaman, M., Hwang, S., Khanapure, S. P., Iuliano, L., Rokach, J., & FitzGerald, G. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3449 · Cited by 219 · see citing works

A primary determinant for lipoxygenase positional specificity

Sloane, D. L., Leung, R., Craik, C. S., & Sigal, E. (1991) · Nature · doi:10.1038/354149a0 · Cited by 207 · see citing works

Involvement of 15-lipoxygenase in early stages of atherogenesis.

Kühn, H., Belkner, J., Zaiss, S., Fährenklemper, T., & Wohlfeil, S. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.6.1903 · Cited by 193 · see citing works

Attenuation of diet‐induced atherosclerosis in rabbits with a highly selective 15‐lipoxygenase inhibitor lacking significant antioxidant properties

Sendobry, S. M., Cornicelli, J. A., Welch, K. A., Bocan, T. M. A., Tait, B. D., Trivedi, B. K., Colbry, N. L., Dyer, R. D., Feinmark, S. J., & Daugherty, A. (1997) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0701007 · Cited by 175 · see citing works

In vivo action of 15-lipoxygenase in early stages of human atherogenesis.

Kühn, H., Heydeck, D., Hugou, I., & Gniwotta, C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119253 · Cited by 168 · see citing works

Nomenclature of Isoprostanes: A Proposal

Rokach, J., KHANAPURE, S. P., Hwang, S., Adiyaman, M., Lawson, J. A., & FitzGerald, G. A. (1997) · Prostaglandins · doi:10.1016/s0090-6980(97)00184-6 · Cited by 144 · see citing works

The epitopes for some antiphospholipid antibodies are adducts of oxidized phospholipid and β 2 glycoprotein 1 (and other proteins)

Hörkkö, S., Miller, E. R., Branch, D. W., Palinski, W., & Witztum, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.19.10356 · Cited by 138 · see citing works

Deaths: final data for 1996.

Peters, K. D., Kochanek, K. D., & Murphy, S. L. (1998) · PubMed · Cited by 134 · see citing works

Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities

Kühn, H., Belkner, J., Suzuki, H., & Yamamoto, S. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39770-4 · Cited by 132 · see citing works

Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein.

Ylä‐Herttuala, S., Luoma, J., Viita, H., Hiltunen, T. P., Sisto, T., & Nikkari, T. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117971 · Cited by 129 · see citing works

A specific 15-lipoxygenase inhibitor limits the progression and monocyte–macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit

Bocan, T. M. A., Rosebury, W. S., Mueller, S. B., Kuchera, S. L., Welch, K. A., Daugherty, A., & Cornicelli, J. A. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(97)00204-9 · Cited by 115 · see citing works

The Rabbit 15-Lipoxygenase Preferentially Oxygenates LDL Cholesterol Esters, and This Reaction Does Not Require Vitamin E

Belkner, J., STENDER, H., & Kühn, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.36.23225 · Cited by 112 · see citing works

Enhanced Levels of Lipoperoxides in Low Density Lipoprotein Incubated with Murine Fibroblasts Expressing High Levels of Human 15-Lipoxygenase

Benz, D., Mol, M. J. T. M., Ezaki, M., Mori-Ito, N., Zelán, I., Miyanohara, A., Friedmann, T., Parthasarathy, S., Steinberg, D. H., & Witztum, J. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5191 · Cited by 107 · see citing works

The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions

Hartmut, K., & Chan, L. (1997) · Current Opinion in Lipidology · doi:10.1097/00041433-199704000-00009 · Cited by 99 · see citing works

Phenylalanine 353 is a Primary Determinant for the Positional Specificity of Mammalian 15-Lipoxygenases

Borngräber, S., Kuban, R., Anton, M., & Kühn, H. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0702 · Cited by 93 · see citing works

Investigation of the oxygenation of phospholipids by the porcine leukocyte and human platelet arachidonate 12‐lipoxygenases

Takahashi, Y., Glasgow, W. C., Suzuki, H., Taketani, Y., Yamamoto, S., Anton, M., Kühn, H., & BRASH, A. R. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18362.x · Cited by 89 · see citing works

Cytokine Modulation of LDL Oxidation by Activated Human Monocytes

Folcik, V. A., Aamir, R., & Cathcart, M. K. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.10.1954 · Cited by 79 · see citing works

Induction of 15-Lipoxygenase mRNA and Protein in Early Atherosclerotic Lesions

Hiltunen, T. P., Luoma, J. S., Nikkari, T., & Ylä‐Herttuala, S. (1995) · Circulation · doi:10.1161/01.cir.92.11.3297 · Cited by 72 · see citing works

Fibroblasts That Overexpress 15-Lipoxygenase Generate Bioactive and Minimally Modified LDL

Sigari, F., Lee, C., Witztum, J. L., & Reaven, P. D. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.12.3639 · Cited by 70 · see citing works

Lipoperoxides in LDL incubated with fibroblasts that overexpress 15-lipoxygenase.

Ezaki, M., Witztum, J. L., & Steinberg, D. H. (1995) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41117-4 · Cited by 64 · see citing works

Is there a role for 15-lipoxygenase in atherogenesis?

Feinmark, S. J., & Cornicelli, J. A. (1997) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00135-4 · Cited by 38 · see citing works

Occurrence of the erythroid cell specific arachidonate 15-lipoxygenase in human reticulocytes

Kroschwald, P., Kroschwald, A., ̈hn, H. K., Ludwig, P., Thiele, B. J., ̈hne, M. H., SCHEWE, T., & Rapoport, S. M. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92528-x · Cited by 34 · see citing works

Atherosclerosis

Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,880 · see citing works

Atherosclerosis

Glass, C. K., & Witztum, J. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00238-0 · Cited by 3,049 · see citing works

Role of Oxidative Modifications in Atherosclerosis

Stocker, R., & Keaney, J. F. (2004) · Physiological Reviews · doi:10.1152/physrev.00047.2003 · Cited by 2,611 · see citing works

Oxidative Stress and Vascular Disease

Madamanchi, N. R., Vendrov, A., & Runge, M. S. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000150649.39934.13 · Cited by 1,618 · see citing works

Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis

Förstermann, U., Xia, N., & Li, H. (2017) · Circulation Research · doi:10.1161/circresaha.116.309326 · Cited by 1,519 · see citing works

Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

Wang, B., Wu, L., Chen, J., Dong, L., Chen, C., Zheng, W., Hu, J., Fleming, I., & Wang, D. W. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00443-w · Cited by 1,467 · see citing works

Immune and Inflammatory Mechanisms of Atherosclerosis

Galkina, E., & Ley, K. F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132620 · Cited by 1,446 · see citing works

Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice

Febbraio, M., Podrez, E. A., Smith, J. D., Hajjar, D. P., Hazen, S. L., Hoff, H. F., Sharma, K., & Silverstein, R. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9259 · Cited by 1,037 · see citing works

Oxidative Stress and Cardiovascular Injury

Griendling, K. K., & FitzGerald, G. A. (2003) · Circulation · doi:10.1161/01.cir.0000093660.86242.bb · Cited by 940 · see citing works

Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease

Haeggström, J. Z., & Funk, C. D. (2011) · Chemical Reviews · doi:10.1021/cr200246d · Cited by 875 · see citing works

Reactive oxygen species in cardiovascular disease

Sugamura, K., & Keaney (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.004 · Cited by 769 · see citing works

The oxidative modification hypothesis of atherogenesis: an overview

Chisolm, G. M., & Steinberg, D. H. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00344-0 · Cited by 742 · see citing works

Oxidative Stress and Cardiovascular Injury

Griendling, K. K., & FitzGerald, G. A. (2003) · Circulation · doi:10.1161/01.cir.0000093661.90582.c4 · Cited by 720 · see citing works

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

Lillis, A. P., Duyn, L. B. V., Murphy-Ullrich, J. E., & Strickland, D. K. (2008) · Physiological Reviews · doi:10.1152/physrev.00033.2007 · Cited by 702 · see citing works

The macrophage foam cell as a target for therapeutic intervention

Li, A. C., & Glass, C. K. (2002) · Nature Medicine · doi:10.1038/nm1102-1235 · Cited by 700 · see citing works

Thematic review series: The Pathogenesis of Atherosclerosis The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL

Navab, M., Ananthramaiah, G. M., Reddy, S. T., Lenten, B. J. V., Ansell, B. J., Fonarow, G. C., Vahabzadeh, K., Hama, S. Y., Hough, G., Kamranpour, N., et al. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400001-jlr200 · Cited by 687 · see citing works

Normal high density lipoprotein inhibits three steps in the formation of mildly oxidized low density lipoprotein: steps 2 and 3

Navab, M., Hama, S. Y., Anantharamaiah, G. M., Hassan, K., Hough, G. P., Watson, A. D., Reddy, S. T., Sevanian, A., Fonarow, G. C., & Fogelman, A. M. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33462-3 · Cited by 663 · see citing works

Mammalian lipoxygenases and their biological relevance

Kühn, H., Banthiya, S., & van Leyen, K. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.10.002 · Cited by 629 · see citing works

Synopsis of arachidonic acid metabolism: A review

Hanna, V. S., & HAFEZ, E. A. A. (2018) · Journal of Advanced Research · doi:10.1016/j.jare.2018.03.005 · Cited by 595 · see citing works

Site Specificity of Atherosclerosis

VanderLaan, P. A., Reardon, C. A., & Getz, G. S. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000105054.43931.f0 · Cited by 570 · see citing works

Monocyte and Macrophage Dynamics During Atherogenesis

Ley, K. F., Miller, Y. I., & Hedrick, C. C. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.221127 · Cited by 553 · see citing works

Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works

Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model

Kasahara, K., Krautkramer, K. A., Org, E., Romano, K. A., Kerby, R. L., Vivas, E. I., Mehrabian, M., Denu, J. M., Bäckhed, F., Lusis, A. J., et al. (2018) · Nature Microbiology · doi:10.1038/s41564-018-0272-x · Cited by 537 · see citing works

The Role of Oxidative Stress in Diabetic Complications

Niedowicz, D. M., & Daleke, D. L. (2005) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:43:2:289 · Cited by 528 · see citing works

Oxidative stress and atherosclerosis

Singh, U. S., & Jialal, I. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.002 · Cited by 492 · see citing works

Is the Oxidative Modification Hypothesis Relevant to Human Atherosclerosis?

Steinberg, D. H., & Witztum, J. L. (2002) · Circulation · doi:10.1161/01.cir.0000014762.06201.06 · Cited by 471 · see citing works

Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis

Spanbroek, R., Gräbner, R., Lötzer, K., Hildner, M., Urbach, A., Rühling, K., Moos, M. P. W., Kaiser, B., Cohnert, T. U., Wahlers, T., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242716099 · Cited by 457 · see citing works

Molecular Biology of Atherosclerosis

Hopkins, P. N. (2013) · Physiological Reviews · doi:10.1152/physrev.00004.2012 · Cited by 456 · see citing works

The LDL modification hypothesis of atherogenesis: an update

Steinberg, D. H. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800087-jlr200 · Cited by 452 · see citing works

HDL and the Inflammatory Response Induced by LDL-Derived Oxidized Phospholipids

Navab, M., Berliner, J. A., Subbanagounder, G., Hama, S. Y., Lusis, A. J., Castellani, L. W., Reddy, S. T., Shih, D. M., Shi, W., Watson, A. D., et al. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.4.481 · Cited by 441 · see citing works

The Oxidative Modification Hypothesis of Atherosclerosis Does It Hold for Humans?

Witztum, J. L. (2001) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(01)00111-6 · Cited by 441 · see citing works

Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases

Sonnweber, T., Pizzini, A., Nairz, M., Weiß, G., & Tancevski, I. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113285 · Cited by 439 · see citing works

Autoimmune and Inflammatory Mechanisms in Atherosclerosis

Wick, G., Knoflach, M., & Xu, Q. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104644 · Cited by 428 · see citing works

Combined Serum Paraoxonase Knockout/Apolipoprotein E Knockout Mice Exhibit Increased Lipoprotein Oxidation and Atherosclerosis

Shih, D. M., Xia, Y.-R., Wang, X.-P., Miller, E. R., Castellani, L. W., Subbanagounder, G., Cheroutre, H., Faull, K. F., Berliner, J. A., Witztum, J. L., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910376199 · Cited by 423 · see citing works

The role of lipoxygenases in pathophysiology; new insights and future perspectives

Mashima, R., & Okuyama, T. (2015) · Redox Biology · doi:10.1016/j.redox.2015.08.006 · Cited by 421 · see citing works

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

Fredman, G., Hellmann, J., Proto, J. D., Kuriakose, G., Colas, R. A., Dorweiler, B., Connolly, E. S., Solomon, R., Jones, D. M., Heyer, E. J., et al. (2016) · Nature Communications · doi:10.1038/ncomms12859 · Cited by 411 · see citing works

Oxidized LDL and HDL: antagonists in atherothrombosis

Mertens, A. C., & Holvoet, P. (2001) · The FASEB Journal · doi:10.1096/fj.01-0273rev · Cited by 410 · see citing works

Role of Monocytes in Atherogenesis

Østerud, B., & Bjørklid, E. (2003) · Physiological Reviews · doi:10.1152/physrev.00005.2003 · Cited by 408 · see citing works

Inflammation and immune regulation by 12/15-lipoxygenases

Kühn, H., & O’Donnell, V. B. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.02.003 · Cited by 399 · see citing works

Nitric Oxide Is a Physiological Substrate for Mammalian Peroxidases

Abu‐Soud, H. M., & Hazen, S. L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.48.37524 · Cited by 398 · see citing works

New Insights into the Role of Inflammation in the Pathogenesis of Atherosclerosis

Wu, M., Li, C., Hou, M., & Chu, P. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102034 · Cited by 397 · see citing works

Oxidation of LDL by Myeloperoxidase and Reactive Nitrogen Species

Carr, A. C., McCall, M. R., & Frei, B. B. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.7.1716 · Cited by 392 · see citing works

Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis

Poznyak, A. V., Nikiforov, N. G., Markin, A. M., Kashirskikh, D. A., Myasoedova, V. A., Владимировна, Г. Е., & Orekhov, A. N. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.613780 · Cited by 379 · see citing works

Peroxisome proliferator‐activated receptors in the cardiovascular system

Bishop‐Bailey, D. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703149 · Cited by 358 · see citing works

Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies

Singh, N. K., & Rao, G. N. (2018) · Progress in Lipid Research · doi:10.1016/j.plipres.2018.11.001 · Cited by 348 · see citing works

Inhibition of 15-lipoxygenases by flavonoids: structure–activity relations and mode of action

Sadik, C. D., Sies, H., & SCHEWE, T. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01621-0 · Cited by 339 · see citing works

Role of Oxidative Stress in the Pathogenesis of Abdominal Aortic Aneurysms

McCormick, M. L., Gavrila, D., & Weintraub, N. L. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000257552.94483.14 · Cited by 337 · see citing works

Oxidative stress and cardiovascular disease: Novel tools give (free) radical insight

Fearon, I. M., & Faux, S. P. (2009) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2009.05.013 · Cited by 330 · see citing works

The Relevance of Mouse Models for Investigating Age-Related Bone Loss in Humans

Jilka, R. L. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt046 · Cited by 329 · see citing works

Leukotriene modifiers as potential therapeutics for cardiovascular disease

Funk, C. D. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1796 · Cited by 325 · see citing works

Functional and pathological roles of the 12- and 15-lipoxygenases

Dobrian, A. D., Lieb, D. C., Cole, B. K., Taylor, D., Chakrabarti, S. K., & Nadler, J. L. (2010) · Progress in Lipid Research · doi:10.1016/j.plipres.2010.10.005 · Cited by 324 · see citing works

Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid

Powell, W. S., & Rokach, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.10.008 · Cited by 322 · see citing works

The Role of Oxidized Low-Density Lipoproteins in Atherosclerosis: The Myths and the Facts

Maiolino, G., Rossitto, G., Caielli, P., Bisogni, V., Rossi, G. P., & Calò, L. A. (2013) · Mediators of Inflammation · doi:10.1155/2013/714653 · Cited by 315 · see citing works

A Role for the Mouse 12/15-Lipoxygenase Pathway in Promoting Epithelial Wound Healing and Host Defense

Gronert, K., Maheshwari, N., Khan, N. A., Hassan, I., Dunn, M. W., & Schwartzman, M. L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m410638200 · Cited by 308 · see citing works

Macrophage Differentiation to Foam Cells

Shashkin, P. N., Dragulev, B. P., & Ley, K. F. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612054865064 · Cited by 291 · see citing works

Role for Peroxisome Proliferator-Activated Receptor α in Oxidized Phospholipid–Induced Synthesis of Monocyte Chemotactic Protein-1 and Interleukin-8 by Endothelial Cells

Lee, H., Shi, W., Tontonoz, P., Wang, S., Subbanagounder, G., Hedrick, C. C., Hama, S. Y., Borromeo, C. M., Evans, R. M., Berliner, J. A., et al. (2000) · Circulation Research · doi:10.1161/01.res.87.6.516 · Cited by 291 · see citing works

Role of oxidative stress and nitric oxide in atherothrombosis

Lubos, E. (2008) · Frontiers in bioscience · doi:10.2741/3084 · Cited by 290 · see citing works

Mechanisms of LDL oxidation

Yoshida, H., & Kisugi, R. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.08.038 · Cited by 289 · see citing works

Interleukin-4 Deficiency Decreases Atherosclerotic Lesion Formation in a Site-Specific Manner in Female LDL Receptor−/− Mice

King, V. L., Szilvassy, S. J., & Daugherty, A. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0302.104905 · Cited by 265 · see citing works

Interactions Between Nitric Oxide and Lipid Oxidation Pathways: Implications for Vascular Disease

O’Donnell, V. B., & Freeman, B. A. (2001) · Circulation Research · doi:10.1161/01.res.88.1.12 · Cited by 257 · see citing works

The vulnerable atherosclerotic plaque

Aikawa, M., & Libby, P. (2004) · Cardiovascular Pathology · doi:10.1016/s1054-8807(04)00004-3 · Cited by 242 · see citing works

Protective Role of Uncoupling Protein 2 in Atherosclerosis

Blanc, J., Alves‐Guerra, M., Esposito, B., Rousset, S., Gourdy, P., Ricquier, D., Tedgui, A., Miroux, B., & Mallat, Z. (2003) · Circulation · doi:10.1161/01.cir.0000051722.66074.60 · Cited by 239 · see citing works

Overexpression of 15-Lipoxygenase in Vascular Endothelium Accelerates Early Atherosclerosis in LDL Receptor–Deficient Mice

Harats, D., Shaish, A., George, J., Mulkins, M. A., Kurihara, H., Levkovitz, H., & Sigal, E. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.9.2100 · Cited by 237 · see citing works

12/15-Lipoxygenase Orchestrates the Clearance of Apoptotic Cells and Maintains Immunologic Tolerance

Uderhardt, S., i, M. H., Oskolkova, O., Aschermann, S., Bicker, W., Ipseiz, N., Sarter, K., Frey, B., Rothe, T., Voll, R. E., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.010 · Cited by 235 · see citing works

Lipid Inflammatory Mediators in Diabetic Vascular Disease

Natarajan, R. D., & Nadler, J. L. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000133606.69732.4c · Cited by 232 · see citing works

Absence of 12/15-Lipoxygenase Expression Decreases Lipid Peroxidation and Atherogenesis in Apolipoprotein E–Deficient Mice

Cyrus, T., Praticò, D., Zhao, L., Witztum, J. L., Rader, D. J., Rokach, J., FitzGerald, G. A., & Funk, C. D. (2001) · Circulation · doi:10.1161/01.cir.103.18.2277 · Cited by 231 · see citing works

The rise of antioxidant signaling—The evolution and hormetic actions of Nrf2

Maher, J. M., & Yamamoto, M. P. (2010) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2010.01.011 · Cited by 231 · see citing works

Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)

Ivanov, I., Kühn, H., & Heydeck, D. (2015) · Gene · doi:10.1016/j.gene.2015.07.073 · Cited by 223 · see citing works

PPARs and lipid ligands in inflammation and metabolism

Harmon, G. S., Lam, M. T., & Glass, C. K. (2011) · Chemical Reviews · doi:10.1021/cr2001355 · Cited by 216 · see citing works

Oxidative risk for atherothrombotic cardiovascular disease

Leopold, J. A., & Loscalzo, J. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.09.009 · Cited by 216 · see citing works

Oxidative stress in atherogenesis and arterial thrombosis: the disconnect between cellular studies and clinical outcomes

Madamanchi, N. R., Hakim, Z. S., & Runge, M. S. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2004.01085.x · Cited by 212 · see citing works

Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells

Chen, C., Jiang, J. H., Lü, J.-M., Chai, H., Wang, X., Lin, P. H., & Yao, Q. C. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00431.2009 · Cited by 210 · see citing works

Lipid Lowering Reduces Oxidative Stress and Endothelial Cell Activation in Rabbit Atheroma

Aikawa, M., Sugiyama, S., Hill, C. C., Voglic, S. J., Aikawa, E. R., Fukumoto, Y., Schöen, F. J., Witztum, J. L., & Libby, P. (2002) · Circulation · doi:10.1161/01.cir.0000028465.52694.9b · Cited by 205 · see citing works

Identification of Immune Responses Against Aldehyde-Modified Peptide Sequences in ApoB Associated With Cardiovascular Disease

Fredrikson, G. N., Hedblad, B., Berglund, G. L., Alm, R., Ares, M. P. S., Cercek, B., Chyu, K., Shah, P. K., & Nilsson, J. Å. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000067935.02679.b0 · Cited by 203 · see citing works

Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators—What is the Evidence so far?

Schebb, N. H., Kühn, H., Kahnt, A. S., Rund, K. M., O’Donnell, V. B., Flamand, N., Peters-Golden, M. L., Jakobsson, P., Weylandt, K. H., Rohwer, N., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.838782 · Cited by 202 · see citing works

Lipoxygenase Pathways in Atherogenesis

Zhao, L., & Funk, C. D. (2004) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2004.04.003 · Cited by 199 · see citing works

Mammalian arachidonate 15-lipoxygenases

Kühn, H., Walther, M., & Kuban, R. J. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00035-7 · Cited by 197 · see citing works

Critical Role of Macrophage 12/15-Lipoxygenase for Atherosclerosis in Apolipoprotein E–Deficient Mice

Huo, Y., Zhao, L., Hyman, M. C., Shashkin, P. N., Harry, B. L., Burcin, T. L., Forlow, S. B., Stark, M. A., Smith, D. F., Clarke, S., et al. (2004) · Circulation · doi:10.1161/01.cir.0000143628.37680.f6 · Cited by 197 · see citing works

The effects of oxidative stress on the development of atherosclerosis

Khosravi, M., Poursaleh, A., Ghasempour, G., Shaikhnia, F., & Najafi, M. (2018) · Biological Chemistry · doi:10.1515/hsz-2018-0397 · Cited by 195 · see citing works

12/15-Lipoxygenase Gene Disruption Attenuates Atherogenesis in LDL Receptor–Deficient Mice

George, J., Afek, A. B., Shaish, A., Levkovitz, H., Bloom, N., Cyrus, T., Zhao, L., Funk, C. D., Sigal, E., & Harats, D. (2001) · Circulation · doi:10.1161/hc3901.095772 · Cited by 194 · see citing works

Oxidants and antioxidants in atherogenesis: an appraisal

Parthasarathy, S., Santanam, N., Ramachandran, S., & Meilhac, O. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32089-7 · Cited by 194 · see citing works

Lipoxygenase genes and their targeted disruption

Funk, C. D., Chen, X., Johnson, E. N., & Zhao, L. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00036-9 · Cited by 193 · see citing works

Multifunctional roles of macrophages in the development and progression of atherosclerosis in humans and experimental animals

Takahashi, K. I., Takeya, M., & Sakashita, N. (2002) · Medical Molecular Morphology · doi:10.1007/s007950200023 · Cited by 192 · see citing works

Chronic Inflammatory Diseases and Endothelial Dysfunction

Castellon, X., & Bogdanova, V. (2016) · Aging and disease · doi:10.14336/ad.2015.0803 · Cited by 191 · see citing works

New insights on oxidative stress in the artery wall

STOCKER, R., & KEANEY, J. F. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01370.x · Cited by 188 · see citing works

The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease

Poeckel, D., & Funk, C. D. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq016 · Cited by 185 · see citing works

Eicosanoid regulation of the renal vasculature

Imig, J. D. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.279.6.f965 · Cited by 183 · see citing works

Inhibitors of 15-Lipoxygenase from Orange Peel

Malterud, K. E., & Rydland, K. M. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf000613v · Cited by 181 · see citing works

Transgenic rabbits as therapeutic protein bioreactors and human disease models

Fan, J., & Watanabe, T. (2003) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(03)00069-x · Cited by 176 · see citing works

The Oxidation of Lipoproteins by Monocytes-Macrophages

Chisolm, G. M., Hazen, S. L., Fox, P. L., & Cathcart, M. K. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.25959 · Cited by 174 · see citing works

Mammalian Arachidonate 12-Lipoxygenases

Yamamoto, S., Takahashi, Y., Hada, T., Hagiya, H., Suzuki, H., Reddy, G. R., Ueda, N., Arakawa, T., Nakamura, M., Matsuda, S., et al. (1997) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-5325-0_18 · Cited by 173 · see citing works

Dietary Polyunsaturated Fatty Acids and Inflammation: The Role of Phospholipid Biosynthesis

Raphael, W., & Sordillo, L. M. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141021167 · Cited by 173 · see citing works

Adipocyte Fatty Acid–Binding Protein, aP2, Alters Late Atherosclerotic Lesion Formation in Severe Hypercholesterolemia

Boord, J. B., Maeda, K., Makowski, L., Babaev, V. R., Fazio, S., Linton, M. F., & Hotamışlıgil, G. S. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000033090.81345.e6 · Cited by 172 · see citing works

Monocyte tissue factor–dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin

Owens, A. P., Passam, F. H., Antoniak, S., Marshall, S., McDaniel, A. L., Rudel, L. L., Williams, J., Hubbard, B. K., Dutton, J., Wang, J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58969 · Cited by 171 · see citing works

Immunological responses to oxidized LDL

Hörkkö, S., Binder, C. J., Shaw, P. X., Chang, M.-K., Silverman, G. J., Palinski, W., & Witztum, J. L. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00333-6 · Cited by 171 · see citing works

Genetic Modifiers of Atherosclerosis in Mice

Knowles, J. W., & Maeda, N. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.11.2336 · Cited by 171 · see citing works

Physiologic and pathophysiologic roles of lipid mediators in the kidney

Hao, C., & Breyer, M. D. (2007) · Kidney International · doi:10.1038/sj.ki.5002192 · Cited by 167 · see citing works

The two faces of the 15-lipoxygenase in atherosclerosis

Wittwer, J., & Hersberger, M. (2007) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2007.08.001 · Cited by 166 · see citing works

The SYK side of TLR4: signalling mechanisms in response to LPS and minimally oxidized LDL

Miller, Y. I., Choi, S., Wiesner, P., & Bae, Y. S. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02097.x · Cited by 164 · see citing works

12/15-Lipoxygenase Counteracts Inflammation and Tissue Damage in Arthritis

Krönke, G., Katzenbeisser, J., Uderhardt, S., Zaiss, M. M., Scholtysek, C., Schabbauer, G., Zarbock, A., Koenders, M. I., Axmann, R., Zwerina, J., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900327 · Cited by 163 · see citing works

Absence of 12/15-Lipoxygenase Expression Decreases Lipid Peroxidation and Atherogenesis in Apolipoprotein E–Deficient Mice

Cyrus, T., Praticò, D., Zhao, L., Witztum, J. L., Rader, D. J., Rokach, J., FitzGerald, G. A., & Funk, C. D. (2001) · Circulation · doi:10.1161/01.cir.103.18.2277 · Cited by 231 · see citing works

Critical Role of Macrophage 12/15-Lipoxygenase for Atherosclerosis in Apolipoprotein E–Deficient Mice

Harry, B. L., Funk, C. D., & Ley, K. F. (2014)

12/15-Lipoxygenase Gene Disruption Attenuates Atherogenesis in LDL Receptor–Deficient Mice

George, J., Afek, A. B., Shaish, A., Levkovitz, H., Bloom, N., Cyrus, T., Zhao, L., Funk, C. D., Sigal, E., & Harats, D. (2001) · Circulation · doi:10.1161/hc3901.095772 · Cited by 194 · see citing works

12/15-Lipoxygenase gene disruption and Vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway

Zhao, L., Praticò, D., Rader, D. J., & Funk, C. D. (2005) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2005.07.003 · Cited by 37 · see citing works

Selective Interleukin-12 Synthesis Defect in 12/15-Lipoxygenase-deficient Macrophages Associated with Reduced Atherosclerosis in a Mouse Model of Familial Hypercholesterolemia

Zhao, L., Cuff, C. A., Moss, E., Wille, U., Cyrus, T., Klein, E. A., Praticò, D., Rader, D. J., Hunter, C. A., Puré, E., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205738200 · Cited by 102 · see citing works