The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes.
Open accessAbstract
We have identified an erythroid-specific enhancer element far upstream of the human "beta-like globin" genes, at 10.2-11.0 kilobases 5' of the embryonic epsilon-globin gene, and thus at 53-54 kilobases 5' of the adult beta-globin gene. It is capable of enhancing the expression of a cis-linked test gene by up to 300-fold. This enhancer element is apparently developmental-stage-independent, as it is functional at the embryonic and the adult developmental stages in erythroid cells that are expressing the respective beta-like globin genes. The enhancer and globin promoter sequences work in synergy and are capable of conferring on a cis-linked gene the high transcriptional efficiency (enhancer function), erythroid specificity (enhancer and promoter functions), and developmental-stage specificity (promoter function) that are characteristic of the in vivo transcription of the beta-like globin genes in erythroid cells.
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Cites
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Cited by
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What is a gene, post-ENCODE? History and updated definition
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Defining functional DNA elements in the human genome
Kellis, M., Wold, B., Snyder, M. P., Bernstein, B. E., Kundaje, A., Marinov, G. K., Ward, L. D., Birney, E., Crawford, G. E., Dekker, J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318948111 · Cited by 696
Long-range chromatin regulatory interactions in vivo
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Erythroid transcription factor NF-E2 is a haematopoietic-specific basic–leucine zipper protein
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Metadata
- Authors
- Tuan, D. Y., Solomon, W. B., London, I. M., & Lee, D. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-04
- Volume
- 86
- Issue
- 8
- Pages
- 2554-2558
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1974858651
- Cited by
- 277
- References
- 33
- FWCI
- 8.56
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes. https://app.cochat.ai/papers/10.1073/pnas.86.8.2554
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- Tuan, D. Y., Solomon, W. B., London, I. M., & Lee, D. P. (1989). An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "beta-like globin" genes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.8.2554
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