The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Nature's chemicals and synthetic chemicals: comparative toxicology.
Open accessAbstract
The toxicology of synthetic chemicals is compared to that of natural chemicals, which represent the vast bulk of the chemicals to which humans are exposed. It is argued that animals have a broad array of inducible general defenses to combat the changing array of toxic chemicals in plant food (nature's pesticides) and that these defenses are effective against both natural and synthetic toxins. Synthetic toxins such as dioxin are compared to natural chemicals, such as indole carbinol (in broccoli) and ethanol. Trade-offs between synthetic and natural pesticides are discussed. The finding that in high-dose tests, a high proportion of both natural and synthetic chemicals are carcinogens, mutagens, teratogens, and clastogens (30-50% for each group) undermines current regulatory efforts to protect public health from synthetic chemicals based on these tests.
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Cites
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Cited by
SHEEHAN, D., MEADE, G., FOLEY, V. M., & DOWD, C. A. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3600001 · Cited by 3,057
Schinkel, A. H., Smit, J. J. M., van Tellingen, O., Beijnen, J. H., Wagenaar, E., van Deemter, L., Mol, C. A. A. M., van der Valk, M. A., Robanus-Maandag, E. C., te Riele, H. P. J., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90212-7 · Cited by 2,281
Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes
Deponte, M. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.09.018 · Cited by 1,105
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Reactions and significance of cytochrome P-450 enzymes
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Metadata
- Authors
- Ames, B. N., Profet, M., & Gold, L. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-10
- Volume
- 87
- Issue
- 19
- Pages
- 7782-7786
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2025836436
- Cited by
- 275
- References
- 31
- FWCI
- 9.99
- Type
- journal article
- Language
- en
- Open access
- green
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- Ames, B. N., Profet, M., & Gold, L. S. (1990). Nature's chemicals and synthetic chemicals: comparative toxicology. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.19.7782
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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