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Cited by 447

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Gender differences in age effect on brain atrophy measured by magnetic resonance imaging.

Open access
Gur, R C, Mozley, P D, Resnick, S M, Gottlieb, G L, Kohn, M, Zimmerman, R, Herman, G, Atlas, S, Grossman, R, Berretta, D·1991·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.88.7.2845
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Abstract

A prospective sample of 69 healthy adults, age range 18-80 years, was studied with magnetic resonance imaging scans (T2 weighted, 5 mm thick) of the entire cranium. Volumes were obtained by a segmentation algorithm that uses proton density and T2 pixel values to correct field inhomogeneities ("shading"). Average (+/- SD) brain volume, excluding cerebellum, was 1090.91 ml (+/- 114.30; range, 822.19-1363.66), and cerebrospinal fluid (CSF) volume was 127.91 ml (+/- 57.62; range, 34.00-297.02). Brain volume was higher (by 5 ml) in the right hemisphere (P less than 0.0001). Men (n = 34) had 91 ml higher brain and 20 ml higher CSF volume than women (n = 35). Age was negatively correlated with brain volume [r(67) = -0.32, P less than 0.01] and positively correlated with CSF volume (r = 0.74, P less than 0.0001). The slope of the regression line with age for CSF was steeper for men than women (P = 0.03). This difference in slopes was significant for sulcal (P less than 0.0001), but not ventricular, CSF. The greatest amount of atrophy in elderly men was in the left hemisphere, whereas in women age effects were symmetric. The findings may point to neuroanatomic substrates of hemispheric specialization and gender differences in age-related changes in brain function. They suggest that women are less vulnerable to age-related changes in mental abilities, whereas men are particularly susceptible to aging effects on left hemispheric functions.

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Metadata

Authors
Gur, R. C., Mozley, P. D., Resnick, S. M., Gottlieb, G. L., Kohn, M., Zimmerman, R., Herman, G., Atlas, S., Grossman, R., & Berretta, D.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1991-04
Volume
88
Issue
7
Pages
2845-2849
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.88.7.2845
OpenAlex
W2056965030
Cited by
447
References
25
FWCI
10.68
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Gender differences in age effect on brain atrophy measured by magnetic resonance imaging. https://app.cochat.ai/papers/10.1073/pnas.88.7.2845
The paper
Gur, R. C., Mozley, P. D., Resnick, S. M., Gottlieb, G. L., Kohn, M., Zimmerman, R., Herman, G., Atlas, S., Grossman, R., & Berretta, D. (1991). Gender differences in age effect on brain atrophy measured by magnetic resonance imaging. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.7.2845

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.