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Cited by 297

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice.

Open access
Merrill, J E, Kono, D H, Clayton, J, Ando, D G, Hinton, D R, Hofman, F M·1992·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.89.2.574
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Abstract

Experimental allergic encephalomyelitis (EAE) was generated in SJL and B10.PL mice by using the synthetic myelin basic protein peptides. Inflammation in brain and spinal cord preceded clinical signs of disease. Infiltrating lymphocytes were predominantly Lyt1+ (CD5+), L3T4+ (CD4+) T cells, until day 18. After that, F4/80+ monocyte/macrophages outnumbered T cells. Ia+ cells were microglia, macrophages, and endothelial cells, but Ia was not detectable on astrocytes in this EAE model. Ia+ endothelial cells appeared later in the disease than Ia+ microglia and macrophages, suggesting that antigen presentation at the blood-brain barrier is not initially responsible for inflammation. Cells staining for interferon gamma, interleukin 2 (IL-2), and IL-2 receptors were more prominent than IL-4, IL-5, lymphotoxin (LT), and tumor necrosis factor alpha (TNF-alpha), which occurred transiently in the second week and were associated with fewer cells. TNF-alpha and LT were never seen in spinal cord, suggesting that these cytokines are not responsible for initiation of clinical disease. Few or no cells stained for IL-6, IL-1, or transforming growth factor beta. Control animals injected with complete Freund's adjuvant in saline or control antigen demonstrated no inflammatory cell infiltration or cytokine production. Thus, our findings suggest a peptide-induced EAE model in which Th1 T-cell-macrophage interactions result in the disease process.

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Metadata

Authors
Merrill, J. E., Kono, D. H., Clayton, J., Ando, D. G., Hinton, D. R., & Hofman, F. M.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
1992-01-15
Volume
89
Issue
2
Pages
574-578
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.89.2.574
OpenAlex
W1974439206
Cited by
297
References
28
FWCI
13.87
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice. https://app.cochat.ai/papers/10.1073/pnas.89.2.574
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Merrill, J. E., Kono, D. H., Clayton, J., Ando, D. G., Hinton, D. R., & Hofman, F. M. (1992). Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.2.574

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.