The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins.
Open accessAbstract
A yeast genetic system was developed to study how the basic regions of basic-helix-loop-helix (bHLH) proteins distinguish between related consensus bHLH binding sites, with nucleotide sequence CANNTG. The yeast bHLH protein CBF1 binds to the sequence CAC(A/G)TG found in the yeast centromere element CDE1 and in promoter regions of several yeast genes involved in methionine biosynthesis. Using a functional assay to rescue a mutant cbf1 yeast strain from methionine auxotrophy, we determined that the basic region of CBF1 could be replaced by the homologous region of either the vertebrate USF transcription factor or c-Myc, both of which bind CACGTG. The homologous region of the AP4 transcription factor, which recognizes the sequence CAGCTG, could not functionally replace the CBF1 basic region. However, only a single substitution, Met----Arg, in the AP4 basic region of the inactive chimera CBF-AP4 was sufficient to restore CBF1 function. In randomization experiments, only arginine or lysine provided functional substitutions at the AP4 methionine position. The results suggest that this conserved arginine residue in the basic regions of Myc-related bHLH proteins discriminates between CAC(A/G)TG and related sites.
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Cites
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation
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Cited by
Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212
The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior
Grandori, C., Cowley, S. M., James, L. P., & Eisenman, R. N. (2000) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.16.1.653 · Cited by 1,333
AH RECEPTOR SIGNALING PATHWAYS
Schmidt, J. V., & Bradfield, C. A. (1996) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.12.1.55 · Cited by 899
Metabolism of sulfur amino acids in Saccharomyces cerevisiae.
Thomas, D., & Surdin-Kerjan, Y. (1997) · Microbiology and molecular biology reviews : MMBR · doi:10.1128/.61.4.503-532.1997 · Cited by 678
Hemesath, T. J., Steingrímsson, E., McGill, G., Hansen, M. J., Vaught, J., Hodgkinson, C. A., Arnheiter, H., Copeland, N. G., Jenkins, N. A., & Fisher, D. E. (1994) · Genes & Development · doi:10.1101/gad.8.22.2770 · Cited by 673
Metadata
- Authors
- Dang, C. V., Dolde, C., Gillison, M. L., & Kato, G. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-01-15
- Volume
- 89
- Issue
- 2
- Pages
- 599-602
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978089479
- Cited by
- 160
- References
- 3
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Dang, C. V., Dolde, C., Gillison, M. L., & Kato, G. J. (1992). Discrimination between related DNA sites by a single amino acid residue of Myc-related basic-helix-loop-helix proteins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.89.2.599
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