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Cited by 309HIV Research and TreatmentHIV/AIDS drug development and treatmentEvolution and Genetic Dynamics

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation

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Temin, H M·1993·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.90.15.6900PMC PMC47042
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Abstract

Human immunodeficiency virus variation is extensive and is based on numerous mistakes in reverse transcription. All retrovirus replication requires two strand transfers (growing point jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse transcription are the result of this requirement for the two strand transfers needed to form the provirus.

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Crossref · 10.1073/pnas.90.15.6900

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Metadata

Authors
Temin, H. M.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
Temin, H M
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
1993-08
Volume
90
Issue
15
Pages
6900-6903
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.90.15.6900
PMC
PMC47042
OpenAlex
W2087946368
Cited by
309
References
37
Citations by year
2026: 2 · 2025: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 7 · 2016: 6 · 2015: 3 · 2014: 4 · 2013: 7 · 2012: 7
FWCI
6.91
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p30ca007175-36)
  • U.S. Public Health Service (CA-07175)
  • National Cancer Institute (CA-22443, CA-07175, P01CA022443)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords
strand transfer, human immunodeficiency virus, growing points, retroviral replication
MeSH terms
Mutation, Recombination, Genetic, Retroviridae, RNA-Directed DNA Polymerase, RNA, Viral, Templates, Genetic, Genetic Variation, Virus Replication, Sequence Deletion

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