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Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation

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Temin, H M·1993·Proceedings of the National Academy of Sciences

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Abstract

Human immunodeficiency virus variation is extensive and is based on numerous mistakes in reverse transcription. All retrovirus replication requires two strand transfers (growing point jumps) to synthesize the complete provirus. I propose that the numerous mistakes in reverse transcription are the result of this requirement for the two strand transfers needed to form the provirus.

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Authors: Temin, H. M.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Temin, H M
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1993-08
Volume: 90
Issue: 15
Pages: 6900-6903
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.90.15.6900
PMC: PMC47042
OpenAlex: W2087946368
Cited by: 309
References: 37
Citations by year: 2026: 2 · 2025: 3 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 7 · 2016: 6 · 2015: 3 · 2014: 4 · 2013: 7 · 2012: 7
FWCI: 6.91
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5p30ca007175-36)
U.S. Public Health Service (CA-07175)
National Cancer Institute (CA-22443, CA-07175, P01CA022443)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords: strand transfer, human immunodeficiency virus, growing points, retroviral replication
MeSH terms: Mutation, Recombination, Genetic, Retroviridae, RNA-Directed DNA Polymerase, RNA, Viral, Templates, Genetic, Genetic Variation, Virus Replication, Sequence Deletion

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Retrovirus variation and reverse transcription: abnormal strand transfers result in retrovirus genetic variation

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