The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.
Open accessAbstract
Amyloid beta-peptide (A beta) deposition in senile plaques and cerebral vessels is a neuropathological feature of Alzheimer disease (AD). We examined the possibility that commonly observed variability in A beta deposition in late-onset AD might be related to apolipoprotein E genotype (APOE gene; the two most common alleles are 3 and 4), since APOE4 is a susceptibility gene for late-onset AD and apolipoprotein E interacts strongly with A beta in vitro. In an autopsy series of brains of late-onset AD patients, we found a strong association of APOE4 allele with increased vascular and plaque A beta deposits. Late-onset AD patients with one or two APOE4 alleles have a distinct neuropathological phenotype compared with patients homozygous for APOE3.
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Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
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Self-citationThe precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
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Self-citationAssociation of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
Self-citationRestriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.
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Diagnosis of Alzheimer's Disease
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Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
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Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Self-citationAlzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Liu, C.-C., Kanekiyo, T., Xu, H., & Bu, G. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.263 · Cited by 3,459
Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
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The Amyloid-β Pathway in Alzheimer’s Disease
Hampel, H., Hardy, J., Blennow, K., Chen, C., Perry, G., Kim, S. H., Villemagne, V. L., Aisen, P., Vendruscolo, M., Iwatsubo, T., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01249-0 · Cited by 1,952
Metadata
- Authors
- Schmechel, D. E., Saunders, A. M., Strittmatter, W. J., Crain, B. J., Hulette, C. M., Joo, S. H., Pericak-Vance, M. A., Goldgaber, D., & Roses, A. D.
- Affiliations
- Duke Medical Center (US)
- Department of Medicine (Neurology), Duke University Medical Center, Durham, NC 27710.
- ORCID
- Saunders, A M
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1993-10-15
- Volume
- 90
- Issue
- 20
- Pages
- 9649-9653
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC47627
- OpenAlex
- W2001688761
- Cited by
- 1,525
- References
- 37
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 40 · 2023: 26 · 2022: 30 · 2021: 39 · 2020: 26 · 2019: 32 · 2018: 33 · 2017: 35 · 2016: 44 · 2015: 36 · 2014: 46 · 2013: 47 · 2012: 41
- FWCI
- 48.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r35ag007922-07)
- National Institute on Aging (AG05 128, P50AG005128, AG07922)
- National Center for Research Resources (RR-30)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- amyloid-beta, apolipoprotein E, APOE ε4, APOE3, late-onset Alzheimer's disease, cerebral cortex, amyloid plaques, cerebral amyloid angiopathy, vascular amyloid deposits, genetic susceptibility
- MeSH terms
- Aged, Alzheimer Disease, Apolipoproteins E, Cerebral Cortex, Disease Susceptibility, Homozygote, Humans, Prospective Studies, Retrospective Studies, Amyloid beta-Peptides, Cerebral Amyloid Angiopathy, Neurofibrillary Tangles, Neurofilament Proteins
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