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Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.
Open accessAbstract
Vascular endothelial cell growth factor, a mitogen selective for vascular endothelial cells in vitro that promotes angiogenesis in vivo, functions through distinct membrane-spanning tyrosine kinase receptors. The cDNA encoding a soluble truncated form of one such receptor, fms-like tyrosine kinase receptor, has been cloned from a human vascular endothelial cell library. The mRNA coding region distinctive to this cDNA has been confirmed to be present in vascular endothelial cells. Soluble fms-like tyrosine kinase receptor mRNA, generated by alternative splicing of the same pre-mRNA used to produce the full-length membrane-spanning receptor, encodes the six N-terminal immunoglobulin-like extracellular ligand-binding domains but does not encode the last such domain, transmembrane-spanning region, and intracellular tyrosine kinase domains. The recombinant soluble human receptor binds vascular endothelial cell growth factor with high affinity and inhibits its mitogenic activity for vascular endothelial cells; thus this soluble receptor could act as an efficient specific antagonist of vascular endothelial cell growth factor in vivo.
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Metadata
- Authors
- Kendall, R. L., & Thomas, K. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-11-15
- Volume
- 90
- Issue
- 22
- Pages
- 10705-10709
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1986469266
- Cited by
- 1,394
- References
- 2
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- green
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