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The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span

Grunewald, M., Kumar, S., Sharife, H., Volinsky, E., Gileles-Hillel, A., Licht, T., Permyakova, A., Hinden, L., Azar, S., Friedmann, Y., Kupetz, P., Tzuberi, R., Anisimov, A., Alitalo, K., Horwitz, M., Leebhoff, S., Khoma, O. Z., Hlushchuk, R., Djonov, V., Abramovitch, R., Tam, J., Keshet, E.·2021·Science
DOI 10.1126/science.abc8479
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Abstract

More VEGF, more life—and health span: Advanced aging is celebrated but its ill effects, deterioration at the cell, tissue, and organ levels, are not. Grunewald et al . provide evidence for the vascular theory of aging, which reports that age-related decrease of vascular function is a driver of organismal aging at large (see the Perspective by Augustin and Kipnis). Vascular endothelial growth factor (VEGF) signaling insufficiency underlies this vascular insufficiency in aged mice. A modest compensatory increase in circulatory VEGF was sufficient to preserve a young-like vascular homeostasis, alleviate multiple adverse age-related processes, and ameliorate a host of age-associated pathologies in mice. —BAP

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Crossref · 10.1126/science.abc8479

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Metadata

Authors
Grunewald, M., Kumar, S., Sharife, H., Volinsky, E., Gileles-Hillel, A., Licht, T., Permyakova, A., Hinden, L., Azar, S., Friedmann, Y., Kupetz, P., Tzuberi, R., Anisimov, A., Alitalo, K., Horwitz, M., Leebhoff, S., Khoma, O. Z., Hlushchuk, R., Djonov, V., Abramovitch, R., Tam, J., & Keshet, E.
Affiliations
  • Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Obesity and Metabolism Laboratory, Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel.
  • Bio-Imaging Unit, The Alexander Silberman Institute of Life Sciences, The Hebrew University, Jerusalem, Israel.
  • Translational Cancer Biology Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
  • Topographic and Clinical Anatomy, Institute of Anatomy, University of Bern, Bern, Switzerland.
  • Wohl Institute for Translational Medicine and the Goldyne Savad Institute for Gene Therapy, Hadassah Hospital, Jerusalem, Israel.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2021-07-30
Volume
373
Issue
6554
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.abc8479
Cited by
379
References
7
Language
en
Funders
  • Israel Science Foundation (2779/19, 783/20)
  • Novo Nordisk Fonden (NNF16OC0023554)
  • the Britain Israel Research and Academic Exchange partnership (58BX18MMEK)

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