The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.
Open accessAbstract
Natural killer (NK) cells recognize alloantigens on normal cells. One of these alloantigens correlates with homozygosity for a dimorphism of HLA-C at positions 77-80, which is shared by a number of HLA-C alleles. A second allelic alloantigen correlates with homozygosity for the alternative HLA-C dimorphism, which is shared by the remaining HLA-C alleles. Moreover, NK1- and NK2-specific NK cell lines can be generated by mixed leukocyte cultures in which donor and stimulator are homozygous for the alternative dimorphisms at positions 77-80 of HLA-C. In the present work, the role of HLA-C in NK cell-mediated allorecognition was directly investigated by analyzing the effects produced by transfection of several HLA-C alleles on NK sensitivity of class I-deleted mutant cell lines. Transfection of cells with HLA-C alleles encoding Asn-77-Lys-80 (including HLA-Cw4, -Cw5, and -Cw6) inhibited the lysis of the targets by NK1-specific NK cells, whereas HLA-C alleles encoding Ser-77-Asn-80 (including HLA-Cw1, -Cw7, and -Cw13) protected the targets from NK2-specific NK cells. Thus, HLA-C alleles are the dominant inhibitory ligands that protect targets from lysis by these allospecific NK cells.
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Citations
Cites
Molecular structure of human histocompatibility antigens: the HLA‐C series
Snary, D., Barnstable, C. J., Bodmer, W. F., & Crumpton, M. J. (1977) · European Journal of Immunology · doi:10.1002/eji.1830070816 · Cited by 181
Cited by
Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
Ruggeri, L., Capanni, M., Urbani, E., Perruccio, K., Shlomchik, W. D., Tosti, A., Posati, S., Rogaia, D., Frassoni, F., Aversa, F., et al. (2002) · Science · doi:10.1126/science.1068440 · Cited by 3,380
Lanier, L. L. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.359 · Cited by 1,648
MHC class I molecules and kirs in human history, health and survival
Parham, P. (2005) · Nature Reviews Immunology · doi:10.1038/nri1570 · Cited by 1,203
Hiby, S. E., Walker, J. J., O'Shaughnessy, K. M., Redman, C. W. G., Carrington, M., Trowsdale, J., & Moffett, A. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20041214 · Cited by 1,121
Colonna, M., & Samaridis, J. (1995) · Science · doi:10.1126/science.7716543 · Cited by 736
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Metadata
- Authors
- Colonna, M., Borsellino, G., Falco, M., Ferrara, G. B., & Strominger, J. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1993-12-15
- Volume
- 90
- Issue
- 24
- Pages
- 12000-12004
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2088564222
- Cited by
- 460
- References
- 1
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Colonna, M., Borsellino, G., Falco, M., Ferrara, G. B., & Strominger, J. L. (1993). HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.90.24.12000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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