The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Sorting single molecules: application to diagnostics and evolutionary biotechnology.
Open accessAbstract
A method is described that provides for detection and identification of single molecules in solution. The method is based on fluorescence correlation spectroscopy, which records spatio-temporal correlations among fluctuating light signals, coupled with devices for trapping single molecules in an electric field. This technique is applied to studies of molecular evolution, where it allows fast screening of large mutant spectra in which targets are labeled by specific fluorescent ligands. The method expands the horizon in molecular diagnostics by making it possible to monitor concentrations down to (less than) 10(-15) M without any need for amplification.
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Cites
Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide
Nielsen, P. E., Egholm, M., Berg, R. H., & Buchardt, O. (1991) · Science · doi:10.1126/science.1962210 · Cited by 3,332
Cited by
Principles of two-photon excitation microscopy and its applications to neuroscience
Svoboda, K., & Yasuda, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.019 · Cited by 1,027
Probing Individual Molecules with Confocal Fluorescence Microscopy
Nie, S., Chiu, D. T., & Zare, R. N. (1994) · Science · doi:10.1126/science.7973650 · Cited by 549
Probing Lipid Mobility of Raft-exhibiting Model Membranes by Fluorescence Correlation Spectroscopy
Kahya, N., Scherfeld, D., Bacia, K., Poolman, B., & Schwille, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302969200 · Cited by 499
Berland, K. M., So, P. T., & Gratton, E. (1995) · Biophysical Journal · doi:10.1016/s0006-3495(95)80230-4 · Cited by 490
Fluorescence Correlation Spectroscopy: Past, Present, Future
Elson, E. L. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2011.11.012 · Cited by 438
Metadata
- Authors
- Eigen, M., & Rigler, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1994-06-21
- Volume
- 91
- Issue
- 13
- Pages
- 5740-5747
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2026277335
- Cited by
- 956
- References
- 1
- FWCI
- 24.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Eigen, M., & Rigler, R. (1994). Sorting single molecules: application to diagnostics and evolutionary biotechnology. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.91.13.5740
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
