The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis.
Open accessAbstract
PR-39, a proline/arginine-rich peptide antibiotic, has been purified from pig intestine and later shown to originate in the bone marrow. Intending to isolate a clone for a human counterpart to PR-39, we synthesized a PCR probe derived from the PR-39 gene. However, when this probe was used to screen a human bone marrow cDNA library, eight clones were obtained with information for another putative human peptide antibiotic, designated FALL-39 after the first four residues. FALL-39 is a 39-residue peptide lacking cysteine and tryptophan. All human peptide antibiotics previously isolated (or predicted) belong to the defensin family and contain three disulfide bridges. The clone for prepro-FALL-39 encodes a cathelin-like precursor protein with 170 amino acid residues. We have postulated a dibasic processing site for the mature FALL-39 and chemically synthesized the putative peptide. In basal medium E, synthetic FALL-39 was highly active against Escherichia coli and Bacillus megaterium. Residues 13-34 in FALL-39 can be predicted to form a perfect amphiphatic helix, and CD spectra showed that medium E induced 30% helix formation in FALL-39. RNA blot analyses disclosed that the gene for FALL-39 is expressed mainly in human bone marrow and testis.
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Cites
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Cited by
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Metadata
- Authors
- Agerberth, B., Gunne, H., Odeberg, J., Kogner, P., Boman, H. G., & Gudmundsson, G. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-01-03
- Volume
- 92
- Issue
- 1
- Pages
- 195-199
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2050242176
- Cited by
- 503
- References
- 28
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Agerberth, B., Gunne, H., Odeberg, J., Kogner, P., Boman, H. G., & Gudmundsson, G. H. (1995). FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.1.195
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