The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
The causes and prevention of cancer.
Open accessAbstract
Epidemiological evidence indicates that avoidance of smoking, increased consumption of fruits and vegetables, and control of infections will have a major effect on reducing rates of cancer. Other factors include avoidance of intense sun exposure, increases in physical activity, and reduction of alcohol consumption and possibly red meat. A substantial reduction in breast cancer is likely to require modification of sex hormone levels, and development of practical methods for doing so is a high research priority. Resolution of the potential protective roles of specific antioxidants and other constituents of fruits and vegetables deserves major attention. Mechanistic studies of carcinogenesis indicate an important role of endogenous oxidative damage to DNA that is balanced by elaborate defense and repair processes. Also key is the rate of cell division, which is influenced by hormones, growth, cytotoxicity, and inflammation, as this determines the probability of converting DNA lesions to mutations. These mechanisms may underlie many epidemiologic observations.
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Cites
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Vegetables, fruit, and cancer. I. Epidemiology
Steinmetz, K. A., & Potter, J. D. (1991) · Cancer Causes and Control · doi:10.1007/bf00051672 · Cited by 1,118
THE DECLINE IN GASTRIC CANCER: EPIDEMIOLOGY OF AN UNPLANNED TRIUMPH
HOWSON, C. P., HIYAMA, T., & WYNDER, E. L. (1986) · Epidemiologic Reviews · doi:10.1093/oxfordjournals.epirev.a036288 · Cited by 829
Vegetables, fruit, and cancer. II. Mechanisms
Steinmetz, K. A., & Potter, J. D. (1991) · Cancer Causes and Control · doi:10.1007/bf00054304 · Cited by 804
A Clinical Trial of Beta Carotene to Prevent Basal-Cell and Squamous-Cell Cancers of the Skin
Greenberg, E. R., Baron, J. A., Stukel, T. A., Stevens, M. M., Mandel, J. S., Spencer, S. K., Elias, P. M., Lowe, N., Nierenberg, D. W., Bayrd, G., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199009203231204 · Cited by 482
Effects of smoking and vitamin E on blood antioxidant status
Duthie, G., Arthur, Jr., & James, W. P. T. (1991) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/53.4.1061s · Cited by 162
Interspecies extrapolation in carcinogenesis: prediction between rats and mice.
Gold, L. S., Bernstein, L., Magaw, R., & Slone, T. H. (1989) · Environmental Health Perspectives · doi:10.1289/ehp.8981211 · Cited by 131
Self-citation
Cited by
The Chemistry behind Antioxidant Capacity Assays
Huang, D., Ou, B., & Prior, R. L. (2005) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf030723c · Cited by 6,162
The Free Radical Theory of Aging Matures
BECKMAN, K. B., & AMES, B. N. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.2.547 · Cited by 3,879
Self-citationTobacco Smoke Carcinogens and Lung Cancer
Hecht, S. S. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.14.1194 · Cited by 1,976
Kushi, L. H., Byers, T., Doyle, C., Bandera, E. V., McCullough, M., Gansler, T., Andrews, K. S., Thun, M. J., & The American Cancer Society 2006 Nutrition and Physical Activity Guidelines Advisory Committee (2006) · CA A Cancer Journal for Clinicians · doi:10.3322/canjclin.56.5.254 · Cited by 1,901
Hussain, S. P., Hofseth, L. J., & Harris, C. C. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1046 · Cited by 1,690
Metadata
- Authors
- Ames, B. N., Gold, L. S., & Willett, W. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1995-06-06
- Volume
- 92
- Issue
- 12
- Pages
- 5258-5265
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2023518603
- Cited by
- 1,319
- References
- 7
- FWCI
- 25.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Ames, B. N., Gold, L. S., & Willett, W. C. (1995). The causes and prevention of cancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.92.12.5258
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
